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Kcnt2 potassium channel, subfamily T, member 2 [ Mus musculus (house mouse) ]

Gene ID: 240776, updated on 2-Apr-2024

Summary

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Official Symbol
Kcnt2provided by MGI
Official Full Name
potassium channel, subfamily T, member 2provided by MGI
Primary source
MGI:MGI:3036273
See related
Ensembl:ENSMUSG00000052726 AllianceGenome:MGI:3036273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Slick; E330038N15Rik
Summary
Predicted to enable chloride-activated potassium channel activity; intracellular sodium activated potassium channel activity; and outward rectifier potassium channel activity. Predicted to be involved in potassium ion export across plasma membrane. Predicted to act upstream of or within potassium ion transport. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Is expressed in forebrain. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 57. Orthologous to human KCNT2 (potassium sodium-activated channel subfamily T member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 2.5), frontal lobe adult (RPKM 1.6) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnt2 in Genome Data Viewer
Location:
1 F; 1 61.62 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (140173373..140541783)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (140245657..140614045)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26048 Neighboring gene STARR-seq mESC enhancer starr_02496 Neighboring gene STARR-seq mESC enhancer starr_02497 Neighboring gene complement component factor h Neighboring gene STARR-seq mESC enhancer starr_02498 Neighboring gene STARR-seq mESC enhancer starr_02500 Neighboring gene RIKEN cDNA 4930590L20 gene Neighboring gene STARR-seq mESC enhancer starr_02501 Neighboring gene STARR-seq mESC enhancer starr_02502 Neighboring gene STARR-seq mESC enhancer starr_02503 Neighboring gene STARR-seq mESC enhancer starr_02505 Neighboring gene STARR-seq mESC enhancer starr_02507 Neighboring gene STARR-seq mESC enhancer starr_02508 Neighboring gene STARR-seq mESC enhancer starr_02509 Neighboring gene glutathione S-transferase, mu 4 pseudogene Neighboring gene glutathione S-transferase, mu 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. Liu B, et al. Nat Commun, 2020 Aug 14. PMID 32796851, Free PMC Article
  2. Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice. Reijntjes DOJ, et al. Sci Rep, 2019 Feb 22. PMID 30796290, Free PMC Article
  3. Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning. Wojtovich AP, et al. Anesthesiology, 2016 May. PMID 26845140, Free PMC Article
  4. Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain. Rizzi S, et al. J Comp Neurol, 2016 Jul 1. PMID 26587966, Free PMC Article
  5. Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons. Yang B, et al. J Neurosci, 2007 Mar 7. PMID 17344399, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.
    Title: An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.
  2. Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.
    Title: Sodium-activated potassium channels shape peripheral auditory function and activity of the primary auditory neurons in mice.
  3. This study showed that the Intense Slick channel immunoreactivity was observed in processes, varicosities, and neuronal cell bodies of the olfactory bulb, granular zones of cortical regions, hippocampus, amygdala, lateral septal nuclei, certain hypothalamic and midbrain nuclei, and several regions of the brainstem.
    Title: Differential distribution of the sodium-activated potassium channels slick and slack in mouse brain.
  4. Slick (Slo2.1) is required for both volatile anesthetics-stimulated K flux and for the anesthetic preconditioning-induced cardioprotection
    Title: Cardiac Slo2.1 Is Required for Volatile Anesthetic Stimulation of K+ Transport and Anesthetic Preconditioning.
  5. Slick and Slack are expressed at high levels auditory brainstem. Activation of these KNa channels allows temporal accuracy of firing to be increased at high frequencies of stimulation.
    Title: Slack and Slick K(Na) channels regulate the accuracy of timing of auditory neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride-activated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables intracellular sodium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in potassium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
potassium channel subfamily T member 2
Names
sodium- and chloride-activated ATP-sensitive potassium channel subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081027.3 → NP_001074496.2  potassium channel subfamily T member 2

    Status: VALIDATED

    Source sequence(s)
    AC120400, AC156607, AC156989
    Consensus CDS
    CCDS48389.1
    UniProtKB/TrEMBL
    D3Z649
    Related
    ENSMUSP00000113333.2, ENSMUST00000120796.8
    Conserved Domains (2) summary
    pfam03493
    Location:431 → 526
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:226 → 272
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    140173373..140541783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247999.3 → XP_011246301.1  potassium channel subfamily T member 2 isoform X14

    Conserved Domains (3) summary
    pfam00520
    Location:140 → 295
    Ion_trans; Ion transport protein
    pfam03493
    Location:456 → 558
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:242 → 297
    Ion_trans_2; Ion channel

  2. XM_017320510.2 → XP_017175999.1  potassium channel subfamily T member 2 isoform X9

    Conserved Domains (3) summary
    pfam00520
    Location:140 → 295
    Ion_trans; Ion transport protein
    pfam03493
    Location:456 → 558
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:242 → 297
    Ion_trans_2; Ion channel

