U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sh3bp2 SH3-domain binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 24055, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Sh3bp2provided by MGI
Official Full Name
SH3-domain binding protein 2provided by MGI
Primary source
MGI:MGI:1346349
See related
Ensembl:ENSMUSG00000054520 AllianceGenome:MGI:1346349
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
3BP2
Summary
Enables SH3 domain binding activity. Predicted to be involved in signal transduction. Is expressed in brain and spinal cord. Used to study cherubism. Human ortholog(s) of this gene implicated in cherubism. Orthologous to human SH3BP2 (SH3 domain binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 19.5), CNS E14 (RPKM 11.0) and 25 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sh3bp2 in Genome Data Viewer
Location:
5 B2; 5 17.89 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (34683128..34720983)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (34525784..34563639)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene family with sequence homology 193, member A Neighboring gene predicted gene, 57744 Neighboring gene STARR-seq mESC enhancer starr_12839 Neighboring gene STARR-seq mESC enhancer starr_12841 Neighboring gene STARR-positive B cell enhancer ABC_E10314 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34863580-34863766 Neighboring gene TNFAIP3 interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E10315 Neighboring gene STARR-positive B cell enhancer ABC_E6321 Neighboring gene predicted gene, 22847 Neighboring gene STARR-positive B cell enhancer ABC_E3568 Neighboring gene microRNA 7036b Neighboring gene STARR-seq mESC enhancer starr_12845 Neighboring gene adducin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:34979450-34979637 Neighboring gene major facilitator superfamily domain containing 10

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus. Kawahara K, et al. Int J Mol Sci, 2021 Apr 17. PMID 33920631, Free PMC Article
  2. Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8(+) T Cell Expansion and Differentiation. Dimitriou ID, et al. Cell Rep, 2018 Jul 31. PMID 30067970, Free PMC Article
  3. Bone marrow transplantation improves autoinflammation and inflammatory bone loss in SH3BP2 knock-in cherubism mice. Yoshitaka T, et al. Bone, 2015 Feb. PMID 25445458, Free PMC Article
  4. SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model. Mukai T, et al. PLoS One, 2014. PMID 25144740, Free PMC Article
  5. The adaptor 3BP2 is required for early and late events in FcεRI signaling in human mast cells. Ainsua-Enrich E, et al. J Immunol, 2012 Sep 15. PMID 22896635, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Scaffold protein SH3BP2 signalosome is pivotal for immune activation in nephrotic syndrome.
    Title: Scaffold protein SH3BP2 signalosome is pivotal for immune activation in nephrotic syndrome.
  2. Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-kappaB activation.
    Title: Adaptor protein 3BP2 regulates dectin-1-mediated cellular signalling to induce cytokine expression and NF-κB activation.
  3. SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus.
    Title: SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus.
  4. Sh3bp2 gain-of-function mutation ameliorated clinical and immunological phenotypes in lupus-prone mice.
    Title: Sh3bp2 Gain-Of-Function Mutation Ameliorates Lupus Phenotypes in B6.MRL-Fas(lpr) Mice.
  5. Timed regulation of 3bp2 induction is essential for sustaining CD8(+) T cell expansion and differentiation.
    Title: Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8(+) T Cell Expansion and Differentiation.
  6. Bone marrow transplantation also ameliorated the inflammation and bone loss in 10-week-old Sh3bp2(knock in) mice.
    Title: Bone marrow transplantation improves autoinflammation and inflammatory bone loss in SH3BP2 knock-in cherubism mice.
  7. These findings suggest that the SH3BP2 cherubism mutation can cause jawbone destruction by promoting osteoclast formation in response to TNF-alpha expressed in cherubism lesions and that SH3BP2 is a key regulator for TNF-alpha-induced osteoclastogenesis
    Title: SH3BP2 cherubism mutation potentiates TNF-α-induced osteoclastogenesis via NFATc1 and TNF-α-mediated inflammatory bone loss.
  8. 3BP2 was needed for LPS-induced activation of macrophage signaling pathways. Having a single Sh3bp2 Gly418Arg allele and PAMP stimulation had a cooperative effect on macrophage activation and inflammatory responses.
    Title: Cherubism allele heterozygosity amplifies microbe-induced inflammatory responses in murine macrophages.
  9. Phosphorylation of SH3BP2 at Y183 is critical for the TNF-alpha production.
    Title: Enhanced TLR-MYD88 signaling stimulates autoinflammation in SH3BP2 cherubism mice and defines the etiology of cherubism.
  10. Gain-of-function of SH3BP2 augments inflammation and bone loss in the CIA model through increased macrophage activation and osteoclast formation.
    Title: SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
SH3 domain-binding protein 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145858.1 → NP_001139330.1  SH3 domain-binding protein 2 isoform c

