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Thada thyroid adenoma associated [ Mus musculus (house mouse) ]

Gene ID: 240174, updated on 11-Apr-2024

Summary

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Official Symbol
Thadaprovided by MGI
Official Full Name
thyroid adenoma associatedprovided by MGI
Primary source
MGI:MGI:3039623
See related
Ensembl:ENSMUSG00000024251 AllianceGenome:MGI:3039623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GITA; 6530405K19; A930021O22
Summary
Predicted to be involved in lipid homeostasis; negative regulation of endoplasmic reticulum calcium ion concentration; and tRNA methylation. Is expressed in several structures, including cartilage; male reproductive gland or organ; nervous system; parathyroid gland; and trachea. Orthologous to human THADA (THADA armadillo repeat containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 2.9), thymus adult (RPKM 2.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E4; 17 55.02 cM
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (84497484..84773674, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (84190056..84466246, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:84580066-84580358 Neighboring gene STARR-positive B cell enhancer ABC_E11651 Neighboring gene VISTA enhancer mm1108 Neighboring gene STARR-positive B cell enhancer mm9_chr17:84587213-84587514 Neighboring gene predicted gene, 41640 Neighboring gene zinc finger protein 36, C3H type-like 2 Neighboring gene predicted gene, 36279 Neighboring gene predicted gene, 24492 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:84729964-84730153 Neighboring gene STARR-seq mESC enhancer starr_43435 Neighboring gene VISTA enhancer mm1109 Neighboring gene predicted gene, 24722 Neighboring gene STARR-positive B cell enhancer ABC_E7562 Neighboring gene STARR-positive B cell enhancer ABC_E5638 Neighboring gene STARR-seq mESC enhancer starr_43440 Neighboring gene predicted gene, 41642 Neighboring gene RIKEN cDNA 4930500A05 gene Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass. Zhang Y, et al. Nat Commun, 2023 Feb 23. PMID 36823211, Free PMC Article
  2. Thada Is Dispensable for Female Fertility in Mice. Han S, et al. Front Endocrinol (Lausanne), 2022. PMID 35480478, Free PMC Article
  3. A domain of the thyroid adenoma associated gene (THADA) conserved in vertebrates becomes destroyed by chromosomal rearrangements observed in thyroid adenomas. Drieschner N, et al. Gene, 2007 Nov 15. PMID 17889454
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic beta-cell function and preserving beta-cell mass.
    Title: THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass.
  2. Thada Is Dispensable for Female Fertility in Mice.
    Title: Thada Is Dispensable for Female Fertility in Mice.
  3. A domain of Thada conserved in vertebrates becomes destroyed by chromosomal rerrangements observed in thyroid adenomas.
    Title: A domain of the thyroid adenoma associated gene (THADA) conserved in vertebrates becomes destroyed by chromosomal rearrangements observed in thyroid adenomas.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of lipid homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endoplasmic reticulum calcium ion concentration ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation ISO
Inferred from Sequence Orthology
more info
  
involved_in tRNA nucleoside ribose methylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tRNA (32-2'-O)-methyltransferase regulator THADA
Names
thyroid adenoma-associated protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426238.1 → NP_001413167.1  tRNA (32-2'-O)-methyltransferase regulator THADA

    Status: VALIDATED

    Source sequence(s)
    AC126694, AC132455, AC139329
    UniProtKB/Swiss-Prot
    A8C756, Q3TDR4, Q3U2L1, Q69ZA8, Q7TPV7, Q8C8S7

  2. NM_183021.3 → NP_898842.2  tRNA (32-2'-O)-methyltransferase regulator THADA

    See identical proteins and their annotated locations for NP_898842.2

    Status: VALIDATED

    Source sequence(s)
    AC132455, AK044550, EF222207
    Consensus CDS
    CCDS50198.1
    UniProtKB/Swiss-Prot
    A8C756, Q3TDR4, Q3U2L1, Q69ZA8, Q7TPV7, Q8C8S7
    Related
    ENSMUSP00000041701.9, ENSMUST00000047524.10
    Conserved Domains (1) summary
    pfam10350
    Location:953 → 1239
    DUF2428; Putative death-receptor fusion protein (DUF2428)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    84497484..84773674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524278.5 → XP_006524341.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X2

    Conserved Domains (1) summary
    pfam10350
    Location:600 → 886
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  2. XM_006524276.5 → XP_006524339.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X1

    See identical proteins and their annotated locations for XP_006524339.1

    UniProtKB/Swiss-Prot
    A8C756, Q3TDR4, Q3U2L1, Q69ZA8, Q7TPV7, Q8C8S7
    Conserved Domains (1) summary
    pfam10350
    Location:953 → 1239
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  3. XM_036160607.1 → XP_036016500.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X2

    Conserved Domains (1) summary
    pfam10350
    Location:600 → 886
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  4. XM_030249803.2 → XP_030105663.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X3

    Conserved Domains (1) summary
    pfam10350
    Location:953 → 1239
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  5. XM_036160608.1 → XP_036016501.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X4

    Conserved Domains (1) summary
    pfam10350
    Location:953 → 1239
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  6. XM_030249804.1 → XP_030105664.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X5

    Conserved Domains (1) summary
    pfam10350
    Location:953 → 1239
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  7. XM_030249805.1 → XP_030105665.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X6

    Conserved Domains (1) summary
    cl19897
    Location:953 → 1080
    DUF2428; Putative death-receptor fusion protein (DUF2428)

  8. XM_036160609.1 → XP_036016502.1  tRNA (32-2'-O)-methyltransferase regulator THADA isoform X7

    Conserved Domains (1) summary
    cl19897
    Location:953 → 1080
    DUF2428; Putative death-receptor fusion protein (DUF2428)

RNA

  1. XR_003952120.1 RNA Sequence

  2. XR_003952121.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177826.2: Suppressed sequence

    Description
    NM_177826.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8C756.1 GenPept UniProtKB/Swiss-Prot:A8C756

Gene LinkOut

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