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Sh3yl1 Sh3 domain YSC-like 1 [ Mus musculus (house mouse) ]

Gene ID: 24057, updated on 5-Mar-2024

Summary

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Official Symbol
Sh3yl1provided by MGI
Official Full Name
Sh3 domain YSC-like 1provided by MGI
Primary source
MGI:MGI:1346118
See related
Ensembl:ENSMUSG00000020669 AllianceGenome:MGI:1346118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ray; YSC84
Summary
Predicted to enable phosphatase binding activity and phosphatidylinositol binding activity. Acts upstream of or within phosphatidylinositol biosynthetic process and regulation of ruffle assembly. Predicted to be active in ruffle membrane. Orthologous to human SH3YL1 (SH3 and SYLF domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 10.0), liver E14.5 (RPKM 8.4) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
12 A2; 12 13.01 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30961622..31010159)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30911669..30960160)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32320 Neighboring gene ALK and LTK ligand 2 Neighboring gene STARR-seq mESC enhancer starr_31845 Neighboring gene STARR-positive B cell enhancer ABC_E7128 Neighboring gene acid phosphatase 1, soluble Neighboring gene STARR-seq mESC enhancer starr_31846 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene crumbs homolog 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SH3YL1 protein as a novel biomarker for diabetic nephropathy in type 2 diabetes mellitus. Choi GS, et al. Nutr Metab Cardiovasc Dis, 2021 Feb 8. PMID 33223406
  2. LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1. Yoo JY, et al. Cell Rep, 2020 Oct 20. PMID 33086058
  3. A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle. Aoki N, et al. J Invest Dermatol, 2000 May. PMID 10771491
  4. SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. Hasegawa J, et al. J Cell Biol, 2011 May 30. PMID 21624956, Free PMC Article
  5. Gene expression of Sh3d19, a novel adaptor protein with five Src homology 3 domains, in anagen mouse hair follicles. Shimomura Y, et al. J Dermatol Sci, 2003 Feb. PMID 12615363

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1.
    Title: LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1.
  2. SH3YL1 protein as a novel biomarker for diabetic nephropathy in type 2 diabetes mellitus.
    Title: SH3YL1 protein as a novel biomarker for diabetic nephropathy in type 2 diabetes mellitus.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC118159

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within phosphatidylinositol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ruffle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of ruffle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
SH3 domain-containing YSC84-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289480.1 → NP_001276409.1  SH3 domain-containing YSC84-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001276409.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC160932, BB433755, BC058557, BY086053
    Consensus CDS
    CCDS79110.1
    UniProtKB/Swiss-Prot
    O08641
    Related
    ENSMUSP00000106504.3, ENSMUST00000110880.3
    Conserved Domains (2) summary
    cd11525
    Location:11 → 171
    SYLF_SH3YL1_like; The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins
    cd11841
    Location:247 → 300
    SH3_SH3YL1_like; Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein

  2. NM_013709.5 → NP_038737.1  SH3 domain-containing YSC84-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_038737.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AK141199, AV375458
    Consensus CDS
    CCDS25859.1
    UniProtKB/Swiss-Prot
    O08641, Q6P7V3, Q6PDR3
    Related
    ENSMUSP00000020997.9, ENSMUST00000020997.15
    Conserved Domains (2) summary
    cd11525
    Location:11 → 209
    SYLF_SH3YL1_like; The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins
    cd11841
    Location:285 → 338
    SH3_SH3YL1_like; Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein

RNA

  1. NR_110343.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
    Source sequence(s)
    AC160932

  2. NR_186254.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC160932

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    30961622..31010159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003950048.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08641.1 GenPept UniProtKB/Swiss-Prot:O08641

Gene LinkOut

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