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Liph lipase, member H [ Mus musculus (house mouse) ]

Gene ID: 239759, updated on 5-Mar-2024

Summary

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Official Symbol
Liphprovided by MGI
Official Full Name
lipase, member Hprovided by MGI
Primary source
MGI:MGI:2388029
See related
Ensembl:ENSMUSG00000044626 AllianceGenome:MGI:2388029
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
P3; H06; lpd1; lpd2; Lpdlr; PLA1B; mPA-PLA1; D16Wsu119e; C130037N08Rik
Summary
Predicted to enable heparin binding activity; lipoprotein lipase activity; and phospholipase activity. Predicted to be involved in fatty acid biosynthetic process and triglyceride catabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in extracellular space. Is expressed in anal canal; epidermis; extraembryonic component; genitourinary system; and gut. Human ortholog(s) of this gene implicated in hypotrichosis 7. Orthologous to human LIPH (lipase H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 8.8), large intestine adult (RPKM 8.0) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B1; 16 12.95 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (21772567..21814408, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (21953817..21995658, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 13 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40374 Neighboring gene transmembrane protein 41a Neighboring gene STARR-seq mESC enhancer starr_40375 Neighboring gene STARR-seq mESC enhancer starr_40377 Neighboring gene STARR-seq mESC enhancer starr_40378 Neighboring gene STARR-positive B cell enhancer ABC_E393 Neighboring gene STARR-seq mESC enhancer starr_40381 Neighboring gene SUMO/sentrin specific peptidase 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit A11B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Lipase H, a new member of the triglyceride lipase family synthesized by the intestine. Jin W, et al. Genomics, 2002 Sep. PMID 12213196
  2. Murine phosphatidylserine-specific phospholipase A1 (Ps-pla1) maps to chromosome 16 but is distinct from the lpd (lipid defect) locus. Wen XY, et al. Mamm Genome, 2001 Feb. PMID 11210182
  3. LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling. Inoue A, et al. EMBO J, 2011 Aug 19. PMID 21857648, Free PMC Article
  4. Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans. Wen XY, et al. Hum Mol Genet, 2003 May 15. PMID 12719377
  5. Characterization of lpd (lipid defect): a novel mutation on mouse chromosome 16 associated with a defect in triglyceride metabolism. Wen XY, et al. Hum Mol Genet, 1998 Apr. PMID 9499429

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Associated conditions

Description Tests
lipid defect 1
GeneReviews: Not available

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lipase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lipase member H
Names
lipase H
NP_001077363.1
NP_001276510.1
NP_001276511.1
NP_700453.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083894.1 → NP_001077363.1  lipase member H isoform 1 precursor

    See identical proteins and their annotated locations for NP_001077363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK134352, AK162492, BQ032777, BY118220
    Consensus CDS
    CCDS37296.1
    UniProtKB/Swiss-Prot
    Q3TRT3, Q3TTZ0, Q3UWA2, Q8BXB5, Q8CI45, Q8CIV3
    Related
    ENSMUSP00000062310.7, ENSMUST00000060673.8
    Conserved Domains (1) summary
    cd00707
    Location:41 → 310
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

  2. NM_001289581.1 → NP_001276510.1  lipase member H isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate splice sites in the 5' UTR and coding region compared to variant 1. These differences cause translation initiation at a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK137278, BQ032777, CT030725
    Conserved Domains (1) summary
    cl21494
    Location:1 → 161
    Abhydrolase; alpha/beta hydrolases

  3. NM_001289582.1 → NP_001276511.1  lipase member H isoform 4 precursor

    See identical proteins and their annotated locations for NP_001276511.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK048150, BQ032777, CT030725
    Consensus CDS
    CCDS88903.1
    UniProtKB/Swiss-Prot
    Q8CIV3
    Related
    ENSMUSP00000156378.2, ENSMUST00000231766.2
    Conserved Domains (1) summary
    cd00707
    Location:41 → 308
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

  4. NM_153404.3 → NP_700453.1  lipase member H isoform 2 precursor

    See identical proteins and their annotated locations for NP_700453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BQ032777, CT030725
    Consensus CDS
    CCDS37295.1
    UniProtKB/Swiss-Prot
    Q8CIV3
    Related
    ENSMUSP00000073853.5, ENSMUST00000074230.12
    Conserved Domains (1) summary
    cd00707
    Location:41 → 280
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    21772567..21814408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004939190.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CIV3.2 GenPept UniProtKB/Swiss-Prot:Q8CIV3

Gene LinkOut

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