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Serpinb10 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 [ Mus musculus (house mouse) ]

Gene ID: 241197, updated on 5-Mar-2024

Summary

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Official Symbol
Serpinb10provided by MGI
Official Full Name
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10provided by MGI
Primary source
MGI:MGI:2138648
See related
Ensembl:ENSMUSG00000092572 AllianceGenome:MGI:2138648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830131G07; Serpinb10-ps
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be active in extracellular space. Is expressed in several structures, including esophagus; liver lobe; oral epithelium; and skin. Orthologous to human SERPINB10 (serpin family B member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
1 E2.1; 1 50.34 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (107456724..107488469)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (107528994..107560742)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 7 Neighboring gene STARR-positive B cell enhancer mm9_chr1:109342973-109343273 Neighboring gene STARR-positive B cell enhancer mm9_chr1:109343789-109344089 Neighboring gene predicted gene, 24553 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 2 Neighboring gene STARR-seq mESC enhancer starr_01868 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 8 Neighboring gene STARR-seq mESC enhancer starr_01869 Neighboring gene STARR-seq mESC enhancer starr_01870 Neighboring gene predicted gene 15389

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells. Mo Y, et al. Respir Res, 2021 Jun 14. PMID 34126986, Free PMC Article
  2. Epithelial SERPINB10, a novel marker of airway eosinophilia in asthma, contributes to allergic airway inflammation. Mo Y, et al. Am J Physiol Lung Cell Mol Physiol, 2019 Jan 1. PMID 30382768
  3. Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus. Askew DJ, et al. Genomics, 2004 Jul. PMID 15203215
  4. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells.
    Title: SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells.
  2. Epithelial SERPINB10 contributes to allergic airway eosinophilic inflammation, at least in part, by regulating the expression of periostin and CCL26.
    Title: Epithelial SERPINB10, a novel marker of airway eosinophilia in asthma, contributes to allergic airway inflammation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serpin B10
Names
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10, pseudogene
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160307.1 → NP_001153779.1  serpin B10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC148982, AK036537, AK052580
    Consensus CDS
    CCDS48338.1
    UniProtKB/Swiss-Prot
    Q8K1K6
    Conserved Domains (1) summary
    cl00137
    Location:1 → 320
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

  2. NM_198028.3 → NP_932145.3  serpin B10 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC148982, AK036537, AK052580
    UniProtKB/Swiss-Prot
    Q8K1K6
    Related
    ENSMUSP00000141672.2, ENSMUST00000194951.3
    Conserved Domains (1) summary
    cl00137
    Location:1 → 357
    SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    107456724..107488469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529597.4 → XP_006529660.1  serpin B10 isoform X1

    Conserved Domains (1) summary
    cl38926
    Location:1 → 277
    serpin; SERine Proteinase INhibitors (serpin) family

  2. XM_006529598.4 → XP_006529661.1  serpin B10 isoform X2

    Conserved Domains (1) summary
    cl38926
    Location:1 → 240
    serpin; SERine Proteinase INhibitors (serpin) family

  3. XM_006529599.1 → XP_006529662.1  serpin B10 isoform X3

    Conserved Domains (1) summary
    cl38926
    Location:1 → 268
    serpin; SERine Proteinase INhibitors (serpin) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K1K6.1 GenPept UniProtKB/Swiss-Prot:Q8K1K6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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