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Syngap1 synaptic Ras GTPase activating protein 1 homolog (rat) [ Mus musculus (house mouse) ]

Gene ID: 240057, updated on 9-Dec-2024

Summary

Official Symbol
Syngap1provided by MGI
Official Full Name
synaptic Ras GTPase activating protein 1 homolog (rat)provided by MGI
Primary source
MGI:MGI:3039785
See related
Ensembl:ENSMUSG00000067629 AllianceGenome:MGI:3039785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm1963; Syngap
Summary
This gene encodes a Ras GTPase activating protein that is a member of the N-methyl-D-aspartate receptor complex. The N-terminal domain of the protein contains a Ras-GAP domain, a pleckstrin homology domain, and a C2 domain that may be involved in binding of calcium and phospholipids. The C-terminal domain consists of a ten histidine repeat region, serine and tyrosine phosphorylation sites, and a T/SXV motif required for postsynaptic scaffold protein interaction. The encoded protein negatively regulates Ras, Rap and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor trafficking to the postsynaptic membrane to regulate synaptic plasticity and neuronal homeostasis. Homozygous null mutations result in early post-embryonic lethality, while heterozygous mutant mice display a variety of phenotypes that include learning and memory defects, hyperactivity, and audiogenic seizures. [provided by RefSeq, Nov 2016]
Expression
Broad expression in frontal lobe adult (RPKM 23.1), cortex adult (RPKM 20.3) and 18 other tissues See more
Orthologs
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Genomic context

See Syngap1 in Genome Data Viewer
Location:
17 A3.3; 17 13.6 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27160186..27191408)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26941212..26972434)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E487 Neighboring gene microRNA 6968 Neighboring gene PHD finger protein 1 Neighboring gene cutA divalent cation tolerance homolog Neighboring gene microRNA 3083b Neighboring gene microRNA 3083 Neighboring gene STARR-positive B cell enhancer ABC_E7502 Neighboring gene zinc finger and BTB domain containing 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27137073-27137182 Neighboring gene STARR-positive B cell enhancer ABC_E11633 Neighboring gene gametogenetin binding protein 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27164461-27164644 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:27165231-27165340 Neighboring gene BCL2-antagonist/killer 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity PubMed 
enables GTPase activator activity  
enables SH3 domain binding  
enables protein binding PubMed 
enables protein kinase binding  
Process Evidence Code Pubs
acts_upstream_of_or_within Ras protein signal transduction PubMed 
acts_upstream_of axonogenesis PubMed 
acts_upstream_of_or_within dendrite development PubMed 
involved_in maintenance of postsynaptic specialization structure PubMed 
involved_in maintenance of postsynaptic specialization structure PubMed 
involved_in modulation of chemical synaptic transmission PubMed 
involved_in modulation of chemical synaptic transmission PubMed 
involved_in negative regulation of Ras protein signal transduction  
involved_in negative regulation of Ras protein signal transduction  
acts_upstream_of_or_within negative regulation of axonogenesis PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process PubMed 
acts_upstream_of neuron apoptotic process PubMed 
acts_upstream_of_or_within pattern specification process PubMed 
acts_upstream_of_or_within receptor clustering PubMed 
acts_upstream_of_or_within regulation of MAPK cascade PubMed 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity PubMed 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity PubMed 
acts_upstream_of_or_within regulation of synapse structure or activity PubMed 
involved_in regulation of synaptic plasticity  
involved_in regulation of synaptic plasticity  
acts_upstream_of_or_within visual learning PubMed 
Component Evidence Code Pubs
located_in dendritic shaft PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
located_in membrane PubMed 
located_in plasma membrane  
located_in postsynaptic density PubMed 
is_active_in postsynaptic density, intracellular component  
located_in synapse  

General protein information

Preferred Names
ras/Rap GTPase-activating protein SynGAP
Names
neuronal RasGAP
ras GTPase-activating protein SynGAP
synaptic Ras GTPase-activating protein 1
synaptic Ras-GAP 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281491.2NP_001268420.1  ras/Rap GTPase-activating protein SynGAP isoform 1

