Usp18 ubiquitin specific peptidase 18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp18provided by MGI
Official Full Name: ubiquitin specific peptidase 18provided by MGI
Primary source: MGI:MGI:1344364
See related: Ensembl:ENSMUSG00000030107 AllianceGenome:MGI:1344364
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: UBP43; Ubp15; 1110058H21Rik
Summary: Enables ISG15-specific protease activity. Acts upstream of or within response to bacterium and response to stilbenoid. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol and nucleus. Is expressed in axial skeleton; lung; and mandible. Orthologous to several human genes including USP18 (ubiquitin specific peptidase 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver E18 (RPKM 13.2), thymus adult (RPKM 10.2) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 F1; 6 57.17 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (121222865..121247876)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (121245906..121270917)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3zeta protein and represses lung cancer metastasis.
Title: Loss of ubiquitin-specific peptidase 18 destabilizes 14-3-3ζ protein and represses lung cancer metastasis.
Deubiquitinase USP18 regulates reactive astrogliosis by stabilizing SOX9.
Title: Deubiquitinase USP18 regulates reactive astrogliosis by stabilizing SOX9.
Ubiquitin-specific peptidase 18 negatively regulates and inhibits lipopolysaccharide-induced sepsis by targeting transforming growth factor-beta-activated kinase 1 activity.
Title: Ubiquitin-specific peptidase 18 negatively regulates and inhibits lipopolysaccharide-induced sepsis by targeting transforming growth factor-β-activated kinase 1 activity.
The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth.
Title: The Ubiquitin-Specific Peptidase USP18 Promotes Lipolysis, Fatty Acid Oxidation, and Lung Cancer Growth.
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
Title: USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS.
USP18 Overexpression Protects against Focal Cerebral Ischemia Injury in Mice by Suppressing Microglial Activation.
Title: USP18 Overexpression Protects against Focal Cerebral Ischemia Injury in Mice by Suppressing Microglial Activation.
Deletion of Usp18 in mouse dendritic cells was sufficient to enhance host control of infections with two strains of Gram-positive bacteria. Normal induction of USP18 after infection impaired antibacterial responses mediated by tumor necrosis factor. These findings spotlight USP18 as a new potential target for therapeutics aimed at improving control of serious bacterial infections.
Title: The probacterial effect of type I interferon signaling requires its own negative regulator USP18.
Usp18 protects the cells from oxidative stress-induced apoptosis which may be through the regulation of p53 and caspase 3.
Title: Deubiquitinase Usp18 prevents cellular apoptosis from oxidative stress in liver cells.
associates with and deubiquitinates TAK1 to protect against hepatic steatosis, insulin resistance, and the inflammatory response
Title: USP18 protects against hepatic steatosis and insulin resistance through its deubiquitinating activity.
this study identifies the osteopenia phenotype of mice lacking Usp18, which is known as a negative regulator of type I IFN signaling
Title: Elevated Response to Type I IFN Enhances RANKL-Mediated Osteoclastogenesis in Usp18-Knockout Mice.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ISG15-specific peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ISG15-specific peptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein deubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubl carboxyl-terminal hydrolase 18

Names: 43 kDa ISG15-specific protease; ISG15-specific-processing protease; ubiquitin specific protease 15; ubiquitin specific protease 18; ubl thioesterase 18; ubl thiolesterase 18

NP_036039.2

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011909.2 → NP_036039.2 ubl carboxyl-terminal hydrolase 18

See identical proteins and their annotated locations for NP_036039.2

Status: VALIDATED

Source sequence(s)

AA286391, AK151260, AK153312

Consensus CDS

CCDS20489.1

UniProtKB/Swiss-Prot

Q3U7P3, Q9WTV6

UniProtKB/TrEMBL

B2RRS6, Q3UE35, Q4FK24

Related

ENSMUSP00000032198.10, ENSMUST00000032198.11

Conserved Domains (2) summary

cd02257
Location:53 → 363

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

pfam00443
Location:51 → 363

UCH; Ubiquitin carboxyl-terminal hydrolase