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Ntmt2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 [ Mus musculus (house mouse) ]

Gene ID: 240879, updated on 11-Apr-2024

Summary

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Official Symbol
Ntmt2provided by MGI
Official Full Name
N-terminal Xaa-Pro-Lys N-methyltransferase 2provided by MGI
Primary source
MGI:MGI:2685053
See related
Ensembl:ENSMUSG00000040113 AllianceGenome:MGI:2685053
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm207; NTM1B; Mettl11b
Summary
Predicted to enable N-terminal protein N-methyltransferase activity. Predicted to be involved in N-terminal protein amino acid methylation. Predicted to act upstream of or within methylation. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human NTMT2 (N-terminal Xaa-Pro-Lys N-methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
1 H2.1; 1 71.0 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (163529415..163552801, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (163702993..163725232, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02854 Neighboring gene predicted gene, 53641 Neighboring gene predicted gene, 57570 Neighboring gene STARR-seq mESC enhancer starr_02855 Neighboring gene STARR-seq mESC enhancer starr_02856 Neighboring gene STARR-seq mESC enhancer starr_02857 Neighboring gene GC-rich promoter binding protein 1-like 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:165709472-165709665 Neighboring gene predicted gene, 51663 Neighboring gene kinesin-associated protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-terminal protein N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-terminal protein N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal protein amino acid methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-terminal protein amino acid methylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-terminal Xaa-Pro-Lys N-methyltransferase 2
Names
X-Pro-Lys N-terminal protein methyltransferase 1B
alpha N-terminal protein methyltransferase 1B
methyltransferase like 11B
methyltransferase-like protein 11B
NP_001137428.1
XP_036020749.1
XP_036020757.1
XP_036020760.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143956.1 → NP_001137428.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2

    See identical proteins and their annotated locations for NP_001137428.1

    Status: PROVISIONAL

    Source sequence(s)
    BC172048
    Consensus CDS
    CCDS48420.1
    UniProtKB/Swiss-Prot
    B2RXM4
    Related
    ENSMUSP00000124211.2, ENSMUST00000159679.8
    Conserved Domains (1) summary
    cl17173
    Location:63 → 277
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    163529415..163552801 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164867.1 → XP_036020760.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X3

    Conserved Domains (1) summary
    cl17173
    Location:17 → 183
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_036164856.1 → XP_036020749.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X1

    Conserved Domains (1) summary
    cl17173
    Location:47 → 261
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_036164864.1 → XP_036020757.1  N-terminal Xaa-Pro-Lys N-methyltransferase 2 isoform X2

    Conserved Domains (1) summary
    cl17173
    Location:2 → 212
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RXM4.1 GenPept UniProtKB/Swiss-Prot:B2RXM4

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