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C1ql4 complement component 1, q subcomponent-like 4 [ Mus musculus (house mouse) ]

Gene ID: 239659, updated on 16-Apr-2024

Summary

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Official Symbol
C1ql4provided by MGI
Official Full Name
complement component 1, q subcomponent-like 4provided by MGI
Primary source
MGI:MGI:3579909
See related
Ensembl:ENSMUSG00000001076 AllianceGenome:MGI:3579909
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CTRP11; C1qtnf11
Summary
Enables identical protein binding activity. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of fat cell differentiation; and negative regulation of fibroblast proliferation. Located in extracellular space. Is expressed in brain and testis. Orthologous to human C1QL4 (complement C1q like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 2.0), whole brain E14.5 (RPKM 1.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F1; 15 55.84 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98981967..98988555, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99084086..99090674, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E947 Neighboring gene predicted gene, 34284 Neighboring gene trophinin associated protein Neighboring gene microRNA 6960 Neighboring gene DnaJ heat shock protein family (Hsp40) member C22 Neighboring gene spermatogenesis associated, serine-rich 2 Neighboring gene predicted gene, 57817 Neighboring gene predicted gene, 25183

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CTRP11 contributes modestly to systemic metabolism and energy balance. Sarver DC, et al. FASEB J, 2022 Jun. PMID 35579659, Free PMC Article
  2. Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion. Hamoud N, et al. Nat Commun, 2018 Oct 26. PMID 30367035, Free PMC Article
  3. C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. Wei Z, et al. J Biol Chem, 2013 Apr 12. PMID 23449976, Free PMC Article
  4. Distinct expression of C1q-like family mRNAs in mouse brain and biochemical characterization of their encoded proteins. Iijima T, et al. Eur J Neurosci, 2010 May. PMID 20525073
  5. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. Bolliger MF, et al. Proc Natl Acad Sci U S A, 2011 Feb 8. PMID 21262840, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CTRP11 contributes modestly to systemic metabolism and energy balance.
    Title: CTRP11 contributes modestly to systemic metabolism and energy balance.
  2. The secreted complement C1q-like protein 4 repress myoblast fusion by specifically interacting with G protein-coupled receptor BAI3.
    Title: Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.
  3. These results implicate CTRP11 as a novel secreted regulator of adipogenesis and highlight the potential paracrine cross-talk between adipocytes and cells of the stromal vascular compartment in maintaining adipose tissue homeostasis.
    Title: C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of fibroblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
complement C1q-like protein 4
Names
C1q and tumor necrosis factor-related protein 11
C1q/TNF-related protein 11
C1qTNF11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024702.1 → NP_001019873.1  complement C1q-like protein 4 precursor

    See identical proteins and their annotated locations for NP_001019873.1

    Status: PROVISIONAL

    Source sequence(s)
    DQ002403
    Consensus CDS
    CCDS27814.1
    UniProtKB/Swiss-Prot
    B2RV40, Q4ZJM9
    Related
    ENSMUSP00000068402.4, ENSMUST00000064462.5
    Conserved Domains (1) summary
    pfam00386
    Location:111 → 235
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98981967..98988555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520975.3 → XP_006521038.1  complement C1q-like protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006521038.1

    UniProtKB/Swiss-Prot
    B2RV40, Q4ZJM9
    Conserved Domains (1) summary
    pfam00386
    Location:111 → 235
    C1q; C1q domain

  2. XM_030248564.1 → XP_030104424.1  complement C1q-like protein 4 isoform X1

    UniProtKB/Swiss-Prot
    B2RV40, Q4ZJM9
    Conserved Domains (1) summary
    pfam00386
    Location:111 → 235
    C1q; C1q domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4ZJM9.1 GenPept UniProtKB/Swiss-Prot:Q4ZJM9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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