    See identical proteins and their annotated locations for NP_001268420.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC144621
    Consensus CDS
    CCDS59625.1
    UniProtKB/Swiss-Prot
    F6SEU4
    UniProtKB/TrEMBL
    A0A2S1B6B8
    Related
    ENSMUSP00000141686.2, ENSMUST00000194598.6
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181307
    DUF3498; Domain of unknown function (DUF3498)
  2. NM_001371033.1NP_001357962.1  ras/Rap GTPase-activating protein SynGAP isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC144621
    UniProtKB/TrEMBL
    A0A2S1B6B8
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181305
    DUF3498; Domain of unknown function (DUF3498)
  3. NM_001371034.1NP_001357963.1  ras/Rap GTPase-activating protein SynGAP isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC144621
    UniProtKB/TrEMBL
    A0A0J9YVH8
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181245
    DUF3498; Domain of unknown function (DUF3498)
  4. NM_001394027.1NP_001380956.1  ras/Rap GTPase-activating protein SynGAP isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC144621
    UniProtKB/TrEMBL
    A0A2S1B6F9
    Related
    ENSMUSP00000080038.5, ENSMUST00000081285.9
    Conserved Domains (4) summary
    cd04013
    Location:166328
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:319642
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:36227
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    TIGR02169
    Location:10841207
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    27160186..27191408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524237.2XP_006524300.1  ras/Rap GTPase-activating protein SynGAP isoform X5

    UniProtKB/TrEMBL
    A0A0J9YUM2
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181278
    DUF3498; Domain of unknown function (DUF3498)
  2. XM_006524245.3XP_006524308.1  ras/Rap GTPase-activating protein SynGAP isoform X14

    See identical proteins and their annotated locations for XP_006524308.1

    UniProtKB/TrEMBL
    A0A0J9YVH8
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181261
    DUF3498; Domain of unknown function (DUF3498)
  3. XM_006524240.2XP_006524303.1  ras/Rap GTPase-activating protein SynGAP isoform X7

    UniProtKB/TrEMBL
    A0A2S1B6B8
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181308
    DUF3498; Domain of unknown function (DUF3498)
  4. XM_030249787.1XP_030105647.1  ras/Rap GTPase-activating protein SynGAP isoform X15

    UniProtKB/TrEMBL
    A0A0J9YVH8
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181259
    DUF3498; Domain of unknown function (DUF3498)
  5. XM_030249784.1XP_030105644.1  ras/Rap GTPase-activating protein SynGAP isoform X9

    UniProtKB/TrEMBL
    A0A2S1B6B8
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181291
    DUF3498; Domain of unknown function (DUF3498)
  6. XM_006524247.2XP_006524310.1  ras/Rap GTPase-activating protein SynGAP isoform X14

    See identical proteins and their annotated locations for XP_006524310.1

    UniProtKB/TrEMBL
    A0A0J9YVH8
    Related
    ENSMUSP00000144666.3, ENSMUST00000201349.6
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181261
    DUF3498; Domain of unknown function (DUF3498)
  7. XM_036160599.1XP_036016492.1  ras/Rap GTPase-activating protein SynGAP isoform X14

    UniProtKB/TrEMBL
    A0A0J9YVH8
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181261
    DUF3498; Domain of unknown function (DUF3498)
  8. XM_006524235.2XP_006524298.1  ras/Rap GTPase-activating protein SynGAP isoform X1

    UniProtKB/TrEMBL
    A0A2R8VHH2
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181292
    DUF3498; Domain of unknown function (DUF3498)
  9. XM_006524243.2XP_006524306.1  ras/Rap GTPase-activating protein SynGAP isoform X12

    UniProtKB/TrEMBL
    J3QQ18
    Related
    ENSMUSP00000141245.3, ENSMUST00000193200.6
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181292
    DUF3498; Domain of unknown function (DUF3498)
  10. XM_006524236.2XP_006524299.1  ras/Rap GTPase-activating protein SynGAP isoform X2

    UniProtKB/TrEMBL
    A0A2R8VHH2
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181290
    DUF3498; Domain of unknown function (DUF3498)
  11. XM_030249783.1XP_030105643.1  ras/Rap GTPase-activating protein SynGAP isoform X3

    UniProtKB/TrEMBL
    A0A0J9YUM2
    Conserved Domains (4) summary
    cd04013
    Location:252414
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:405728
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:122313
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:7181276
    DUF3498; Domain of unknown function (DUF3498)
  12. XM_006524241.3XP_006524304.1  ras/Rap GTPase-activating protein SynGAP isoform X8

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:176338
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:329652
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:46237
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:6421216
    DUF3498; Domain of unknown function (DUF3498)
  13. XM_030249791.1XP_030105651.1  ras/Rap GTPase-activating protein SynGAP isoform X21

