Spry4 sprouty RTK signaling antagonist 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spry4provided by MGI
Official Full Name: sprouty RTK signaling antagonist 4provided by MGI
Primary source: MGI:MGI:1345144
See related: Ensembl:ENSMUSG00000024427 AllianceGenome:MGI:1345144
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: sprouty4; A030006O18Rik
Summary: Predicted to enable protein kinase inhibitor activity. Acts upstream of or within cellular response to leukemia inhibitory factor and negative regulation of MAP kinase activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; germ layer; and nervous system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 17 with or without anosmia. Orthologous to human SPRY4 (sprouty RTK signaling antagonist 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 10.0), limb E14.5 (RPKM 8.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B3; 18 20.5 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (38719300..38734400, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (38586247..38601347, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPRY4 inhibits and sensitizes the primary KIT mutants in gastrointestinal stromal tumors (GISTs) to imatinib.
Title: SPRY4 inhibits and sensitizes the primary KIT mutants in gastrointestinal stromal tumors (GISTs) to imatinib.
Macrophage Sprouty4 deficiency diminishes sepsis-induced acute lung injury in mice.
Title: Macrophage Sprouty4 deficiency diminishes sepsis-induced acute lung injury in mice.
Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling.
Title: Loss of Sprouty Produces a Ciliopathic Skeletal Phenotype in Mice Through Upregulation of Hedgehog Signaling.
A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice.
Title: A Sprouty4 reporter to monitor FGF/ERK signaling activity in ESCs and mice.
Irf6 and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 and RTK signaling pathway genes in human orofacial clefting populations.
Title: IRF6 and SPRY4 Signaling Interact in Periderm Development.
In the present study, it is demonstrated that Spry2 and -4 participate in KA induced neurodegeneration possibly through inhibition of ERK signaling.
Title: Sprouty2 and -4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage.
Autoregulatory loop between TGF-beta1/miR-411-5p/SPRY4 and p38 MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation.
Title: Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation.
in embryos with lower Spry2;Spry4 gene dosages, we observed a non-fusion of original R2 and M1 Shh signaling domains with consequent formation of a supernumerary tooth primordium from the isolated R2 bud
Title: Sprouty gene dosage influences temporal-spatial dynamics of primary enamel knot formation.
We demonstrate that in spry4-/- mice inflammatory responses, such TNFalpha secretion and macrophage/neutrophil invasion into the lesion site are reduced. In addition, astrocytic gliosis is attenuated and neuronal survival is increased.
Title: Decreased anti-regenerative effects after spinal cord injury in spry4-/- mice.
SPRY4 is a tumor suppressor at 5q whose disruption contributes to a lethal acute myeloid leukemia subtype.
Title: Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (6) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Spry4 (e-PCR), detects polymorphism
- UniSTS:547843

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein sprouty homolog 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011898.3 → NP_036028.2 protein sprouty homolog 4

See identical proteins and their annotated locations for NP_036028.2

Status: VALIDATED

Source sequence(s)

AC151580, AK034201, AK048122, BC050944

Consensus CDS

CCDS29202.1

UniProtKB/Swiss-Prot

Q543R1, Q9QXV7, Q9WTP2

Related

ENSMUSP00000025295.7, ENSMUST00000025295.8

Conserved Domains (1) summary

pfam05210
Location:165 → 267

Sprouty; Sprouty protein (Spry)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

38719300..38734400 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161148.1 → XP_036017041.1 protein sprouty homolog 4 isoform X1

UniProtKB/Swiss-Prot

Q543R1, Q9QXV7, Q9WTP2

Conserved Domains (1) summary

pfam05210
Location:165 → 267

Sprouty; Sprouty protein (Spry)