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Cpne5 copine V [ Mus musculus (house mouse) ]

Gene ID: 240058, updated on 21-Apr-2024

Summary

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Official Symbol
Cpne5provided by MGI
Official Full Name
copine Vprovided by MGI
Primary source
MGI:MGI:2385908
See related
Ensembl:ENSMUSG00000024008 AllianceGenome:MGI:2385908
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A830083G22Rik
Summary
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encodes a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. [provided by RefSeq, Jul 2008]
Expression
Broad expression in frontal lobe adult (RPKM 12.0), genital fat pad adult (RPKM 10.0) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 A3.3; 17 15.14 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (29375495..29456764, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (29156521..29237790, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RAB44, member RAS oncogene family Neighboring gene STARR-seq mESC enhancer starr_42259 Neighboring gene ribosomal protein L35A, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_42262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:29301422-29301531 Neighboring gene somatostatin receptor 4 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8663 Neighboring gene STARR-positive B cell enhancer ABC_E10943 Neighboring gene STARR-seq mESC enhancer starr_42268 Neighboring gene predicted gene, 41557 Neighboring gene STARR-positive B cell enhancer ABC_E7507 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cpne5 is Involved in Regulating Rodent Anxiety Level. Ding XF, et al. CNS Neurosci Ther, 2017 Mar. PMID 28168849, Free PMC Article
  2. IL-33, a potent inducer of adaptive immunity to intestinal nematodes. Humphreys NE, et al. J Immunol, 2008 Feb 15. PMID 18250453
  3. Localization and cellular distribution of CPNE5 in embryonic mouse brain. Ding X, et al. Brain Res, 2008 Aug 11. PMID 18614158
  4. Transcriptomic Profiling of the Developing Cardiac Conduction System at Single-Cell Resolution. Goodyer WR, et al. Circ Res, 2019 Aug 2. PMID 31284824, Free PMC Article
  5. In vivo visualization and molecular targeting of the cardiac conduction system. Goodyer WR, et al. J Clin Invest, 2022 Oct 17. PMID 35951416, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC47475

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
copine-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360239.1 → NP_001347168.1  copine-5 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC162182, AC167363
    Conserved Domains (3) summary
    cd04047
    Location:194 → 305
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:23 → 137
    C2A_Copine; C2 domain first repeat in Copine
    cd01459
    Location:315 → 571
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

  2. NM_153166.2 → NP_694806.1  copine-5 isoform 2

    See identical proteins and their annotated locations for NP_694806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2 which is shorter, compared to isoform 1.
    Source sequence(s)
    AC162182, AC167363, AK044042
    Consensus CDS
    CCDS28592.1
    UniProtKB/Swiss-Prot
    Q8JZW4
    Related
    ENSMUSP00000024805.8, ENSMUST00000024805.15
    Conserved Domains (3) summary
    cd04047
    Location:177 → 288
    C2B_Copine; C2 domain second repeat in Copine
    cd04048
    Location:23 → 137
    C2A_Copine; C2 domain first repeat in Copine
    cd01459
    Location:298 → 554
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    29375495..29456764 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160602.1 → XP_036016495.1  copine-5 isoform X1

    Conserved Domains (2) summary
    cd04047
    Location:29 → 140
    C2B_Copine; C2 domain second repeat in Copine
    cd01459
    Location:150 → 406
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

  2. XM_006524251.1 → XP_006524314.1  copine-5 isoform X2

    Conserved Domains (2) summary
    cd04047
    Location:46 → 157
    C2B_Copine; C2 domain second repeat in Copine
    cd01459
    Location:167 → 423
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

  3. XM_017317469.3 → XP_017172958.1  copine-5 isoform X3

    Conserved Domains (1) summary
    cd01459
    Location:2 → 262
    vWA_copine_like; VWA Copine: Copines are phospholipid-binding proteins originally identified in paramecium. They are found in human and orthologues have been found in C. elegans and Arabidopsis Thaliana. None have been found in D. Melanogaster or S. Cereviciae. ...

  4. XM_017317468.3 → XP_017172957.1  copine-5 isoform X4

    Related
    ENSMUST00000126993.8
    Conserved Domains (1) summary
    pfam07002
    Location:1 → 213
    Copine
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8JZW4.1 GenPept UniProtKB/Swiss-Prot:Q8JZW4

Gene LinkOut

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