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Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b [ Mus musculus (house mouse) ]

Gene ID: 24099, updated on 11-Apr-2024

Summary

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Official Symbol
Tnfsf13bprovided by MGI
Official Full Name
tumor necrosis factor (ligand) superfamily, member 13bprovided by MGI
Primary source
MGI:MGI:1344376
See related
Ensembl:ENSMUSG00000031497 AllianceGenome:MGI:1344376
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BAFF; BLyS; TALL1; THANK; zTNF4; TALL-1; Tnlg7a; TNFSF20; D8Ertd387e
Summary
Predicted to enable receptor ligand activity. Involved in B cell differentiation and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within B cell homeostasis; positive regulation of germinal center formation; and positive regulation of lymphocyte activation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in extracellular space. Is expressed in genitourinary system. Used to study IgA glomerulonephritis and Sjogren's syndrome. Orthologous to human TNFSF13B (TNF superfamily member 13b). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 5.5), bladder adult (RPKM 3.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Tnfsf13b in Genome Data Viewer
Location:
8 A1.1; 8 4.55 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (10056637..10086000)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (10006229..10036000)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8225 Neighboring gene STARR-positive B cell enhancer ABC_E10489 Neighboring gene abhydrolase domain containing 13 Neighboring gene ligase IV, DNA, ATP-dependent Neighboring gene predicted gene 44788 Neighboring gene STARR-seq mESC enhancer starr_20696 Neighboring gene myosin XVI Neighboring gene predicted gene, 51560

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. B cell-activating factor (BAFF) from dendritic cells, monocytes and neutrophils is required for B cell maturation and autoantibody production in SLE-like autoimmune disease. Giordano D, et al. Front Immunol, 2023. PMID 36923413, Free PMC Article
  2. Role of B Cell-Activating Factor in Fibrosis Progression in a Murine Model of Non-Alcoholic Steatohepatitis. Kanemitsu-Okada K, et al. Int J Mol Sci, 2023 Jan 28. PMID 36768854, Free PMC Article
  3. B cell activating factor (BAFF) from neutrophils and dendritic cells is required for protective B cell responses against Salmonella typhimurium infection. Kuley R, et al. PLoS One, 2021. PMID 34705890, Free PMC Article
  4. Long-term exposure to monoclonal anti-TNF is associated with an increased risk of lymphoma in BAFF-transgenic mice. Nocturne G, et al. Clin Exp Immunol, 2021 Aug. PMID 33864242, Free PMC Article
  5. BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation. Jia W, et al. Blood, 2021 May 6. PMID 33534893, Free PMC Article

See all (224) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Blockade of BLyS inhibits B-cell responses and antibody production for the prevention of chronic transplant rejection.
    Title: Blockade of BLyS inhibits B-cell responses and antibody production for the prevention of chronic transplant rejection.
  2. An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia.
    Title: An unappreciated cell survival-independent role for BAFF initiating chronic lymphocytic leukemia.
  3. Transcriptome analysis of renal ischemia/reperfusion (I/R) injury in BAFF and BAFF-R deficient mice.
    Title: Transcriptome analysis of renal ischemia/reperfusion (I/R) injury in BAFF and BAFF-R deficient mice.
  4. BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth.
    Title: BAFF and APRIL counterregulate susceptibility to inflammation-induced preterm birth.
  5. B cell-activating factor (BAFF) from dendritic cells, monocytes and neutrophils is required for B cell maturation and autoantibody production in SLE-like autoimmune disease.
    Title: B cell-activating factor (BAFF) from dendritic cells, monocytes and neutrophils is required for B cell maturation and autoantibody production in SLE-like autoimmune disease.
  6. B Cell and T Cell Dissimilarities in BAFF-Deficient versus BR3-Deficient C57BL/6 Mice.
    Title: B Cell and T Cell Dissimilarities in BAFF-Deficient versus BR3-Deficient C57BL/6 Mice.
  7. BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment.
    Title: BAFF Attenuates Immunosuppressive Monocytes in the Melanoma Tumor Microenvironment.
  8. Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves' disease.
    Title: Possible interplay between estrogen and the BAFF may modify thyroid activity in Graves' disease.
  9. DYRK1a mediates BAFF-induced noncanonical NF-kappaB activation to promote autoimmunity and B-cell leukemogenesis.
    Title: DYRK1a mediates BAFF-induced noncanonical NF-κB activation to promote autoimmunity and B-cell leukemogenesis.
  10. BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.
    Title: BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation.
Submit: New GeneRIF Correction See all GeneRIFs (171)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124060, MGC124061

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables receptor ligand activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within B cell costimulation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of B cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within T cell costimulation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of germinal center formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within immunoglobulin production IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within immunoglobulin production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of B cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of B cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of germinal center formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skin development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transitional one stage B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tumor necrosis factor ligand superfamily member 13B
Names
b cell-activating factor
tumor necrosis factor ligand 7a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347309.2 → NP_001334238.1  tumor necrosis factor ligand superfamily member 13B isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC138397
    Consensus CDS
    CCDS85498.1
    UniProtKB/TrEMBL
    Q3U2H2
    Related
    ENSMUSP00000033892.9, ENSMUST00000033892.9

  2. NM_001425009.1 → NP_001411938.1  tumor necrosis factor ligand superfamily member 13B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC138397
    UniProtKB/TrEMBL
    A0A0U5J6R6

  3. NM_033622.3 → NP_296371.1  tumor necrosis factor ligand superfamily member 13B isoform 1

    See identical proteins and their annotated locations for NP_296371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC138397
    Consensus CDS
    CCDS22094.1
    UniProtKB/Swiss-Prot
    Q7TQ58, Q9WU72
    UniProtKB/TrEMBL
    Q3KP92, Q3U2H2
    Related
    ENSMUSP00000146694.2, ENSMUST00000207792.3
    Conserved Domains (2) summary
    cd00184
    Location:170 → 306
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...
    cl11564
    Location:81 → 155
    GcrA; GcrA cell cycle regulator

RNA

  1. NR_189032.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC138397

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    10056637..10086000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WU72.1 GenPept UniProtKB/Swiss-Prot:Q9WU72

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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