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Sigirr single immunoglobulin and toll-interleukin 1 receptor (TIR) domain [ Mus musculus (house mouse) ]

Gene ID: 24058, updated on 3-Apr-2024

Summary

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Official Symbol
Sigirrprovided by MGI
Official Full Name
single immunoglobulin and toll-interleukin 1 receptor (TIR) domainprovided by MGI
Primary source
MGI:MGI:1344402
See related
Ensembl:ENSMUSG00000025494 AllianceGenome:MGI:1344402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIR8
Summary
Involved in acute-phase response; negative regulation of chemokine production; and negative regulation of cytokine-mediated signaling pathway. Predicted to be located in membrane. Is expressed in genitourinary system. Orthologous to human SIGIRR (single Ig and TIR domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 26.8), placenta adult (RPKM 18.4) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Sigirr in Genome Data Viewer
Location:
7 F5; 7 86.35 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140671088..140680493, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141091175..141100597, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:148258281-148258545 Neighboring gene plakophilin 3 Neighboring gene STARR-positive B cell enhancer ABC_E2255 Neighboring gene anoctamin 9 Neighboring gene STARR-positive B cell enhancer ABC_E451 Neighboring gene predicted gene, 33560

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction. Wang Z, et al. Signal Transduct Target Ther, 2022 Jan 20. PMID 35046386, Free PMC Article
  2. SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin. Giannoudaki E, et al. J Immunol, 2021 Jul 15. PMID 34253575
  3. Single immunoglobulin interleukin-1 receptor-related molecule impairs host defense during pneumonia and sepsis caused by Streptococcus pneumoniae. Blok DC, et al. J Innate Immun, 2014. PMID 24556793, Free PMC Article
  4. Absence of Toll-IL-1 receptor 8/single immunoglobulin IL-1 receptor-related molecule reduces house dust mite-induced allergic airway inflammation in mice. Barry J, et al. Am J Respir Cell Mol Biol, 2013 Sep. PMID 23614768
  5. The toll interleukin-1 receptor (IL-1R) 8/single Ig domain IL-1R-related molecule modulates the renal response to bacterial infection. Leemans JC, et al. Infect Immun, 2012 Nov. PMID 22890991, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation of CD18 stability by SIGIRR-modulated ubiquitination: new insights into the relationship between innate immune response and acute lung injury.
    Title: Regulation of CD18 stability by SIGIRR-modulated ubiquitination: new insights into the relationship between innate immune response and acute lung injury.
  2. Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.
    Title: Interleukin-37 promotes colitis-associated carcinogenesis via SIGIRR-mediated cytotoxic T cells dysfunction.
  3. SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin.
    Title: SIGIRR Negatively Regulates IL-36-Driven Psoriasiform Inflammation and Neutrophil Infiltration in the Skin.
  4. IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8.
    Title: IL-37 exerts therapeutic effects in experimental autoimmune encephalomyelitis through the receptor complex IL-1R5/IL-1R8.
  5. MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr.
    Title: MiR-340 suppresses CCl4-induced acute liver injury through exerting anti-inflammation targeting Sigirr.
  6. Anti-inflammatory mediators ST2 and SIGIRR are induced by diphenyldifluoroketone EF24 in lipopolysaccharide-stimulated dendritic cells.
    Title: Anti-inflammatory mediators ST2 and SIGIRR are induced by diphenyldifluoroketone EF24 in lipopolysaccharide-stimulated dendritic cells.
  7. Single immunoglobulin and Tollinterleukin1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Tolllike receptor4 signaling pathway: A clinical and experimental study.
    Title: Single immunoglobulin and Toll‑interleukin‑1 receptor domain containing molecule protects against severe acute pancreatitis in vitro by negatively regulating the Toll‑like receptor‑4 signaling pathway: A clinical and experimental study.
  8. Stabilization of IL-1R8/Sigirr by USP13 describes a novel anti-inflammatory pathway in diseases that could provide a new strategy to modulate immune activation
    Title: The deubiquitinase USP13 stabilizes the anti-inflammatory receptor IL-1R8/Sigirr to suppress lung inflammation.
  9. SIGIRR is a negative regulator of TLR4 signaling in the developing intestine, and its insufficiency results in native intestinal TLR hyper-responsiveness conducive to the development of severe experimental necrotizing enterocolitis in mice
    Title: Single-Immunoglobulin Interleukin-1-Related Receptor regulates vulnerability to TLR4-mediated necrotizing enterocolitis in a mouse model.
  10. Here the authors show that hyperactivation of the interleukin 1 pathway, through either ablation of the interleukin 1 receptor 8 (IL-1R8, also known as SIGIRR or Tir8) or activation of IL-1R, leads to up-regulation of the mTOR pathway and increased levels of the epigenetic regulator MeCP2, bringing to disruption of dendritic spine morphology, synaptic plasticity and plasticity-related gene expression.
    Title: Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects.
Submit: New GeneRIF Correction See all GeneRIFs (44)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Clone Names

