Rgs7 regulator of G protein signaling 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs7provided by MGI
Official Full Name: regulator of G protein signaling 7provided by MGI
Primary source: MGI:MGI:1346089
See related: Ensembl:ENSMUSG00000026527 AllianceGenome:MGI:1346089
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable G-protein alpha-subunit binding activity; G-protein beta-subunit binding activity; and GTPase activator activity. Involved in regulation of postsynaptic membrane potential. Acts upstream of or within G protein-coupled receptor signaling pathway and regulation of G protein-coupled receptor signaling pathway. Located in several cellular components, including dendrite terminus; glutamatergic synapse; and nucleus. Is active in postsynaptic membrane and presynapse. Is expressed in bone; foot mesenchyme; nervous system; pelvic girdle skeleton; and sensory organ. Orthologous to human RGS7 (regulator of G protein signaling 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 16.1), frontal lobe adult (RPKM 12.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 81.11 cM

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (174886642..175320287, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (175059076..175492862, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity.
Title: A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity.
Striatal RGS7 Regulates Depression-Related Behaviors and Stress-Induced Reinstatement of Cocaine Conditioned Place Preference.
Title: Striatal RGS7 Regulates Depression-Related Behaviors and Stress-Induced Reinstatement of Cocaine Conditioned Place Preference.
Deletion of GPR158 or RGS7 enhanced excitability of layer 2/3 PFC neurons and prevented the impact of stress.
Title: The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex.
Stimulation of the ERK pathway in Gnb5(-/-) cells by epidermal growth factor restored M3R-stimulated insulin release to near normal levels. Identification of the novel role of Gbeta5-R7 in insulin secretion may lead to a new therapeutic approach for improving pancreatic beta-cell function
Title: Regulator of G-protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion.
This study identifies RGS7 as a novel regulator of Mu Opioid Receptor signaling by dissecting its circuit specific actions and pinpointing its role in regulating morphine reward by controlling the activity of nucleus accumbens neurons.
Title: Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum.
R7-binding protein had a strong inhibitory effect on homo-oligomerization of RGS7.
Title: Regulator of G Protein Signaling 7 (RGS7) Can Exist in a Homo-oligomeric Form That Is Regulated by Gαo and R7-binding Protein.
Association with the plasma membrane is sufficient for potentiating catalytic activity of RGS7 and RGS9-2 proteins.
Title: Association with the Plasma Membrane Is Sufficient for Potentiating Catalytic Activity of Regulators of G Protein Signaling (RGS) Proteins of the R7 Subfamily.
results demonstrate a novel role of RGS7 in hippocampal synaptic plasticity and memory formation
Title: RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling.
GPR158 is an essential regulator of RGS7 in the native nervous system with a critical role in controlling its expression, membrane localization, and catalytic activity
Title: Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the Brain.
Expression of the Gbeta5/R7-RGS protein complex in pituitary and pancreatic islet cells.
Title: Expression of the Gβ5/R7-RGS protein complex in pituitary and pancreatic islet cells.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548463

RH131359 (e-PCR)
- UniSTS:214642

Rgs7 (e-PCR), detects polymorphism
- UniSTS:233944

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	ISO Inferred from Sequence Orthology more info
enables G-protein beta-subunit binding	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell tip	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: regulator of G-protein signaling 7

Names: Regulator of G-protein signaling 7 (RGS7)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199003.1 → NP_001185932.1 regulator of G-protein signaling 7 isoform 2

See identical proteins and their annotated locations for NP_001185932.1

Status: VALIDATED

Source sequence(s)

AI844954, BC051133, CJ060456

Consensus CDS

CCDS78755.1

UniProtKB/TrEMBL

Q80XD3

Related

ENSMUSP00000142180.2, ENSMUST00000194555.6

Conserved Domains (3) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
NM_001347195.1 → NP_001334124.1 regulator of G-protein signaling 7 isoform 3

Status: VALIDATED

Source sequence(s)

AC102499, AC113050, AC117693, AC117734, AC159973

Consensus CDS

CCDS83644.1

UniProtKB/TrEMBL

A0A0A6YW36

Related

ENSMUSP00000141380.2, ENSMUST00000195324.6

Conserved Domains (3) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
NM_001357129.1 → NP_001344058.1 regulator of G-protein signaling 7 isoform 4

Status: VALIDATED

Source sequence(s)

AC102499, AC113050, AC117693, AC117734, AC159973

Conserved Domains (3) summary

smart00224
Location:203 → 263

GGL; G protein gamma subunit-like motifs

cd08738
Location:273 → 393

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 76

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
NM_011880.3 → NP_036010.2 regulator of G-protein signaling 7 isoform 1

