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Plekha6 pleckstrin homology domain containing, family A member 6 [ Mus musculus (house mouse) ]

Gene ID: 240753, updated on 5-Mar-2024

Summary

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Official Symbol
Plekha6provided by MGI
Official Full Name
pleckstrin homology domain containing, family A member 6provided by MGI
Primary source
MGI:MGI:2388662
See related
Ensembl:ENSMUSG00000041757 AllianceGenome:MGI:2388662
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pepp3; 9530028L01Rik
Summary
Orthologous to human PLEKHA6 (pleckstrin homology domain containing A6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon adult (RPKM 32.2), kidney adult (RPKM 14.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 57.91 cM
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133089770..133231173)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (133162032..133303435)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta Neighboring gene predicted gene, 51647 Neighboring gene STARR-seq mESC enhancer starr_02276 Neighboring gene protein phosphatase 1, regulatory subunit 15B Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135055920-135056124 Neighboring gene VISTA enhancer mm971 Neighboring gene VISTA enhancer mm1460 Neighboring gene STARR-seq mESC enhancer starr_02278 Neighboring gene STARR-seq mESC enhancer starr_02279 Neighboring gene predicted gene, 51648 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:135134303-135134461 Neighboring gene predicted gene, 19461 Neighboring gene STARR-seq mESC enhancer starr_02280 Neighboring gene golgi transport 1A Neighboring gene predicted gene, 53474 Neighboring gene KiSS-1 metastasis-suppressor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Maternal DNA Methylation Regulates Early Trophoblast Development. Branco MR, et al. Dev Cell, 2016 Jan 25. PMID 26812015, Free PMC Article
  2. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article
  3. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
  4. Vti1b promotes TRPV1 sensitization during inflammatory pain. Sondermann JR, et al. Pain, 2019 Feb. PMID 30335684
  5. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
pleckstrin homology domain-containing family A member 6
Names
PEPP-3
PH domain-containing family A member 6
phosphoinositol 3-phosphate-binding protein-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160268.1 → NP_001153740.1  pleckstrin homology domain-containing family A member 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has several internal in-frame differences compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC158577, AK173074, BB845730
    Consensus CDS
    CCDS48361.1
    UniProtKB/TrEMBL
    A0A087WRB7, E9PX43
    Related
    ENSMUSP00000100703.3, ENSMUST00000105082.9
    Conserved Domains (2) summary
    cd13248
    Location:54 → 177
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:60 → 178
    PH; PH domain

  2. NM_182930.2 → NP_891846.1  pleckstrin homology domain-containing family A member 6 isoform 1

    See identical proteins and their annotated locations for NP_891846.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC158577, BB845730, BC054547
    Consensus CDS
    CCDS15292.1
    UniProtKB/Swiss-Prot
    Q7TQG1, Q8K0J5
    UniProtKB/TrEMBL
    A0A087WRB7
    Related
    ENSMUSP00000048214.9, ENSMUST00000038295.15
    Conserved Domains (3) summary
    PRK14086
    Location:232 → 402
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:54 → 157
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:594 → 740
    Mplasa_alph_rch; helix-rich Mycoplasma protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133089770..133231173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529534.4 → XP_006529597.1  pleckstrin homology domain-containing family A member 6 isoform X1

    UniProtKB/TrEMBL
    Q69ZU4
    Conserved Domains (4) summary
    PRK14086
    Location:364 → 526
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:158 → 281
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:718 → 864
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam00397
    Location:10 → 39
    WW; WW domain

  2. XM_017320501.2 → XP_017175990.1  pleckstrin homology domain-containing family A member 6 isoform X3

    UniProtKB/TrEMBL
    Q69ZU4
    Conserved Domains (4) summary
    PRK14086
    Location:356 → 526
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:158 → 281
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:718 → 864
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam00397
    Location:10 → 39
    WW; WW domain

  3. XM_036164711.1 → XP_036020604.1  pleckstrin homology domain-containing family A member 6 isoform X4

    UniProtKB/TrEMBL
    Q69ZU4
    Conserved Domains (4) summary
    PRK14086
    Location:356 → 526
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:158 → 281
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:658 → 837
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam00397
    Location:10 → 39
    WW; WW domain

  4. XM_036164712.1 → XP_036020605.1  pleckstrin homology domain-containing family A member 6 isoform X5

    UniProtKB/TrEMBL
    Q69ZU4
    Conserved Domains (4) summary
    PRK14086
    Location:356 → 526
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:158 → 281
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:700 → 846
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam00397
    Location:10 → 39
    WW; WW domain

  5. XM_006529547.4 → XP_006529610.1  pleckstrin homology domain-containing family A member 6 isoform X7

    UniProtKB/TrEMBL
    Q69ZU4
    Conserved Domains (5) summary
    PHA03247
    Location:286 → 664
    PHA03247; large tegument protein UL36; Provisional
    PRK14086
    Location:356 → 526
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:158 → 281
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:673 → 819
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam00397
    Location:10 → 39
    WW; WW domain

