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Sra1 steroid receptor RNA activator 1 [ Mus musculus (house mouse) ]

Gene ID: 24068, updated on 5-Mar-2024

Summary

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Official Symbol
Sra1provided by MGI
Official Full Name
steroid receptor RNA activator 1provided by MGI
Primary source
MGI:MGI:1344414
See related
Ensembl:ENSMUSG00000006050 AllianceGenome:MGI:1344414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sra; Srap; Straa1; Strra1
Summary
Enables DNA binding activity and nuclear receptor coactivator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cell leading edge. Part of transcription regulator complex. Is expressed in genitourinary system. Orthologous to human SRA1 (steroid receptor RNA activator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 32.5), adrenal adult (RPKM 29.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B2; 18 19.46 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (36800240..36803364, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (36667187..36670311, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5653 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene STARR-positive B cell enhancer ABC_E8708 Neighboring gene Riken cDNA E230025N22 gene Neighboring gene amyloid beta precursor protein binding family B member 3 Neighboring gene solute carrier family 35, member A4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Scavenger receptor SRA attenuates microglia activation and protects neuroinflammatory injury in intracerebral hemorrhage. Yang Z, et al. J Neuroimmunol, 2015 Jan 15. PMID 25481196
  2. SRA gene knockout protects against diet-induced obesity and improves glucose tolerance. Liu S, et al. J Biol Chem, 2014 May 9. PMID 24675075, Free PMC Article
  3. Steroid Receptor RNA Activator, a Long Noncoding RNA, Activates p38, Facilitates Epithelial-Mesenchymal Transformation, and Mediates Experimental Melanoma Metastasis. Hong CH, et al. J Invest Dermatol, 2020 Jul. PMID 31945347
  4. RNA helicase Ddx5 and the noncoding RNA SRA act as coactivators in the Notch signaling pathway. Jung C, et al. Biochim Biophys Acta, 2013 May. PMID 23396200
  5. LncRNA SRA promotes hepatic steatosis through repressing the expression of adipose triglyceride lipase (ATGL). Chen G, et al. Sci Rep, 2016 Oct 19. PMID 27759039, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Steroid Receptor RNA Activator, a Long Noncoding RNA, Activates p38, Facilitates Epithelial-Mesenchymal Transformation, and Mediates Experimental Melanoma Metastasis.
    Title: Steroid Receptor RNA Activator, a Long Noncoding RNA, Activates p38, Facilitates Epithelial-Mesenchymal Transformation, and Mediates Experimental Melanoma Metastasis.
  2. Visfatin upregulated CD36 and SRA expression and downregulated ABCA1 and ABCG1 expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK-dependent pathways.
    Title: VISFATIN PROMOTES FOAM CELL FORMATION BY DYSREGULATING CD36, SRA, ABCA1, AND ABCG1 EXPRESSION IN RAW264.7 MACROPHAGES.
  3. The results of this study demonstrated that SRA could attenuate microglia mediated inflammation injury in ICH. In addition, SRA mediated negative feedback mechanism in neuroimmune homeostasis.
    Title: Scavenger receptor SRA attenuates microglia activation and protects neuroinflammatory injury in intracerebral hemorrhage.
  4. these data are the first to indicate a functional role for SRA in adipose tissue biology and glucose homeostasis in vivo.
    Title: SRA gene knockout protects against diet-induced obesity and improves glucose tolerance.
  5. Dax1 augmentation of LRH-1-mediated Oct4 activation is dependent upon steroid receptor RNA activator
    Title: Dax1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA.
  6. DEAD-box RNA helicase p68 (DDX5) and its associated noncoding RNA, steroid receptor RNA activator (SRA), form a complex with CTCF that is essential for insulator function
    Title: Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA.
  7. These findings reveal novel functions of SRA and Dax-1 in steroidogenesis and adrenal biology.
    Title: Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis.
  8. Results identify a pseudouridine synthase, mPus1p, as a coactivator for retinoic acid receptor (mRAR)gamma when coexpressed with steroid receptor RNA activator.
    Title: Regulation of nuclear receptor activity by a pseudouridine synthase through posttranscriptional modification of steroid receptor RNA activator.
  9. Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo
    Title: Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
  
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coregulator activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to estrogen stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
part_of SCAR complex ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of steroid hormone aporeceptor complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
steroid receptor RNA activator 1
Names
steroid receptor RNA activator protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164406.1 → NP_001157878.1  steroid receptor RNA activator 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform b, which has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK010375, BQ748094, BY097874
    UniProtKB/Swiss-Prot
    Q80VJ2
    Conserved Domains (1) summary
    pfam07304
    Location:78 → 130
    SRA1; Steroid receptor RNA activator (SRA1)

  2. NM_025291.3 → NP_079567.2  steroid receptor RNA activator 1 isoform a

    See identical proteins and their annotated locations for NP_079567.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK010375, BQ748094, BY097874
    Consensus CDS
    CCDS29156.2
    UniProtKB/TrEMBL
    A0A8Q0Q6H9, G3X8R2
    Related
    ENSMUSP00000133360.2, ENSMUST00000173875.9
    Conserved Domains (1) summary
    pfam07304
    Location:78 → 215
    SRA1; Steroid receptor RNA activator (SRA1)

RNA

  1. NR_028355.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK010375, BQ748094, BX516162, BY097874
    Related
    ENSMUST00000173482.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    36800240..36803364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VJ2.4 GenPept UniProtKB/Swiss-Prot:Q80VJ2

Gene LinkOut

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