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Klhl12 kelch-like 12 [ Mus musculus (house mouse) ]

Gene ID: 240756, updated on 5-Mar-2024

Summary

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Official Symbol
Klhl12provided by MGI
Official Full Name
kelch-like 12provided by MGI
Primary source
MGI:MGI:2385619
See related
Ensembl:ENSMUSG00000026455 AllianceGenome:MGI:2385619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C3ip1
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including COPII vesicle coating; mesenchymal cell differentiation; and protein monoubiquitination. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in centriolar satellite and intracellular membrane-bounded organelle. Predicted to be part of COPII vesicle coat and Cul3-RING ubiquitin ligase complex. Predicted to be active in COPII-coated ER to Golgi transport vesicle. Is expressed in genitourinary system. Orthologous to human KLHL12 (kelch like family member 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 12.6), liver E14 (RPKM 11.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 58.23 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (134383269..134418611)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134455495..134490880)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02328 Neighboring gene cytochrome b5 reductase 1 Neighboring gene adiponectin receptor 1 Neighboring gene STARR-seq mESC enhancer starr_02333 Neighboring gene STARR-positive B cell enhancer ABC_E3304 Neighboring gene RAB interacting factor Neighboring gene predicted gene, 25612 Neighboring gene tubulin alpha 5, pseudogene Neighboring gene predicted gene 15454

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase. Rondou P, et al. J Biol Chem, 2008 Apr 25. PMID 18303015, Free PMC Article
  2. Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein. Funato Y, et al. Curr Biol, 2010 Nov 9. PMID 20970343
  3. Spatiotemporal structure of cell fate decisions in murine neural crest. Soldatov R, et al. Science, 2019 Jun 7. PMID 31171666
  4. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  5. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC7076

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in COPII vesicle coating IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in COPII vesicle coating ISO
Inferred from Sequence Orthology
more info
  
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest cell development ISO
Inferred from Sequence Orthology
more info
  
involved_in neural crest formation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPII vesicle coat ISO
Inferred from Sequence Orthology
more info
  
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in COPII-coated ER to Golgi transport vesicle ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kelch-like protein 12
Names
CUL3-interacting protein 1
kelch-like protein C3IP1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311136.2 → NP_001298065.1  kelch-like protein 12 isoform 1

    See identical proteins and their annotated locations for NP_001298065.1

    Status: VALIDATED

    Source sequence(s)
    AC122771, AC131592
    Consensus CDS
    CCDS78687.1
    UniProtKB/Swiss-Prot
    Q8BZM0, Q8K225
    Related
    ENSMUSP00000027725.5, ENSMUST00000027725.11
    Conserved Domains (4) summary
    PHA03098
    Location:46 → 550
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:416 → 459
    Kelch; KELCH repeat [structural motif]
    cd18242
    Location:12 → 135
    BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
    cd18452
    Location:130 → 265
    BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

  2. NM_001421130.1 → NP_001408059.1  kelch-like protein 12 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122771, AC131592
    UniProtKB/Swiss-Prot
    Q8BZM0, Q8K225

  3. NM_001421132.1 → NP_001408061.1  kelch-like protein 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122771, AC131592

  4. NM_001421133.1 → NP_001408062.1  kelch-like protein 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122771, AC131592

  5. NM_001421134.1 → NP_001408063.1  kelch-like protein 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC122771, AC131592

  6. NM_001421135.1 → NP_001408064.1  kelch-like protein 12 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC122771, AC131592

  7. NM_001421136.1 → NP_001408065.1  kelch-like protein 12 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122771, AC131592

  8. NM_001421137.1 → NP_001408066.1  kelch-like protein 12 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC122771, AC131592

  9. NM_153128.4 → NP_694768.1  kelch-like protein 12 isoform 2

    See identical proteins and their annotated locations for NP_694768.1

    Status: VALIDATED

    Source sequence(s)
    AC122771, AC131592
    Consensus CDS
    CCDS35715.1
    UniProtKB/Swiss-Prot
    Q8BZM0
    Related
    ENSMUSP00000107851.2, ENSMUST00000112232.8
    Conserved Domains (5) summary
    smart00612
    Location:494 → 538
    Kelch; Kelch domain
    PHA03098
    Location:46 → 523
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:319 → 365
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:23 → 126
    BTB; BTB/POZ domain
    pfam07707
    Location:135 → 236
    BACK; BTB And C-terminal Kelch

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    134383269..134418611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZM0.1 GenPept UniProtKB/Swiss-Prot:Q8BZM0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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