U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nelfa negative elongation factor complex member A, Whsc2 [ Mus musculus (house mouse) ]

Gene ID: 24116, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Nelfaprovided by MGI
Official Full Name
negative elongation factor complex member A, Whsc2provided by MGI
Primary source
MGI:MGI:1346098
See related
Ensembl:ENSMUSG00000029111 AllianceGenome:MGI:1346098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Whsc2; Whsc2h
Summary
Enables chromatin binding activity. Acts upstream of or within negative regulation of transcription elongation from RNA polymerase II promoter. Located in nucleus. Is expressed in several structures, including early embryo; genitourinary system; liver; spleen; and trunk somite. Orthologous to human NELFA (negative elongation factor complex member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 34.0), limb E14.5 (RPKM 29.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5 B2; 5 17.83 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34055263..34093615, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (33897916..33936301, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12830 Neighboring gene leucine zipper-EF-hand containing transmembrane protein 1 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6319 Neighboring gene ATP synthase subunit g, mitochondrial pseudogene Neighboring gene nuclear receptor binding SET domain protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34194226-34194436 Neighboring gene STARR-seq mESC enhancer starr_12832 Neighboring gene microRNA 7024 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34279052-34279239 Neighboring gene STARR-seq mESC enhancer starr_12833 Neighboring gene STARR-seq mESC enhancer starr_12834 Neighboring gene predicted gene, 30802 Neighboring gene NELL2 interacting cell ontogeny regulator 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Acute NelfA knockdown restricts compensatory gene expression and precipitates ventricular dysfunction during cardiac hypertrophy. Alikunju S, et al. J Mol Cell Cardiol, 2020 May. PMID 32278832, Free PMC Article
  2. Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells. Hu Z, et al. Nat Cell Biol, 2020 Feb. PMID 31932739
  3. MicroRNA-133 controls cardiac hypertrophy. Carè A, et al. Nat Med, 2007 May. PMID 17468766
  4. Comparative analysis of a novel gene from the Wolf-Hirschhorn/Pitt-Rogers-Danks syndrome critical region. Wright TJ, et al. Genomics, 1999 Jul 15. PMID 10409432
  5. A transcript map of the newly defined 165 kb Wolf-Hirschhorn syndrome critical region. Wright TJ, et al. Hum Mol Genet, 1997 Feb. PMID 9063753

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NELFA and BCL2 induce the 2C-like state in mouse embryonic stem cells in a chemically defined medium.
    Title: NELFA and BCL2 induce the 2C-like state in mouse embryonic stem cells in a chemically defined medium.
  2. Acute NelfA knockdown restricts compensatory gene expression and precipitates ventricular dysfunction during cardiac hypertrophy.
    Title: Acute NelfA knockdown restricts compensatory gene expression and precipitates ventricular dysfunction during cardiac hypertrophy.
  3. Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells through Dux.
    Title: Maternal factor NELFA drives a 2C-like state in mouse embryonic stem cells.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (4) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription elongation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription elongation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein modification process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of NELF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NELF complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
negative elongation factor A
Names
Wolf-Hirschhorn syndrome candidate 2 homolog

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415983.1 → NP_001402912.1  negative elongation factor A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC163329

  2. NM_001415984.1 → NP_001402913.1  negative elongation factor A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC163329

  3. NM_001415985.1 → NP_001402914.1  negative elongation factor A isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163329

  4. NM_001415986.1 → NP_001402915.1  negative elongation factor A isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC163329

  5. NM_001415987.1 → NP_001402916.1  negative elongation factor A isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC163329

  6. NM_001415988.1 → NP_001402917.1  negative elongation factor A isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC163329

  7. NM_011914.4 → NP_036044.1  negative elongation factor A isoform 1

    See identical proteins and their annotated locations for NP_036044.1

    Status: VALIDATED

    Source sequence(s)
    AC163329
    Consensus CDS
    CCDS19208.1
    UniProtKB/Swiss-Prot
    Q8BG30, Q8BVE4, Q8VEI7, Q9CSJ9, Q9Z1V9
    UniProtKB/TrEMBL
    Q3UK41
    Related
    ENSMUSP00000030993.7, ENSMUST00000030993.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    34055263..34093615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG30.1 GenPept UniProtKB/Swiss-Prot:Q8BG30

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous