U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp760 zinc finger protein 760 [ Mus musculus (house mouse) ]

Gene ID: 240034, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp760provided by MGI
Official Full Name
zinc finger protein 760provided by MGI
Primary source
MGI:MGI:2679257
See related
Ensembl:ENSMUSG00000067928 AllianceGenome:MGI:2679257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9430018I06
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in genitourinary system. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 6.6), CNS E14 (RPKM 6.2) and 17 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 A3.3; 17 11.4 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21926412..21944616)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21707430..21725636)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 983 Neighboring gene predicted gene, 53991 Neighboring gene STARR-positive B cell enhancer ABC_E1933 Neighboring gene predicted gene 10509 Neighboring gene STARR-seq mESC enhancer starr_42015 Neighboring gene zinc finger protein 229 Neighboring gene zinc finger protein 760 pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  2. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Homology

Clone Names

  • MGC105247

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 760

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008501.3 → NP_001008501.2  zinc finger protein 760 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT009755, MF597758
    Consensus CDS
    CCDS37465.1
    UniProtKB/TrEMBL
    E9QAF5
    Related
    ENSMUSP00000073038.7, ENSMUST00000073312.7
    Conserved Domains (5) summary
    COG5048
    Location:206 → 581
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:568 → 618
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:210 → 230
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 47
    KRAB; KRAB box
    pfam13465
    Location:614 → 639
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001410563.1 → NP_001397492.1  zinc finger protein 760 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT009755, MF597758

  3. NM_001410564.1 → NP_001397493.1  zinc finger protein 760 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT009755, MF597758
    UniProtKB/TrEMBL
    E9QAF5

  4. NM_001410565.1 → NP_001397494.1  zinc finger protein 760 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT009755, MF597758
    UniProtKB/TrEMBL
    E9QAF5

  5. NM_001410566.1 → NP_001397495.1  zinc finger protein 760 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT009755, MF597758

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    21926412..21944616
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249770.1 → XP_030105630.1  zinc finger protein 760 isoform X1

    Conserved Domains (5) summary
    COG5048
    Location:211 → 586
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:573 → 623
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:215 → 235
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box
    pfam13465
    Location:619 → 644
    zf-H2C2_2; Zinc-finger double domain

  2. XM_030249771.1 → XP_030105631.1  zinc finger protein 760 isoform X2

    UniProtKB/TrEMBL
    E9QAF5
    Conserved Domains (5) summary
    COG5048
    Location:206 → 581
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:568 → 618
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:210 → 230
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:7 → 47
    KRAB; KRAB box
    pfam13465
    Location:614 → 639
    zf-H2C2_2; Zinc-finger double domain

  3. XM_030249773.1 → XP_030105633.1  zinc finger protein 760 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:165 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:527 → 577
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:169 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:573 → 598
    zf-H2C2_2; Zinc-finger double domain

  4. XM_036160590.1 → XP_036016483.1  zinc finger protein 760 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:165 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:527 → 577
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:169 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:573 → 598
    zf-H2C2_2; Zinc-finger double domain

  5. XM_030249772.1 → XP_030105632.1  zinc finger protein 760 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:165 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:527 → 577
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:169 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:573 → 598
    zf-H2C2_2; Zinc-finger double domain

  6. XM_036160588.1 → XP_036016481.1  zinc finger protein 760 isoform X1

    Conserved Domains (5) summary
    COG5048
    Location:211 → 586
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:573 → 623
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:215 → 235
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:12 → 52
    KRAB; KRAB box
    pfam13465
    Location:619 → 644
    zf-H2C2_2; Zinc-finger double domain

  7. XM_036160591.1 → XP_036016484.1  zinc finger protein 760 isoform X3

    Conserved Domains (4) summary
    COG5048
    Location:165 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:527 → 577
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:169 → 189
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:573 → 598
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous