Twf2 twinfilin actin binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Twf2provided by MGI
Official Full Name: twinfilin actin binding protein 2provided by MGI
Primary source: MGI:MGI:1346078
See related: Ensembl:ENSMUSG00000023277 AllianceGenome:MGI:1346078
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ptk9l; Ptk9r; A6-related
Summary: Enables actin monomer binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in barbed-end actin filament capping and sequestering of actin monomers. Located in several cellular components, including lamellipodium; myofibril; and stereocilium. Is expressed in several structures, including ear; early embryo; genitourinary system; nervous system; and respiratory system. Orthologous to human TWF2 (twinfilin actin binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in heart adult (RPKM 69.7), thymus adult (RPKM 44.4) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 57.46 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (106080307..106092586)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (106203108..106215387)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Twf2a-controlled actin rearrangements dampen platelet activation responses.
Title: Twinfilin 2a regulates platelet reactivity and turnover in mice.
These data suggest that twinfilin-2a plays a redundant role in cytoskeletal dynamics with the biochemically similar twinfilin-1, which is typically co-expressed in same tissues with twinfilin-2a.
Title: Twinfilin-2a is dispensable for mouse development.
MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear
Title: MyosinVIIa interacts with Twinfilin-2 at the tips of mechanosensory stereocilia in the inner ear.
This study suggested that twinfilin 2 plays a role in the regulation of stereocilia elongation by restricting excessive elongation of the shorter row stereocilia thereby maintaining the mature staircase architecture of cochlear hair bundles.
Title: Twinfilin 2 regulates actin filament lengths in cochlear stereocilia.
like Twf1, mouse Twf2 is a filament barbed-end capping protein, and that two tissue-specific and biochemically distinct isoforms are generated from the Twf2 gene through alternative promoter usage
Title: Two biochemically distinct and tissue-specific twinfilin isoforms are generated from the mouse Twf2 gene by alternative promoter usage.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Chemically induced (ENU) (1)
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW554607 (e-PCR)
- UniSTS:208440

AU014993 (e-PCR)
- UniSTS:208444

Twf2 (e-PCR), detects polymorphism
- UniSTS:507296

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin monomer binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of lamellipodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microvillus length	IC Inferred by Curator more info	PubMed
involved_in sequestering of actin monomers	IBA Inferred from Biological aspect of Ancestor more info
involved_in sequestering of actin monomers	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
is_active_in myofibril	IBA Inferred from Biological aspect of Ancestor more info
located_in myofibril	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: twinfilin-2

Names: PTK9 protein typrotein tyrosine kinase 9-like (A6-related protein); mA6RP; protein tyrosine kinase 9 related protein; protein tyrosine kinase 9-like (A6-related protein); twinfilin, actin-binding protein, homolog 2; twinfilin-1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011876.3 → NP_036006.1 twinfilin-2

See identical proteins and their annotated locations for NP_036006.1

Status: PROVISIONAL

Source sequence(s)

AC164430

Consensus CDS

CCDS23473.1

UniProtKB/Swiss-Prot

Q3TD06, Q3TZG2, Q8BN77, Q9DCK8, Q9Z0P5

Related

ENSMUSP00000024047.6, ENSMUST00000024047.12

Conserved Domains (2) summary

cd11284
Location:176 → 311

ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins

cd11285
Location:4 → 142

ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins