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Pacsin2 protein kinase C and casein kinase substrate in neurons 2 [ Mus musculus (house mouse) ]

Gene ID: 23970, updated on 11-Apr-2024

Summary

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Official Symbol
Pacsin2provided by MGI
Official Full Name
protein kinase C and casein kinase substrate in neurons 2provided by MGI
Primary source
MGI:MGI:1345153
See related
Ensembl:ENSMUSG00000016664 AllianceGenome:MGI:1345153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SdpII
Summary
Enables cytoskeletal protein binding activity and lipid binding activity. Involved in cell projection morphogenesis; modulation of chemical synaptic transmission; and plasma membrane tubulation. Acts upstream of or within negative regulation of endocytosis. Located in caveola; cell-cell junction; and cytosol. Is extrinsic component of membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; aorta; eye; genitourinary system; and thymus. Orthologous to human PACSIN2 (protein kinase C and casein kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 34.6), kidney adult (RPKM 33.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 E1; 15 39.4 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83259812..83348800, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83375607..83464610, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor GTPase activating protein 3 Neighboring gene RIKEN cDNA 1700001L05 gene Neighboring gene microRNA 12186 Neighboring gene predicted gene, 41368 Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 pseudogene 1 Neighboring gene STARR-positive B cell enhancer ABC_E2449 Neighboring gene predicted gene, 52181 Neighboring gene tubulin tyrosine ligase-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PACSIN proteins in vivo: Roles in development and physiology. Dumont V, et al. Acta Physiol (Oxf), 2022 Mar. PMID 34990060, Free PMC Article
  2. PACSIN2-dependent apical endocytosis regulates the morphology of epithelial microvilli. Postema MM, et al. Mol Biol Cell, 2019 Sep 1. PMID 31390291, Free PMC Article
  3. The cytoplasmic protein Pacsin 2 in kidney development and injury repair. Yao G, et al. Kidney Int, 2013 Mar. PMID 23235565, Free PMC Article
  4. Ultrastructural freeze-fracture immunolabeling identifies plasma membrane-localized syndapin II as a crucial factor in shaping caveolae. Koch D, et al. Histochem Cell Biol, 2012 Aug. PMID 22718246
  5. Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis. Hansen CG, et al. J Cell Sci, 2011 Aug 15. PMID 21807942

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PACSIN2 regulates platelet integrin beta1 hemostatic function.
    Title: PACSIN2 regulates platelet integrin β1 hemostatic function.
  2. PACSIN proteins in vivo: Roles in development and physiology.
    Title: PACSIN proteins in vivo: Roles in development and physiology.
  3. Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes.
    Title: Dynamin 2 and BAR domain protein pacsin 2 cooperatively regulate formation and maturation of podosomes.
  4. Pacsin 2 is necessary for cardiac development and function in mouse embryos.
    Title: Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.
  5. Pacsin 2 contributes to kidney development and repair in a nephron-specific manner.
    Title: The cytoplasmic protein Pacsin 2 in kidney development and injury repair.
  6. syndapin II binds to both flat and curved membranes in vivo and that it plays an important role in caveolar shaping, a role that it shares with PTRF/cavin 1.
    Title: Ultrastructural freeze-fracture immunolabeling identifies plasma membrane-localized syndapin II as a crucial factor in shaping caveolae.
  7. important role in the formation of plasma membrane caveolae
    Title: Pacsin 2 is recruited to caveolae and functions in caveolar biogenesis.
  8. These findings suggest a novel function for PACSIN proteins 1, 2, and 3 in dynamic microtubule nucleation.
    Title: PACSIN proteins bind tubulin and promote microtubule assembly.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytoskeletal protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in caveola assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in caveolin-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in cell projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in plasma membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane tubulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plasma membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to endosome ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in caveola IDA
Inferred from Direct Assay
more info
 PubMed 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in glutamatergic synapse IC
Inferred by Curator
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C and casein kinase substrate in neurons protein 2
Names
Syndapin II
syndapin-2
syndapin-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159509.2 → NP_001152981.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001152981.1

