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Zbtb37 zinc finger and BTB domain containing 37 [ Mus musculus (house mouse) ]

Gene ID: 240869, updated on 5-Mar-2024

Summary

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Official Symbol
Zbtb37provided by MGI
Official Full Name
zinc finger and BTB domain containing 37provided by MGI
Primary source
MGI:MGI:2444467
See related
Ensembl:ENSMUSG00000043467 AllianceGenome:MGI:2444467
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D430004I08Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. Is expressed in early conceptus and genitourinary system. Orthologous to human ZBTB37 (zinc finger and BTB domain containing 37). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
1 H2.1; 1 69.75 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (160830492..160862432, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161002922..161034864, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:162836371-162836672 Neighboring gene RING CCCH (C3H) domains 1 Neighboring gene serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 Neighboring gene predicted gene, 57574 Neighboring gene STARR-positive B cell enhancer mm9_chr1:162964993-162965294 Neighboring gene predicted gene, 26224 Neighboring gene predicted gene, 22489 Neighboring gene growth arrest specific 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  2. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356489.1 → NP_001343418.1  zinc finger and BTB domain-containing protein 37

    Status: VALIDATED

    Source sequence(s)
    AC163327
    Consensus CDS
    CCDS15412.1
    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Related
    ENSMUSP00000125417.3, ENSMUST00000159250.9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  2. NM_173424.4 → NP_775600.1  zinc finger and BTB domain-containing protein 37

    See identical proteins and their annotated locations for NP_775600.1

    Status: VALIDATED

    Source sequence(s)
    AC163327
    Consensus CDS
    CCDS15412.1
    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Related
    ENSMUSP00000125253.3, ENSMUST00000162226.9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_151478.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163327

  2. NR_151479.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163327

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    160830492..160862432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164847.1 → XP_036020740.1  zinc finger and BTB domain-containing protein 37 isoform X3

    UniProtKB/TrEMBL
    F7ALN1
    Conserved Domains (1) summary
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  2. XM_030254006.2 → XP_030109866.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  3. XM_030254021.2 → XP_030109881.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  4. XM_030254007.2 → XP_030109867.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  5. XM_030254027.2 → XP_030109887.1  zinc finger and BTB domain-containing protein 37 isoform X3

    UniProtKB/TrEMBL
    F7ALN1
    Conserved Domains (1) summary
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  6. XM_030254014.2 → XP_030109874.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  7. XM_036164844.1 → XP_036020737.1  zinc finger and BTB domain-containing protein 37 isoform X3

    UniProtKB/TrEMBL
    F7ALN1
    Conserved Domains (1) summary
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  8. XM_030254009.2 → XP_030109869.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  9. XM_036164845.1 → XP_036020738.1  zinc finger and BTB domain-containing protein 37 isoform X3

    UniProtKB/TrEMBL
    F7ALN1
    Related
    ENSMUSP00000129965.3, ENSMUST00000171748.3
    Conserved Domains (1) summary
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  10. XM_011238812.3 → XP_011237114.1  zinc finger and BTB domain-containing protein 37 isoform X1

    See identical proteins and their annotated locations for XP_011237114.1

    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  11. XM_011238815.3 → XP_011237117.1  zinc finger and BTB domain-containing protein 37 isoform X1

    See identical proteins and their annotated locations for XP_011237117.1

    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  12. XM_030254017.2 → XP_030109877.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  13. XM_036164829.1 → XP_036020722.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  14. XM_030254010.2 → XP_030109870.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  15. XM_030254019.2 → XP_030109879.1  zinc finger and BTB domain-containing protein 37 isoform X1

    UniProtKB/TrEMBL
    Q14CI5, Q3UFR3, Q3ULY8, Q8C3U9
    Conserved Domains (4) summary
    sd00017
    Location:377 → 397
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
    pfam00096
    Location:403 → 425
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 440
    zf-H2C2_2; Zinc-finger double domain

  16. XM_036164837.1 → XP_036020730.1  zinc finger and BTB domain-containing protein 37 isoform X2

    Conserved Domains (1) summary
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

  17. XM_036164836.1 → XP_036020729.1  zinc finger and BTB domain-containing protein 37 isoform X2

    Conserved Domains (1) summary
    cd18222
    Location:9 → 131
    BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
Nucleotide Protein Strain
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