  3. XM_017320506.2 → XP_017175995.1  potassium channel subfamily T member 2 isoform X1

    Conserved Domains (3) summary
    pfam00520
    Location:140 → 295
    Ion_trans; Ion transport protein
    pfam03493
    Location:456 → 558
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:242 → 297
    Ion_trans_2; Ion channel

  4. XM_017320508.2 → XP_017175997.1  potassium channel subfamily T member 2 isoform X5

    Conserved Domains (3) summary
    pfam00520
    Location:140 → 295
    Ion_trans; Ion transport protein
    pfam03493
    Location:456 → 558
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:242 → 297
    Ion_trans_2; Ion channel

  5. XM_006529562.4 → XP_006529625.1  potassium channel subfamily T member 2 isoform X3

    Conserved Domains (3) summary
    pfam00520
    Location:140 → 295
    Ion_trans; Ion transport protein
    pfam03493
    Location:456 → 551
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:242 → 297
    Ion_trans_2; Ion channel

  6. XM_011247997.3 → XP_011246299.1  potassium channel subfamily T member 2 isoform X10

    Conserved Domains (3) summary
    pfam00520
    Location:140 → 295
    Ion_trans; Ion transport protein
    pfam07885
    Location:242 → 297
    Ion_trans_2; Ion channel
    cl29357
    Location:456 → 496
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit

  7. XM_006529567.2 → XP_006529630.1  potassium channel subfamily T member 2 isoform X12

    Conserved Domains (2) summary
    pfam00520
    Location:140 → 295
    Ion_trans; Ion transport protein
    pfam07885
    Location:242 → 297
    Ion_trans_2; Ion channel

  8. XM_006529572.4 → XP_006529635.1  potassium channel subfamily T member 2 isoform X17

    Conserved Domains (2) summary
    pfam03493
    Location:431 → 526
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:205 → 272
    Ion_trans_2; Ion channel

  9. XM_017320507.2 → XP_017175996.1  potassium channel subfamily T member 2 isoform X2

    Conserved Domains (3) summary
    pfam00520
    Location:140 → 295
    Ion_trans; Ion transport protein
    pfam03493
    Location:456 → 558
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:242 → 297
    Ion_trans_2; Ion channel

  10. XM_017320509.2 → XP_017175998.1  potassium channel subfamily T member 2 isoform X6

    Conserved Domains (2) summary
    pfam03493
    Location:431 → 533
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:205 → 272
    Ion_trans_2; Ion channel

  11. XM_006529565.4 → XP_006529628.1  potassium channel subfamily T member 2 isoform X8

    Conserved Domains (2) summary
    pfam03493
    Location:431 → 526
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:205 → 272
    Ion_trans_2; Ion channel

  12. XM_030253999.2 → XP_030109859.1  potassium channel subfamily T member 2 isoform X4

    Conserved Domains (3) summary
    pfam00520
    Location:140 → 295
    Ion_trans; Ion transport protein
    pfam03493
    Location:456 → 551
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:242 → 297
    Ion_trans_2; Ion channel

  13. XM_011247996.4 → XP_011246298.1  potassium channel subfamily T member 2 isoform X7

    Conserved Domains (2) summary
    pfam03493
    Location:431 → 533
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:205 → 272
    Ion_trans_2; Ion channel

  14. XM_011247998.4 → XP_011246300.1  potassium channel subfamily T member 2 isoform X13

    UniProtKB/TrEMBL
    D3Z592
    Related
    ENSMUSP00000113535.2, ENSMUST00000119786.8
    Conserved Domains (2) summary
    pfam07885
    Location:205 → 272
    Ion_trans_2; Ion channel
    cl29357
    Location:431 → 471
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit

  15. XM_006529566.5 → XP_006529629.1  potassium channel subfamily T member 2 isoform X11

    UniProtKB/TrEMBL
    D3YTU6
    Related
    ENSMUSP00000112887.2, ENSMUST00000120709.8
    Conserved Domains (2) summary
    pfam03493
    Location:431 → 526
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:205 → 272
    Ion_trans_2; Ion channel

  16. XM_036164770.1 → XP_036020663.1  potassium channel subfamily T member 2 isoform X16

    Conserved Domains (1) summary
    pfam03493
    Location:1 → 87
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit

  17. XM_017320512.2 → XP_017176001.1  potassium channel subfamily T member 2 isoform X15

    Conserved Domains (1) summary
    pfam03493
    Location:1 → 90
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit

RNA

  1. XR_004942432.1 RNA Sequence

  2. XR_001784494.2 RNA Sequence

  3. XR_001784498.2 RNA Sequence

  4. XR_001784492.2 RNA Sequence

  5. XR_001784491.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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