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Dipk1c divergent protein kinase domain 1C [ Mus musculus (house mouse) ]

Gene ID: 240479, updated on 5-Mar-2024

Summary

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Official Symbol
Dipk1cprovided by MGI
Official Full Name
divergent protein kinase domain 1Cprovided by MGI
Primary source
MGI:MGI:3041188
See related
Ensembl:ENSMUSG00000047992 AllianceGenome:MGI:3041188
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam69c; B230399E16Rik
Summary
Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in forelimb bud; lip; sensory organ; and ventricular layer. Orthologous to human DIPK1C (divergent protein kinase domain 1C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 1.1), frontal lobe adult (RPKM 0.9) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E4; 18 57.53 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84737133..84762820)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84719008..84744695)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45253 Neighboring gene STARR-positive B cell enhancer ABC_E1964 Neighboring gene CNDP dipeptidase 2 Neighboring gene STARR-seq mESC enhancer starr_45255 Neighboring gene WD repeat domain 53 pseudogene Neighboring gene predicted gene, 25005 Neighboring gene predicted gene, 38576 Neighboring gene predicted gene, 17266 Neighboring gene STARR-seq mESC enhancer starr_45257 Neighboring gene STARR-positive B cell enhancer ABC_E8728 Neighboring gene predicted gene 16146 Neighboring gene cytochrome b5 type A (microsomal)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. FAM69C functions as a kinase for eIF2α and promotes stress granule assembly. Wu Z, et al. EMBO Rep, 2023 May 4. PMID 36929224, Free PMC Article
  2. FAM69C, a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia. Mei F, et al. Cell Rep, 2022 Jul 19. PMID 35858575
  3. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FAM69C functions as a kinase for eIF2alpha and promotes stress granule assembly.
    Title: FAM69C functions as a kinase for eIF2α and promotes stress granule assembly.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
divergent protein kinase domain 1C
Names
family with sequence similarity 69, member C
protein FAM69C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408326.1 → NP_001395255.1  divergent protein kinase domain 1C isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC142448
    UniProtKB/Swiss-Prot
    Q8BQT2
    Related
    ENSMUSP00000124603.3, ENSMUST00000161429.3

  2. NM_001408327.1 → NP_001395256.1  divergent protein kinase domain 1C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC142448

  3. NM_001408328.1 → NP_001395257.1  divergent protein kinase domain 1C isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC142448
    Related
    ENSMUSP00000158524.2, ENSMUST00000235504.2

  4. NM_001408329.1 → NP_001395258.1  divergent protein kinase domain 1C isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC142448

  5. NM_001408330.1 → NP_001395259.1  divergent protein kinase domain 1C isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC142448

  6. NM_173770.6 → NP_776131.1  divergent protein kinase domain 1C isoform 3

    See identical proteins and their annotated locations for NP_776131.1

    Status: VALIDATED

    Source sequence(s)
    AC142448
    Consensus CDS
    CCDS29384.1
    UniProtKB/Swiss-Prot
    Q8BQT2
    Related
    ENSMUSP00000057697.2, ENSMUST00000052501.8
    Conserved Domains (1) summary
    pfam12260
    Location:38 → 206
    PIP49_C; Protein-kinase domain of FAM69

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    84737133..84762820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250462.2 → XP_030106322.1  divergent protein kinase domain 1C isoform X3

    Conserved Domains (2) summary
    pfam14875
    Location:1 → 106
    PIP49_N; N-term cysteine-rich ER, FAM69
    cl21453
    Location:122 → 223
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036161145.1 → XP_036017038.1  divergent protein kinase domain 1C isoform X4

    Conserved Domains (1) summary
    pfam12260
    Location:38 → 206
    PIP49_C; Protein-kinase domain of FAM69

  3. XM_036161146.1 → XP_036017039.1  divergent protein kinase domain 1C isoform X4

    Conserved Domains (1) summary
    pfam12260
    Location:38 → 206
    PIP49_C; Protein-kinase domain of FAM69

  4. XM_006526475.3 → XP_006526538.1  divergent protein kinase domain 1C isoform X4

    See identical proteins and their annotated locations for XP_006526538.1

    UniProtKB/Swiss-Prot
    Q8BQT2
    Conserved Domains (1) summary
    pfam12260
    Location:38 → 206
    PIP49_C; Protein-kinase domain of FAM69
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQT2.2 GenPept UniProtKB/Swiss-Prot:Q8BQT2

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