  • MGC102426

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in acute-phase response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
single Ig IL-1-related receptor
Names
single Ig IL-1 receptor related protein
single Ig IL-1R-related molecule
single Ig IL-1R-related protein
single immunoglobulin domain-containing IL1R-related protein
toll/interleukin-1 receptor 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355055.2 → NP_001341984.1  single Ig IL-1-related receptor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109272
    Consensus CDS
    CCDS40179.1
    UniProtKB/Swiss-Prot
    Q52L48, Q9JLZ8
    UniProtKB/TrEMBL
    Q3UKS3, Q3V005
    Related
    ENSMUSP00000147541.2, ENSMUST00000209294.2
    Conserved Domains (2) summary
    pfam01582
    Location:164 → 326
    TIR; TIR domain
    pfam13927
    Location:9 → 101
    Ig_3; Immunoglobulin domain

  2. NM_001427142.1 → NP_001414071.1  single Ig IL-1-related receptor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109272
    UniProtKB/Swiss-Prot
    Q52L48, Q9JLZ8
    UniProtKB/TrEMBL
    Q3UKS3

  3. NM_001427147.1 → NP_001414076.1  single Ig IL-1-related receptor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109272
    UniProtKB/Swiss-Prot
    Q52L48, Q9JLZ8
    UniProtKB/TrEMBL
    Q3UKS3

  4. NM_001427148.1 → NP_001414077.1  single Ig IL-1-related receptor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109272
    UniProtKB/Swiss-Prot
    Q52L48, Q9JLZ8
    UniProtKB/TrEMBL
    Q3UKS3

  5. NM_001427149.1 → NP_001414078.1  single Ig IL-1-related receptor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109272
    UniProtKB/Swiss-Prot
    Q52L48, Q9JLZ8
    UniProtKB/TrEMBL
    Q3UKS3

  6. NM_001427150.1 → NP_001414079.1  single Ig IL-1-related receptor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC109272
    UniProtKB/Swiss-Prot
    Q52L48, Q9JLZ8
    UniProtKB/TrEMBL
    Q3UKS3

  7. NM_001427151.1 → NP_001414080.1  single Ig IL-1-related receptor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC109272

  8. NM_023059.4 → NP_075546.2  single Ig IL-1-related receptor isoform 1

    See identical proteins and their annotated locations for NP_075546.2

    Status: VALIDATED

    Source sequence(s)
    AC109272
    Consensus CDS
    CCDS40179.1
    UniProtKB/Swiss-Prot
    Q52L48, Q9JLZ8
    UniProtKB/TrEMBL
    Q3UKS3, Q3V005
    Related
    ENSMUSP00000095571.3, ENSMUST00000097958.3
    Conserved Domains (2) summary
    pfam01582
    Location:164 → 326
    TIR; TIR domain
    pfam13927
    Location:9 → 101
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140671088..140680493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536175.5 → XP_006536238.2  single Ig IL-1-related receptor isoform X1

    UniProtKB/TrEMBL
    Q3V005
    Conserved Domains (2) summary
    pfam01582
    Location:169 → 331
    TIR; TIR domain
    pfam13927
    Location:14 → 106
    Ig_3; Immunoglobulin domain

  2. XM_011249842.1 → XP_011248144.1  single Ig IL-1-related receptor isoform X3

    Conserved Domains (1) summary
    pfam01582
    Location:83 → 245
    TIR; TIR domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLZ8.2 GenPept UniProtKB/Swiss-Prot:Q9JLZ8

Gene LinkOut

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