    See identical proteins and their annotated locations for NP_001139330.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents use of an alternative promoter and 5' UTR and uses an alternate translation start site, compared to variant 2. The resulting isoform (c) has a shorter and distinct N-terminus, compared to isoform b.
    Source sequence(s)
    AK150265, BC085497
    Consensus CDS
    CCDS51469.1
    UniProtKB/TrEMBL
    Q3U1H0, Q3UD40
    Related
    ENSMUSP00000098874.4, ENSMUST00000101316.10
    Conserved Domains (3) summary
    cd10359
    Location:498 → 598
    SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
    cd13308
    Location:63 → 177
    PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:71 → 173
    PH; PH domain

  2. NM_001145859.1 → NP_001139331.1  SH3 domain-binding protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (b).
    Source sequence(s)
    AK143548, BC085497
    Consensus CDS
    CCDS51470.1
    UniProtKB/TrEMBL
    E9QJU7, Q8C220
    Related
    ENSMUSP00000112554.2, ENSMUST00000118545.8
    Conserved Domains (3) summary
    cd10359
    Location:510 → 610
    SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
    cd13308
    Location:75 → 189
    PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain
    pfam00169
    Location:83 → 185
    PH; PH domain

  3. NM_011893.3 → NP_036023.3  SH3 domain-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_036023.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents use of an alternative promoter and 5' UTR and uses a downstream translation start site, compared to variant 2. The resulting isoform (a) has a shorter N-terminus, compared to isoform b.
    Source sequence(s)
    AK155898, BC085497
    Consensus CDS
    CCDS19215.1
    UniProtKB/TrEMBL
    Q5U3L0, Q8C220
    Related
    ENSMUSP00000070890.8, ENSMUST00000067638.14
    Conserved Domains (2) summary
    cd10359
    Location:454 → 554
    SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
    cd13308
    Location:19 → 133
    PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    34683128..34720983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503954.3 → XP_006504017.1  SH3 domain-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006504017.1

    UniProtKB/TrEMBL
    Q5U3L0, Q8C220
    Conserved Domains (2) summary
    cd10359
    Location:454 → 554
    SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
    cd13308
    Location:19 → 133
    PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain

  2. XM_006503955.1 → XP_006504018.1  SH3 domain-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006504018.1

    UniProtKB/TrEMBL
    Q5U3L0, Q8C220
    Related
    ENSMUSP00000136671.2, ENSMUST00000179943.3
    Conserved Domains (2) summary
    cd10359
    Location:454 → 554
    SH2_SH3BP2; Src homology 2 domain found in c-Abl SH3 domain-binding protein-2 (SH3BP2)
    cd13308
    Location:19 → 133
    PH_3BP2; SH3 domain-binding protein 2 Pleckstrin homology (PH) domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001136088.1: Suppressed sequence

    Description
    NM_001136088.1: This RefSeq was permanently suppressed because it is redundant with NM_001145859.1.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q06649.1 GenPept UniProtKB/Swiss-Prot:Q06649

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous