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Adamts19 ADAM metallopeptidase with thrombospondin type 1 motif 19 [ Mus musculus (house mouse) ]

Gene ID: 240322, updated on 21-Apr-2024

Summary

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Official Symbol
Adamts19provided by MGI
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 19provided by MGI
Primary source
MGI:MGI:2442875
See related
Ensembl:ENSMUSG00000053441 AllianceGenome:MGI:2442875
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4831407I23Rik; D230034E10Rik
Summary
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. This gene is predominantly expressed in the ovary with lower levels of expression observed in kidney, heart, skeletal muscle, lung and testis. The encoded preproprotein undergoes proteolytic processing to generate an active protease. [provided by RefSeq, Jul 2016]
Expression
Biased expression in ovary adult (RPKM 2.6), limb E14.5 (RPKM 2.4) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 D3; 18 33.78 cM
Exon count:
28
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (58967819..59186754)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (58835992..59053682)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene isochorismatase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_44704 Neighboring gene predicted gene, 57652 Neighboring gene STARR-seq mESC enhancer starr_44705 Neighboring gene STARR-seq mESC enhancer starr_44706 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene membrane integral NOTCH2 associated receptor 2 Neighboring gene predicted gene, 54033 Neighboring gene chondroitin sulfate synthase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of MFRP and the secreted serine proteases PRSS56 and ADAMTS19 as part of a molecular network involved in ocular growth regulation. Koli S, et al. PLoS Genet, 2021 Mar. PMID 33755662, Free PMC Article
  2. Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave. Menke DB, et al. Dev Biol, 2003 Oct 15. PMID 14550793
  3. Loss of ADAMTS19 causes progressive non-syndromic heart valve disease. Wünnemann F, et al. Nat Genet, 2020 Jan. PMID 31844321, Free PMC Article
  4. Twist1 transcriptional targets in the developing atrio-ventricular canal of the mouse. Vrljicak P, et al. PLoS One, 2012. PMID 22815831, Free PMC Article
  5. Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice. Bouma GJ, et al. Proc Natl Acad Sci U S A, 2007 Sep 18. PMID 17848526, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of MFRP and the secreted serine proteases PRSS56 and ADAMTS19 as part of a molecular network involved in ocular growth regulation.
    Title: Identification of MFRP and the secreted serine proteases PRSS56 and ADAMTS19 as part of a molecular network involved in ocular growth regulation.
  2. Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.
    Title: Loss of ADAMTS19 causes progressive non-syndromic heart valve disease.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 19
Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175506.4 → NP_780715.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 preproprotein

    See identical proteins and their annotated locations for NP_780715.1

    Status: REVIEWED

    Source sequence(s)
    AC132242, AY135183, CJ092717
    Consensus CDS
    CCDS29266.1
    UniProtKB/Swiss-Prot
    P59509
    UniProtKB/TrEMBL
    B2RWW7
    Related
    ENSMUSP00000050535.6, ENSMUST00000052907.7
    Conserved Domains (6) summary
    smart00209
    Location:1091 → 1146
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:328 → 545
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01421
    Location:330 → 545
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:158 → 275
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:793 → 903
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam08686
    Location:1174 → 1199
    PLAC; PLAC (protease and lacunin) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    58967819..59186754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161138.1 → XP_036017031.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X3

    Conserved Domains (2) summary
    pfam05986
    Location:289 → 399
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam19030
    Location:614 → 666
    TSP1_ADAMTS; Thrombospondin type 1 domain

  2. XM_006525919.5 → XP_006525982.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X1

    UniProtKB/TrEMBL
    B2RWW7
    Conserved Domains (5) summary
    smart00209
    Location:1115 → 1170
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:328 → 545
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:161 → 276
    Pep_M12B_propep; Reprolysin family propeptide
    pfam05986
    Location:793 → 903
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam17771
    Location:562 → 629
    ADAM_CR_2; ADAM cysteine-rich domain

  3. XM_036161139.1 → XP_036017032.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X4

    Conserved Domains (2) summary
    pfam05986
    Location:283 → 393
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam19030
    Location:608 → 660
    TSP1_ADAMTS; Thrombospondin type 1 domain

  4. XM_030250458.2 → XP_030106318.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X6

    Conserved Domains (3) summary
    cd04273
    Location:328 → 545
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:161 → 276
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:562 → 621
    ADAM_CR_2; ADAM cysteine-rich domain

  5. XM_011246927.4 → XP_011245229.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X5

    Conserved Domains (3) summary
    cd04273
    Location:328 → 545
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam01562
    Location:161 → 276
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:562 → 587
    ADAM_CR_2; ADAM cysteine-rich domain

  6. XM_011246926.3 → XP_011245228.1  A disintegrin and metalloproteinase with thrombospondin motifs 19 isoform X2

    Conserved Domains (4) summary
    smart00209
    Location:681 → 736
    TSP1; Thrombospondin type 1 repeats
    pfam05986
    Location:359 → 469
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam17771
    Location:128 → 195
    ADAM_CR_2; ADAM cysteine-rich domain
    cl00064
    Location:9 → 111
    ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...

RNA

  1. XR_004939850.1 RNA Sequence

  2. XR_003952519.2 RNA Sequence

  3. XR_004939852.1 RNA Sequence

  4. XR_003952520.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P59509.1 GenPept UniProtKB/Swiss-Prot:P59509

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