    Conserved Domains (2) summary
    pfam12004
    Location:116659
    DUF3498; Domain of unknown function (DUF3498)
    cl02569
    Location:1126
    RasGAP; Ras GTPase Activating Domain
  14. XM_036160597.1XP_036016490.1  ras/Rap GTPase-activating protein SynGAP isoform X4

    UniProtKB/TrEMBL
    A0A0A6YVS6
    Conserved Domains (4) summary
    cd04013
    Location:224386
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:377700
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:94285
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:6901264
    DUF3498; Domain of unknown function (DUF3498)
  15. XM_006524238.5XP_006524301.1  ras/Rap GTPase-activating protein SynGAP isoform X4

    See identical proteins and their annotated locations for XP_006524301.1

    UniProtKB/TrEMBL
    A0A0A6YVS6
    Conserved Domains (4) summary
    cd04013
    Location:224386
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:377700
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:94285
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:6901264
    DUF3498; Domain of unknown function (DUF3498)
  16. XM_030249786.1XP_030105646.1  ras/Rap GTPase-activating protein SynGAP isoform X13

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:135297
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:288611
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:5196
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:6011175
    DUF3498; Domain of unknown function (DUF3498)
  17. XM_006524244.5XP_006524307.1  ras/Rap GTPase-activating protein SynGAP isoform X13

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:135297
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:288611
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:5196
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:6011175
    DUF3498; Domain of unknown function (DUF3498)
  18. XM_036160600.1XP_036016493.1  ras/Rap GTPase-activating protein SynGAP isoform X16

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:135297
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:288611
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:5196
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:6011161
    DUF3498; Domain of unknown function (DUF3498)
  19. XM_006524242.3XP_006524305.1  ras/Rap GTPase-activating protein SynGAP isoform X10

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:166328
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:319642
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:36227
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:6321206
    DUF3498; Domain of unknown function (DUF3498)
  20. XM_030249785.2XP_030105645.1  ras/Rap GTPase-activating protein SynGAP isoform X11

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:166328
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:319642
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:36227
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:6321192
    DUF3498; Domain of unknown function (DUF3498)
  21. XM_036160598.1XP_036016491.1  ras/Rap GTPase-activating protein SynGAP isoform X13

    UniProtKB/TrEMBL
    A0A2S1B6F9
    Conserved Domains (4) summary
    cd04013
    Location:135297
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:288611
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:5196
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:6011175
    DUF3498; Domain of unknown function (DUF3498)
  22. XM_006524239.5XP_006524302.1  ras/Rap GTPase-activating protein SynGAP isoform X6

    UniProtKB/TrEMBL
    A0A2R8VH83
    Conserved Domains (4) summary
    cd04013
    Location:193355
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:346669
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    cd13375
    Location:63254
    PH_SynGAP; Synaptic Ras-GTPase activating protein Pleckstrin homology (PH) domain
    pfam12004
    Location:6591233
    DUF3498; Domain of unknown function (DUF3498)
  23. XM_036160601.1XP_036016494.1  ras/Rap GTPase-activating protein SynGAP isoform X19

    Conserved Domains (2) summary
    pfam12004
    Location:116691
    DUF3498; Domain of unknown function (DUF3498)
    cl02569
    Location:1126
    RasGAP; Ras GTPase Activating Domain
  24. XM_030249790.1XP_030105650.1  ras/Rap GTPase-activating protein SynGAP isoform X20

    Conserved Domains (2) summary
    pfam12004
    Location:116689
    DUF3498; Domain of unknown function (DUF3498)
    cl02569
    Location:1126
    RasGAP; Ras GTPase Activating Domain
  25. XM_006524248.3XP_006524311.1  ras/Rap GTPase-activating protein SynGAP isoform X17

    Conserved Domains (2) summary
    pfam12004
    Location:116690
    DUF3498; Domain of unknown function (DUF3498)
    cl02569
    Location:1126
    RasGAP; Ras GTPase Activating Domain
  26. XM_030249788.2XP_030105648.1  ras/Rap GTPase-activating protein SynGAP isoform X18

    Conserved Domains (2) summary
    pfam12004
    Location:116676
    DUF3498; Domain of unknown function (DUF3498)
    cl02569
    Location:1126
    RasGAP; Ras GTPase Activating Domain

RNA

  1. XR_003952116.1 RNA Sequence

  2. XR_003952115.1 RNA Sequence

  3. XR_385324.4 RNA Sequence

  4. XR_003952117.1 RNA Sequence

  5. XR_004939524.1 RNA Sequence

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