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Morc2b microrchidia 2B [ Mus musculus (house mouse) ]

Gene ID: 240069, updated on 8-Feb-2024

Summary

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Official Symbol
Morc2bprovided by MGI
Official Full Name
microrchidia 2Bprovided by MGI
Primary source
MGI:MGI:3045293
See related
Ensembl:ENSMUSG00000048602 AllianceGenome:MGI:3045293
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tce6; 4932411A10Rik
Summary
Predicted to enable several functions, including ATP binding activity; metal ion binding activity; and protein homodimerization activity. Involved in double-strand break repair involved in meiotic recombination; gamete generation; and homologous chromosome pairing at meiosis. Located in nucleus. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2Z. Orthologous to human MORC2 (MORC family CW-type zinc finger 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 11.0) See more
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Genomic context

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See Morc2b in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33354562..33369473, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33135588..33150499, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42403 Neighboring gene PHD finger protein 8 like Neighboring gene STARR-positive B cell enhancer ABC_E4206 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33226471-33226658 Neighboring gene zinc finger protein 563 Neighboring gene STARR-seq mESC enhancer starr_42404 Neighboring gene predicted gene, 52288 Neighboring gene predicted gene, 21062 Neighboring gene olfactory receptor family 10 subfamily H member 1B Neighboring gene olfactory receptor family 10 subfamily H member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A histone H3 methyltransferase controls epigenetic events required for meiotic prophase. Hayashi K, et al. Nature, 2005 Nov 17. PMID 16292313
  2. MORC2B is essential for meiotic progression and fertility. Shi B, et al. PLoS Genet, 2018 Jan. PMID 29329290, Free PMC Article
  3. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP hydrolysis activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair involved in meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gamete generation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATPase MORC2B
Names
MORC family CW-type zinc finger protein 2B
Morc-like protein
NP_001347132.1
NP_808387.2
XP_006524320.1
XP_006524321.1
XP_011244746.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360203.1 → NP_001347132.1  ATPase MORC2B

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT033756
    Consensus CDS
    CCDS37561.1
    UniProtKB/Swiss-Prot
    B8JK02, Q8C5W4, Q8CG24
    UniProtKB/TrEMBL
    Q0VAW0
    Conserved Domains (3) summary
    cd16931
    Location:18 → 135
    HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
    pfam07496
    Location:495 → 540
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:238 → 451
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

  2. NM_177719.4 → NP_808387.2  ATPase MORC2B

    See identical proteins and their annotated locations for NP_808387.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK077016, CT033756
    Consensus CDS
    CCDS37561.1
    UniProtKB/Swiss-Prot
    B8JK02, Q8C5W4, Q8CG24
    UniProtKB/TrEMBL
    Q0VAW0
    Related
    ENSMUSP00000056879.8, ENSMUST00000053896.8
    Conserved Domains (3) summary
    cd16931
    Location:18 → 135
    HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
    pfam07496
    Location:495 → 540
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:238 → 451
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    33354562..33369473 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246444.1 → XP_011244746.1  ATPase MORC2B isoform X1

    See identical proteins and their annotated locations for XP_011244746.1

    UniProtKB/Swiss-Prot
    B8JK02, Q8C5W4, Q8CG24
    UniProtKB/TrEMBL
    Q0VAW0
    Conserved Domains (3) summary
    cd16931
    Location:18 → 135
    HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
    pfam07496
    Location:495 → 540
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:238 → 451
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

  2. XM_006524258.4 → XP_006524321.1  ATPase MORC2B isoform X1

    See identical proteins and their annotated locations for XP_006524321.1

    UniProtKB/Swiss-Prot
    B8JK02, Q8C5W4, Q8CG24
    UniProtKB/TrEMBL
    Q0VAW0
    Conserved Domains (3) summary
    cd16931
    Location:18 → 135
    HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
    pfam07496
    Location:495 → 540
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:238 → 451
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like

  3. XM_006524257.4 → XP_006524320.1  ATPase MORC2B isoform X1

    See identical proteins and their annotated locations for XP_006524320.1

    UniProtKB/Swiss-Prot
    B8JK02, Q8C5W4, Q8CG24
    UniProtKB/TrEMBL
    Q0VAW0
    Conserved Domains (3) summary
    cd16931
    Location:18 → 135
    HATPase_MORC-like; Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains
    pfam07496
    Location:495 → 540
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:238 → 451
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C5W4.2 GenPept UniProtKB/Swiss-Prot:Q8C5W4

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