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Ccnj cyclin J [ Mus musculus (house mouse) ]

Gene ID: 240665, updated on 5-Mar-2024

Summary

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Official Symbol
Ccnjprovided by MGI
Official Full Name
cyclin Jprovided by MGI
Primary source
MGI:MGI:2443297
See related
Ensembl:ENSMUSG00000025010 AllianceGenome:MGI:2443297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D430039C20Rik
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition and regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. Orthologous to human CCNJ (cyclin J). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.4), whole brain E14.5 (RPKM 8.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ccnj in Genome Data Viewer
Location:
19 C3; 19 34.26 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (40819345..40837016)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (40830959..40848572)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ectonucleoside triphosphate diphosphohydrolase 1 Neighboring gene predicted gene, 41846 Neighboring gene coiled-coil and C2 domain containing 2B Neighboring gene STARR-seq mESC enhancer starr_46135 Neighboring gene STARR-positive B cell enhancer mm9_chr19:40895901-40896202 Neighboring gene predicted gene, 33482 Neighboring gene RIKEN cDNA E030044B06 gene Neighboring gene STARR-seq mESC enhancer starr_46136 Neighboring gene predicted gene, 57494 Neighboring gene zinc finger protein 518A Neighboring gene microRNA 8092

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Exploration of the cell-cycle genes found within the RIKEN FANTOM2 data set. Forrest AR, et al. Genome Res, 2003 Jun. PMID 12819135, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC118445

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitotic cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cyclin-J

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172839.4 → NP_766427.1  cyclin-J

    See identical proteins and their annotated locations for NP_766427.1

    Status: VALIDATED

    Source sequence(s)
    AC117253
    Consensus CDS
    CCDS29806.1
    UniProtKB/Swiss-Prot
    Q1ED41, Q3TZI6, Q8BIY5
    Related
    ENSMUSP00000025983.7, ENSMUST00000025983.13
    Conserved Domains (2) summary
    cd20528
    Location:34 → 140
    CYCLIN_CCNJ-like_rpt1; first cyclin box found in cyclin-J (CCNJ) family
    cd20529
    Location:145 → 245
    CYCLIN_CCNJ-like_rpt2; second cyclin box found in cyclin-J (CCNJ) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    40819345..40837016
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161597.1 → XP_036017490.1  cyclin-J isoform X1

    UniProtKB/Swiss-Prot
    Q1ED41, Q3TZI6, Q8BIY5
    Conserved Domains (2) summary
    cd20528
    Location:34 → 140
    CYCLIN_CCNJ-like_rpt1; first cyclin box found in cyclin-J (CCNJ) family
    cd20529
    Location:145 → 245
    CYCLIN_CCNJ-like_rpt2; second cyclin box found in cyclin-J (CCNJ) family

  2. XM_030250940.1 → XP_030106800.1  cyclin-J isoform X2

    Conserved Domains (2) summary
    pfam00134
    Location:15 → 109
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:145 → 284
    Cyclin_C; Cyclin, C-terminal domain

  3. XM_036161596.1 → XP_036017489.1  cyclin-J isoform X1

    UniProtKB/Swiss-Prot
    Q1ED41, Q3TZI6, Q8BIY5
    Conserved Domains (2) summary
    cd20528
    Location:34 → 140
    CYCLIN_CCNJ-like_rpt1; first cyclin box found in cyclin-J (CCNJ) family
    cd20529
    Location:145 → 245
    CYCLIN_CCNJ-like_rpt2; second cyclin box found in cyclin-J (CCNJ) family

  4. XM_006527088.4 → XP_006527151.1  cyclin-J isoform X2

    Conserved Domains (2) summary
    pfam00134
    Location:15 → 109
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:145 → 284
    Cyclin_C; Cyclin, C-terminal domain

  5. XM_011247248.3 → XP_011245550.1  cyclin-J isoform X3

    See identical proteins and their annotated locations for XP_011245550.1

    UniProtKB/Swiss-Prot
    Q3TZI6
    Conserved Domains (2) summary
    pfam00134
    Location:15 → 109
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:145 → 283
    Cyclin_C; Cyclin, C-terminal domain

  6. XM_017318200.3 → XP_017173689.1  cyclin-J isoform X1

    UniProtKB/Swiss-Prot
    Q1ED41, Q3TZI6, Q8BIY5
    Related
    ENSMUSP00000112643.2, ENSMUST00000119316.2
    Conserved Domains (2) summary
    cd20528
    Location:34 → 140
    CYCLIN_CCNJ-like_rpt1; first cyclin box found in cyclin-J (CCNJ) family
    cd20529
    Location:145 → 245
    CYCLIN_CCNJ-like_rpt2; second cyclin box found in cyclin-J (CCNJ) family

  7. XM_030250941.2 → XP_030106801.1  cyclin-J isoform X3

    Conserved Domains (2) summary
    pfam00134
    Location:15 → 109
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:145 → 283
    Cyclin_C; Cyclin, C-terminal domain

  8. XM_036161595.1 → XP_036017488.1  cyclin-J isoform X1

    UniProtKB/Swiss-Prot
    Q1ED41, Q3TZI6, Q8BIY5
    Conserved Domains (2) summary
    cd20528
    Location:34 → 140
    CYCLIN_CCNJ-like_rpt1; first cyclin box found in cyclin-J (CCNJ) family
    cd20529
    Location:145 → 245
    CYCLIN_CCNJ-like_rpt2; second cyclin box found in cyclin-J (CCNJ) family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TZI6.2 GenPept UniProtKB/Swiss-Prot:Q3TZI6

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