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Zfp407 zinc finger protein 407 [ Mus musculus (house mouse) ]

Gene ID: 240476, updated on 18-Apr-2024

Summary

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Official Symbol
Zfp407provided by MGI
Official Full Name
zinc finger protein 407provided by MGI
Primary source
MGI:MGI:2685179
See related
Ensembl:ENSMUSG00000048410 AllianceGenome:MGI:2685179
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm333; Gm334; Gm948; ZNF407; 6430585N13Rik
Summary
Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in embryo; extraembryonic component; primitive endoderm; and yolk sac. Orthologous to human ZNF407 (zinc finger protein 407). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 1.6), CNS E11.5 (RPKM 1.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E4; 18 57.53 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84225826..84612815, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84207701..84589539, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11664 Neighboring gene predicted gene, 31854 Neighboring gene prostaglandin reductase 3 Neighboring gene STARR-seq mESC enhancer starr_45246 Neighboring gene STARR-seq mESC enhancer starr_45247 Neighboring gene predicted gene, 57824 Neighboring gene STARR-seq mESC enhancer starr_45248 Neighboring gene STARR-positive B cell enhancer mm9_chr18:84524711-84525012 Neighboring gene STARR-positive B cell enhancer mm9_chr18:84554442-84554743 Neighboring gene STARR-seq mESC enhancer starr_45250 Neighboring gene predicted gene, 31909 Neighboring gene STARR-seq mESC enhancer starr_45251 Neighboring gene carnosine dipeptidase 1 Neighboring gene nucleophosmin 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adipocyte-specific deletion of zinc finger protein 407 results in lipodystrophy and insulin resistance in mice. Charrier A, et al. Mol Cell Endocrinol, 2021 Feb 5. PMID 33285243, Free PMC Article
  2. Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. Buchner DA, et al. J Biol Chem, 2015 Mar 6. PMID 25596527, Free PMC Article
  3. Zinc finger protein 407 overexpression upregulates PPAR target gene expression and improves glucose homeostasis in mice. Charrier A, et al. Am J Physiol Endocrinol Metab, 2016 Nov 1. PMID 27624101, Free PMC Article
  4. Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Inagawa M, et al. Mech Dev, 2013 Nov-Dec. PMID 23892084
  5. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adipocyte-specific deletion of zinc finger protein 407 results in lipodystrophy and insulin resistance in mice.
    Title: Adipocyte-specific deletion of zinc finger protein 407 results in lipodystrophy and insulin resistance in mice.
  2. transcriptome analysis revealed that ZFP407 regulates many peroxisome proliferator-activated receptor (PPAR) gamma target genes beyond Glut4.
    Title: Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 407

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033341.2 → NP_001028513.2  zinc finger protein 407

    See identical proteins and their annotated locations for NP_001028513.2

    Status: VALIDATED

    Source sequence(s)
    AC124187, AC126021, AC149591, AC152060
    Consensus CDS
    CCDS50338.1
    UniProtKB/TrEMBL
    G3UVV3
    Related
    ENSMUSP00000118361.2, ENSMUST00000125763.3
    Conserved Domains (4) summary
    COG5048
    Location:1703 → 1758
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:1621 → 1641
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1407 → 1436
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1633 → 1660
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    84225826..84612815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247079.3 → XP_011245381.1  zinc finger protein 407 isoform X1

    Conserved Domains (4) summary
    sd00017
    Location:1621 → 1641
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1407 → 1436
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1633 → 1660
    zf-H2C2_2; Zinc-finger double domain
    pfam13909
    Location:1705 → 1729
    zf-H2C2_5; C2H2-type zinc-finger domain

  2. XM_006526470.5 → XP_006526533.1  zinc finger protein 407 isoform X2

    Conserved Domains (3) summary
    sd00017
    Location:1530 → 1552
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1407 → 1436
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:1548 → 1569
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_877587.3 RNA Sequence

  2. XR_877586.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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