Spry1 sprouty RTK signaling antagonist 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Spry1provided by MGI
Official Full Name: sprouty RTK signaling antagonist 1provided by MGI
Primary source: MGI:MGI:1345139
See related: Ensembl:ENSMUSG00000037211 AllianceGenome:MGI:1345139
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: spry-1; sprouty1
Summary: Involved in negative regulation of cell differentiation and negative regulation of signal transduction. Acts upstream of or within several processes, including bud elongation involved in lung branching; kidney development; and negative regulation of signal transduction. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; branchial arch; embryo ectoderm; limb; and sensory organ. Orthologous to human SPRY1 (sprouty RTK signaling antagonist 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in lung adult (RPKM 52.2), genital fat pad adult (RPKM 23.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 B; 3 18.46 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (37694096..37698748)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (37639947..37644599)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcription factor Dmrt1 triggers the SPRY1-NF-kappaB pathway to maintain testicular immune homeostasis and male fertility.
Title: Transcription factor Dmrt1 triggers the SPRY1-NF-κB pathway to maintain testicular immune homeostasis and male fertility.
Increased SPRY1 expression activates NF-kappaB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis.
Title: Increased SPRY1 expression activates NF-κB signaling and promotes pancreatic cancer progression by recruiting neutrophils and macrophages through CXCL12-CXCR4 axis.
Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells.
Title: Sprouty1 has a protective role in atherogenesis and modifies the migratory and inflammatory phenotype of vascular smooth muscle cells.
METTL3/N6-methyladenosine/ miR-21-5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1/ERK/NF-kappaB pathway activation.
Title: METTL3/N6-methyladenosine/ miR-21-5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1/ERK/NF-κB pathway activation.
Sprouty1 regulates gonadal white adipose tissue growth through a PDGFRalpha/beta-Akt pathway.
Title: Sprouty1 regulates gonadal white adipose tissue growth through a PDGFRα/β-Akt pathway.
MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1.
Title: MiR-21-5p regulates extracellular matrix degradation and angiogenesis in TMJOA by targeting Spry1.
Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.
Title: Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.
that SPRY1 contributes to the regulation of CNS functions by influencing both neuronal differentiation under normal physiological processes and neuronal survival under pathological conditions
Title: Sprouty1 regulates neuritogenesis and survival of cortical neurons.
Tyrosine 53 is absolutely necessary for Sprouty1 function during genitourinary development in mice
Title: Sprouty1 Controls Genitourinary Development via its N-Terminal Tyrosine.
Our findings indicate that Spry1 is an important regulator of cardiomyocyte viability during ischemia-reperfusion injury
Title: Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury.

Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Spry1 (e-PCR), detects polymorphism
- UniSTS:547840

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in animal organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bud elongation involved in lung branching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in epithelial to mesenchymal transition involved in cardiac fibroblast development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within metanephros development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of GTPase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of MAP kinase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lens fiber cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neurotrophin TRK receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within organ induction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ureteric bud development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ureteric bud development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein sprouty homolog 1

Names: inhibitor of receptor tyrosine kinases; sprouty homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305440.1 → NP_001292369.1 protein sprouty homolog 1

See identical proteins and their annotated locations for NP_001292369.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4, encode the same protein.

Source sequence(s)

AC110508, AK140405, AV377285, BC051977

Consensus CDS

CCDS17322.1

UniProtKB/Swiss-Prot

Q9QXV9

UniProtKB/TrEMBL

Q53ZU1

Related

ENSMUSP00000103744.2, ENSMUST00000108109.8

Conserved Domains (1) summary

pfam05210
Location:181 → 278

Sprouty; Sprouty protein (Spry)
NM_001305441.1 → NP_001292370.1 protein sprouty homolog 1

See identical proteins and their annotated locations for NP_001292370.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4, encode the same protein.

Source sequence(s)

AC110508, AK140405, AV377285, BC051977

Consensus CDS

CCDS17322.1

UniProtKB/Swiss-Prot

Q9QXV9

UniProtKB/TrEMBL

Q53ZU1

Conserved Domains (1) summary

pfam05210
Location:181 → 278

Sprouty; Sprouty protein (Spry)
NM_001305442.1 → NP_001292371.1 protein sprouty homolog 1

See identical proteins and their annotated locations for NP_001292371.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate splice site and lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4, encode the same protein.

Source sequence(s)

AC110508, AK140405, AV377285, BC051977

Consensus CDS

CCDS17322.1

UniProtKB/Swiss-Prot

Q9QXV9

UniProtKB/TrEMBL

Q53ZU1

Conserved Domains (1) summary

pfam05210
Location:181 → 278

Sprouty; Sprouty protein (Spry)
NM_011896.3 → NP_036026.1 protein sprouty homolog 1

See identical proteins and their annotated locations for NP_036026.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4, encode the same protein.

Source sequence(s)

AC110508, AK140405, AV377285, BC051977

Consensus CDS

CCDS17322.1

UniProtKB/Swiss-Prot

Q9QXV9

UniProtKB/TrEMBL

Q53ZU1

Related

ENSMUSP00000049292.2, ENSMUST00000038569.8

Conserved Domains (1) summary

pfam05210
Location:181 → 278

Sprouty; Sprouty protein (Spry)