See identical proteins and their annotated locations for NP_036010.2

Status: VALIDATED

Source sequence(s)

AI844954, BC051133, CJ060511

Consensus CDS

CCDS15546.1

UniProtKB/Swiss-Prot

E9QLB9, O54829

Related

ENSMUSP00000142278.2, ENSMUST00000192227.6

Conserved Domains (3) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

174886642..175320287 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006496828.5 → XP_006496891.1 regulator of G-protein signaling 7 isoform X1

See identical proteins and their annotated locations for XP_006496891.1

Conserved Domains (4) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:113 → 214

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_017320465.3 → XP_017175954.1 regulator of G-protein signaling 7 isoform X8

Conserved Domains (4) summary

smart00224
Location:239 → 299

GGL; G protein gamma subunit-like motifs

cd08738
Location:309 → 429

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 99

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:96 → 197

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_006496830.5 → XP_006496893.1 regulator of G-protein signaling 7 isoform X3

Conserved Domains (4) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:113 → 214

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_011238808.4 → XP_011237110.1 regulator of G-protein signaling 7 isoform X2

Conserved Domains (4) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:113 → 214

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_036164663.1 → XP_036020556.1 regulator of G-protein signaling 7 isoform X6

Conserved Domains (4) summary

smart00224
Location:239 → 299

GGL; G protein gamma subunit-like motifs

cd08738
Location:309 → 429

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 99

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:96 → 197

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_017320468.3 → XP_017175957.1 regulator of G-protein signaling 7 isoform X12

Conserved Domains (4) summary

smart00224
Location:203 → 263

GGL; G protein gamma subunit-like motifs

cd08738
Location:273 → 393

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 76

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:74 → 161

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_030253948.2 → XP_030109808.1 regulator of G-protein signaling 7 isoform X5

Conserved Domains (4) summary

smart00224
Location:239 → 299

GGL; G protein gamma subunit-like motifs

cd08738
Location:309 → 429

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 99

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:96 → 197

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_011238809.4 → XP_011237111.1 regulator of G-protein signaling 7 isoform X10

Conserved Domains (4) summary

smart00224
Location:203 → 263

GGL; G protein gamma subunit-like motifs

cd08738
Location:273 → 393

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 76

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:74 → 161

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_036164664.1 → XP_036020557.1 regulator of G-protein signaling 7 isoform X10

Conserved Domains (4) summary

smart00224
Location:203 → 263

GGL; G protein gamma subunit-like motifs

cd08738
Location:273 → 393

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 76

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:74 → 161

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_030253949.2 → XP_030109809.1 regulator of G-protein signaling 7 isoform X7

Conserved Domains (4) summary

smart00224
Location:239 → 299

GGL; G protein gamma subunit-like motifs

cd08738
Location:309 → 429

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 99

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:96 → 197

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_006496831.5 → XP_006496894.1 regulator of G-protein signaling 7 isoform X4

Conserved Domains (4) summary

smart00224
Location:239 → 299

GGL; G protein gamma subunit-like motifs

cd08738
Location:309 → 429

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 99

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:96 → 197

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_006496834.5 → XP_006496897.1 regulator of G-protein signaling 7 isoform X9

Conserved Domains (4) summary

smart00224
Location:203 → 263

GGL; G protein gamma subunit-like motifs

cd08738
Location:273 → 393

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 76

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:74 → 161

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_036164662.1 → XP_036020555.1 regulator of G-protein signaling 7 isoform X4

Conserved Domains (4) summary

smart00224
Location:239 → 299

GGL; G protein gamma subunit-like motifs

cd08738
Location:309 → 429

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 99

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:96 → 197

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_006496829.5 → XP_006496892.1 regulator of G-protein signaling 7 isoform X1

See identical proteins and their annotated locations for XP_006496892.1

Conserved Domains (4) summary

smart00224
Location:256 → 316

GGL; G protein gamma subunit-like motifs

cd08738
Location:326 → 446

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:29 → 116

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:113 → 214

RGS_DHEX; Regulator of G-protein signalling DHEX domain
XM_036164665.1 → XP_036020558.1 regulator of G-protein signaling 7 isoform X11

Conserved Domains (4) summary

smart00224
Location:181 → 241

GGL; G protein gamma subunit-like motifs

cd08738
Location:251 → 371

RGS_RGS7; Regulator of G protein signaling (RGS) domain found in the RGS7 protein

cd04450
Location:2 → 41

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...

pfam18148
Location:38 → 139

RGS_DHEX; Regulator of G-protein signalling DHEX domain