  6. XM_036164721.1 → XP_036020614.1  pleckstrin homology domain-containing family A member 6 isoform X6

    UniProtKB/TrEMBL
    Q69ZU4
    Conserved Domains (4) summary
    PRK14086
    Location:356 → 526
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:158 → 281
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:671 → 817
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam00397
    Location:10 → 39
    WW; WW domain

  7. XM_006529553.4 → XP_006529616.1  pleckstrin homology domain-containing family A member 6 isoform X9

    UniProtKB/TrEMBL
    Q69ZU4
    Conserved Domains (4) summary
    PRK14086
    Location:356 → 526
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:158 → 281
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:644 → 790
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam00397
    Location:10 → 39
    WW; WW domain

  8. XM_006529536.4 → XP_006529599.1  pleckstrin homology domain-containing family A member 6 isoform X2

    UniProtKB/TrEMBL
    A0A087WRB7
    Conserved Domains (4) summary
    PRK14086
    Location:336 → 506
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:158 → 261
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:698 → 844
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam00397
    Location:10 → 39
    WW; WW domain

  9. XM_006529554.4 → XP_006529617.1  pleckstrin homology domain-containing family A member 6 isoform X10

    UniProtKB/TrEMBL
    A0A087WRB7
    Conserved Domains (4) summary
    PRK14086
    Location:336 → 506
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:158 → 261
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:624 → 770
    Mplasa_alph_rch; helix-rich Mycoplasma protein
    pfam00397
    Location:10 → 39
    WW; WW domain

  10. XM_036164730.1 → XP_036020623.1  pleckstrin homology domain-containing family A member 6 isoform X8

    UniProtKB/Swiss-Prot
    Q7TQG1, Q8K0J5
    UniProtKB/TrEMBL
    A0A087WRB7
    Conserved Domains (3) summary
    PRK14086
    Location:232 → 402
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:54 → 157
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:594 → 740
    Mplasa_alph_rch; helix-rich Mycoplasma protein

  11. XM_036164736.1 → XP_036020629.1  pleckstrin homology domain-containing family A member 6 isoform X12

    UniProtKB/TrEMBL
    A0A087WRB7
    Conserved Domains (3) summary
    PRK14086
    Location:232 → 402
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:54 → 157
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:549 → 695
    Mplasa_alph_rch; helix-rich Mycoplasma protein

  12. XM_030253991.1 → XP_030109851.1  pleckstrin homology domain-containing family A member 6 isoform X11

    UniProtKB/TrEMBL
    A0A087WRB7
    Conserved Domains (3) summary
    PRK14086
    Location:232 → 402
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:54 → 157
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:547 → 693
    Mplasa_alph_rch; helix-rich Mycoplasma protein

  13. XM_036164737.1 → XP_036020630.1  pleckstrin homology domain-containing family A member 6 isoform X13

    UniProtKB/TrEMBL
    A0A087WRB7
    Conserved Domains (3) summary
    PRK14086
    Location:232 → 402
    dnaA; chromosomal replication initiator protein DnaA
    cd13248
    Location:54 → 157
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR04523
    Location:508 → 643
    Mplasa_alph_rch; helix-rich Mycoplasma protein

RNA

  1. XR_003955328.1 RNA Sequence

  2. XR_387170.4 RNA Sequence

  3. XR_003955340.1 RNA Sequence

  4. XR_003955331.1 RNA Sequence

  5. XR_003955329.1 RNA Sequence

  6. XR_003955337.1 RNA Sequence

  7. XR_003955343.1 RNA Sequence

  8. XR_003955339.1 RNA Sequence

  9. XR_003955344.1 RNA Sequence

  10. XR_003955346.1 RNA Sequence

  11. XR_003955330.1 RNA Sequence

  12. XR_003955348.1 RNA Sequence

  13. XR_003955354.1 RNA Sequence

  14. XR_004942426.1 RNA Sequence

  15. XR_004942424.1 RNA Sequence

  16. XR_004942427.1 RNA Sequence

  17. XR_003955359.1 RNA Sequence

  18. XR_004942428.1 RNA Sequence

  19. XR_003955356.2 RNA Sequence

  20. XR_004942421.1 RNA Sequence

  21. XR_004942420.1 RNA Sequence

  22. XR_003955349.2 RNA Sequence

  23. XR_003955362.2 RNA Sequence

  24. XR_003955353.2 RNA Sequence

  25. XR_003955352.2 RNA Sequence

  26. XR_003955355.2 RNA Sequence

  27. XR_003955345.2 RNA Sequence

  28. XR_003955342.2 RNA Sequence

  29. XR_003955357.1 RNA Sequence

  30. XR_003955341.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQG1.1 GenPept UniProtKB/Swiss-Prot:Q7TQG1

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