    Status: VALIDATED

    Source sequence(s)
    AC165945, AL583889
    Consensus CDS
    CCDS27701.1
    UniProtKB/Swiss-Prot
    Q9WVE8
    UniProtKB/TrEMBL
    Q3TDA7
    Related
    ENSMUSP00000131504.2, ENSMUST00000171436.8
    Conserved Domains (3) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:429 → 484
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    pfam16601
    Location:348 → 428
    NPF; Rabosyn-5 repeating NPF sequence-motif

  2. NM_001159510.2 → NP_001152982.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001152982.1

    Status: VALIDATED

    Source sequence(s)
    AC165945, AL583889
    Consensus CDS
    CCDS27701.1
    UniProtKB/Swiss-Prot
    Q9WVE8
    UniProtKB/TrEMBL
    Q3TDA7
    Related
    ENSMUSP00000155334.2, ENSMUST00000231184.2
    Conserved Domains (3) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:429 → 484
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    pfam16601
    Location:348 → 428
    NPF; Rabosyn-5 repeating NPF sequence-motif

  3. NM_001358641.2 → NP_001345570.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC165945, AL583889
    Conserved Domains (3) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:431 → 486
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    pfam16601
    Location:342 → 430
    NPF; Rabosyn-5 repeating NPF sequence-motif

  4. NM_001358642.2 → NP_001345571.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC165945, AL583889
    Conserved Domains (2) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:390 → 445
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

  5. NM_001358643.2 → NP_001345572.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC165945, AL583889
    Conserved Domains (2) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:388 → 443
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

  6. NM_001358644.2 → NP_001345573.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC165945, AL583889
    Conserved Domains (2) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:390 → 445
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

  7. NM_001411850.1 → NP_001398779.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC165945, AL583889
    UniProtKB/Swiss-Prot
    Q9WVE8
    UniProtKB/TrEMBL
    Q3TDA7

  8. NM_001411851.1 → NP_001398780.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC165945, AL583889
    UniProtKB/Swiss-Prot
    Q9WVE8
    UniProtKB/TrEMBL
    Q3TDA7

  9. NM_001411852.1 → NP_001398781.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC165945, AL583889

  10. NM_011862.4 → NP_035992.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

    See identical proteins and their annotated locations for NP_035992.1

    Status: VALIDATED

    Source sequence(s)
    AC165945, AL583889
    Consensus CDS
    CCDS27701.1
    UniProtKB/Swiss-Prot
    Q9WVE8
    UniProtKB/TrEMBL
    Q3TDA7
    Related
    ENSMUSP00000130098.2, ENSMUST00000165095.9
    Conserved Domains (3) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:429 → 484
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    pfam16601
    Location:348 → 428
    NPF; Rabosyn-5 repeating NPF sequence-motif

RNA

  1. NR_177947.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC165945, AL583889

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    83259812..83348800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245633.4 → XP_011243935.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011243935.1

    Conserved Domains (3) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:431 → 486
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    pfam16601
    Location:342 → 430
    NPF; Rabosyn-5 repeating NPF sequence-motif

  2. XM_006520981.4 → XP_006521044.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006521044.1

    Conserved Domains (3) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:431 → 486
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    pfam16601
    Location:342 → 430
    NPF; Rabosyn-5 repeating NPF sequence-motif

  3. XM_036159409.1 → XP_036015302.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

    Conserved Domains (3) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:431 → 486
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    pfam16601
    Location:342 → 430
    NPF; Rabosyn-5 repeating NPF sequence-motif

  4. XM_006520980.4 → XP_006521043.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006521043.1

    Conserved Domains (3) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:431 → 486
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    pfam16601
    Location:342 → 430
    NPF; Rabosyn-5 repeating NPF sequence-motif

  5. XM_006520983.5 → XP_006521046.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006521046.1

    Conserved Domains (3) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:431 → 486
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    pfam16601
    Location:342 → 430
    NPF; Rabosyn-5 repeating NPF sequence-motif

  6. XM_006520982.2 → XP_006521045.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006521045.1

    Conserved Domains (3) summary
    cd07679
    Location:18 → 275
    F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
    cd11998
    Location:431 → 486
    SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    pfam16601
    Location:342 → 430
    NPF; Rabosyn-5 repeating NPF sequence-motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVE8.1 GenPept UniProtKB/Swiss-Prot:Q9WVE8

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