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Plekhm3 pleckstrin homology domain containing, family M, member 3 [ Mus musculus (house mouse) ]

Gene ID: 241075, updated on 5-Mar-2024

Summary

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Official Symbol
Plekhm3provided by MGI
Official Full Name
pleckstrin homology domain containing, family M, member 3provided by MGI
Primary source
MGI:MGI:2443627
See related
Ensembl:ENSMUSG00000051344 AllianceGenome:MGI:2443627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DAPR; Plekhm1l; 9430067K14Rik; A230102O09Rik
Summary
Predicted to enable metal ion binding activity. Involved in myoblast differentiation. Located in Golgi apparatus and plasma membrane. Orthologous to human PLEKHM3 (pleckstrin homology domain containing M3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 4.4), cerebellum adult (RPKM 3.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C2; 1 32.76 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (64828279..64995983, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (64789120..64956824, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E983 Neighboring gene STARR-positive B cell enhancer ABC_E9466 Neighboring gene cyclin Y-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E11072 Neighboring gene STARR-seq mESC enhancer starr_01166 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:64784525-64784634 Neighboring gene frizzled class receptor 5 Neighboring gene leucine rich repeat containing 15 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:64912785-64913085 Neighboring gene predicted gene, 51628 Neighboring gene STARR-positive B cell enhancer ABC_E5764 Neighboring gene ribosomal protein L31, pseudogene 24 Neighboring gene predicted gene, 51627 Neighboring gene ribosomal protein L10A, pseudogene 1 Neighboring gene predicted gene, 24788

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction. Zhang X, et al. Signal Transduct Target Ther, 2021 Feb 18. PMID 33597502, Free PMC Article
  2. Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling. Virtanen C, et al. J Biol Chem, 2009 Jan 16. PMID 19028694
  3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction.
    Title: The double face of miR-320: cardiomyocytes-derived miR-320 deteriorated while fibroblasts-derived miR-320 protected against heart failure induced by transverse aortic constriction.
  2. DAPR is a novel gene that binds to PKB/AKT and is a critical component for the differentiation of skeletal muscle myoblast cells into myotubes.
    Title: Identification and characterization of a novel gene, dapr, involved in skeletal muscle differentiation and protein kinase B signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in myoblast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
pleckstrin homology domain-containing family M member 3
Names
PH domain-containing family M member 3
differentiation associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039493.1 → NP_001034582.1  pleckstrin homology domain-containing family M member 3

    See identical proteins and their annotated locations for NP_001034582.1

    Status: VALIDATED

    Source sequence(s)
    AC101915, BC063098
    Consensus CDS
    CCDS15009.1
    UniProtKB/Swiss-Prot
    Q3T9Y1, Q8BM47
    Related
    ENSMUSP00000095320.2, ENSMUST00000097713.2
    Conserved Domains (3) summary
    cd14674
    Location:215 → 304
    PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
    pfam13901
    Location:530 → 727
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl17171
    Location:364 → 451
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    64828279..64995983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495983.5 → XP_006496046.1  pleckstrin homology domain-containing family M member 3 isoform X2

    See identical proteins and their annotated locations for XP_006496046.1

    Conserved Domains (2) summary
    pfam13901
    Location:255 → 452
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl17171
    Location:89 → 176
    PH-like; Pleckstrin homology-like domain

  2. XM_006495982.3 → XP_006496045.1  pleckstrin homology domain-containing family M member 3 isoform X1

    See identical proteins and their annotated locations for XP_006496045.1

    UniProtKB/Swiss-Prot
    Q3T9Y1, Q8BM47
    Conserved Domains (3) summary
    cd14674
    Location:215 → 304
    PH_PLEKHM3_1; Pleckstrin homology domain-containing family M member 3 Pleckstrin homology domain 1
    pfam13901
    Location:530 → 727
    zf-RING_9; Putative zinc-RING and/or ribbon
    cl17171
    Location:364 → 451
    PH-like; Pleckstrin homology-like domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_175509.3: Suppressed sequence

    Description
    NM_175509.3: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BM47.1 GenPept UniProtKB/Swiss-Prot:Q8BM47

Gene LinkOut

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