Tlr2 toll-like receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlr2provided by MGI
Official Full Name: toll-like receptor 2provided by MGI
Primary source: MGI:MGI:1346060
See related: Ensembl:ENSMUSG00000027995 AllianceGenome:MGI:1346060
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly105
Summary: Enables lipoteichoic acid binding activity and peptide binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of cytokine production; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including pattern recognition receptor signaling pathway; regulation of cytokine production; and response to bacterium. Located in external side of plasma membrane. Part of Toll-like receptor 2-Toll-like receptor 6 protein complex. Is expressed in several structures, including brain; early embryo; genitourinary system; gut; and immune system. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 3.8), bladder adult (RPKM 3.5) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 E3; 3 37.4 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (83743579..83749045, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (83836272..83841824, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
Title: p53 suppresses the inflammatory response following respiratory syncytial virus infection by inhibiting TLR2.
Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar Macrophages Via Regulating TLR2 Expression.
Title: Age-Associated KLF9 Enhances the Inflammatory Response of Alveolar Macrophages Via Regulating TLR2 Expression.
DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.
Title: DDX5 inhibits inflammation by modulating m6A levels of TLR2/4 transcripts during bacterial infection.
Toll-like receptor 2 deficiency ameliorates obesity-induced cardiomyopathy via inhibiting NF-kappaB signaling pathway.
Title: Toll-like receptor 2 deficiency ameliorates obesity-induced cardiomyopathy via inhibiting NF-κB signaling pathway.
Proinflammatory signaling mechanism of endocan in macrophages: Involvement of TLR2 mediated MAPK-NFkB pathways.
Title: Proinflammatory signaling mechanism of endocan in macrophages: Involvement of TLR2 mediated MAPK-NFkB pathways.
Impact of surface receptors TLR2, CR3, and FcgammaRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages.
Title: Impact of surface receptors TLR2, CR3, and FcγRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages.
TLR2 regulates Moraxella catarrhalis adhesion to and invasion into alveolar epithelial cells and mediates inflammatory responses.
Title: TLR2 regulates Moraxella catarrhalis adhesion to and invasion into alveolar epithelial cells and mediates inflammatory responses.
TLR2 mediates renal apoptosis in neonatal mice subjected experimentally to obstructive nephropathy.
Title: TLR2 mediates renal apoptosis in neonatal mice subjected experimentally to obstructive nephropathy.
TLR2 mediates autophagy through ERK signaling pathway in Chlamydia psittaci CPSIT_p7 protein-stimulated RAW264.7 cells.
Title: TLR2 mediates autophagy through ERK signaling pathway in Chlamydia psittaci CPSIT_p7 protein-stimulated RAW264.7 cells.
C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity.
Title: C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity.

Submit: New GeneRIF Correction See all GeneRIFs (1102)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (10) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC98510P1 (e-PCR)
- UniSTS:273671

PMC133006P1 (e-PCR)
- UniSTS:270621

Tlr2 (e-PCR), detects polymorphism
- UniSTS:495946

RH144365 (e-PCR)
- UniSTS:233610

PMC213490P1 (e-PCR)
- UniSTS:272040

NoName (e-PCR)
- UniSTS:234715

PMC128073P1 (e-PCR)
- UniSTS:270563

PMC128159P2 (e-PCR)
- UniSTS:270573

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Toll-like receptor binding	ISO Inferred from Sequence Orthology more info
enables amyloid-beta binding	IDA Inferred from Direct Assay more info	PubMed
enables amyloid-beta binding	ISO Inferred from Sequence Orthology more info
enables diacyl lipopeptide binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipopeptide binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables lipoteichoic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables pattern recognition receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables triacyl lipopeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables triacyl lipopeptide binding	IDA Inferred from Direct Assay more info	PubMed
enables triacyl lipopeptide binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in I-kappaB phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within MyD88-dependent toll-like receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell surface pattern recognition receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to bacterial lipopeptide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to bacterial lipopeptide	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cellular response to diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to lipoteichoic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lipoteichoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to peptidoglycan	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to triacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of diacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within detection of triacyl bacterial lipopeptide	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of interleukin-17 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukotriene metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglia development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of actin filament polymerization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of interleukin-17 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of synapse assembly	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nitric oxide metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cellular response to macrophage colony-stimulating factor stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-18 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of matrix metallopeptidase secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of nitric oxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of nitric-oxide synthase biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of xenophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of dendritic cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in response to bacterial lipoprotein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to fatty acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to molecule of fungal origin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to peptidoglycan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor TLR6:TLR2 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of xenophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of Toll-like receptor 1-Toll-like receptor 2 protein complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of Toll-like receptor 2-Toll-like receptor 6 protein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of Toll-like receptor 2-Toll-like receptor 6 protein complex	ISO Inferred from Sequence Orthology more info
located_in cell body	ISO Inferred from Sequence Orthology more info
located_in cell projection	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: toll-like receptor 2

NP_036035.3

EC 3.2.2.6

XP_006501523.1

EC 3.2.2.6

XP_030108471.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011905.3 → NP_036035.3 toll-like receptor 2 precursor

See identical proteins and their annotated locations for NP_036035.3

Status: VALIDATED

Source sequence(s)

AK005043, BP771904, BY743020

Consensus CDS

CCDS17435.1

UniProtKB/Swiss-Prot

Q3U400, Q9DBC4, Q9QUN7

UniProtKB/TrEMBL

G3X8Y8

Related

ENSMUSP00000029623.10, ENSMUST00000029623.11

Conserved Domains (7) summary

smart00255
Location:640 → 784

TIR; Toll - interleukin 1 - resistance

cd00116
Location:55 → 151

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:55 → 77

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:176 → 202

LRR_RI; leucine-rich repeat [structural motif]

pfam12799
Location:459 → 494

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:77 → 135

LRR_8; Leucine rich repeat

cl15307
Location:533 → 586

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

83743579..83749045 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501460.4 → XP_006501523.1 toll-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

Q3U400, Q9DBC4, Q9QUN7

Conserved Domains (7) summary

PRK15370
Location:350 → 568

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00255
Location:650 → 794

TIR; Toll - interleukin 1 - resistance

sd00031
Location:65 → 87

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:186 → 212

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:87 → 145

LRR_8; Leucine rich repeat

NF033189
Location:58 → 259

internalin_A; class 1 internalin InlA

cl15307
Location:543 → 596

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
XM_030252611.2 → XP_030108471.1 toll-like receptor 2 isoform X1

UniProtKB/Swiss-Prot

Q3U400, Q9DBC4, Q9QUN7

Conserved Domains (7) summary

PRK15370
Location:350 → 568

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

smart00255
Location:650 → 794

TIR; Toll - interleukin 1 - resistance

sd00031
Location:65 → 87

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:186 → 212

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:87 → 145

LRR_8; Leucine rich repeat

NF033189
Location:58 → 259

internalin_A; class 1 internalin InlA

cl15307
Location:543 → 596

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain