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Zfp641 zinc finger protein 641 [ Mus musculus (house mouse) ]

Gene ID: 239652, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp641provided by MGI
Official Full Name
zinc finger protein 641provided by MGI
Primary source
MGI:MGI:2442788
See related
Ensembl:ENSMUSG00000022987 AllianceGenome:MGI:2442788
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf641; 9930016F01Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be active in nucleoplasm. Orthologous to human ZNF641 (zinc finger protein 641). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 6.6), lung adult (RPKM 3.3) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 F1; 15 54.29 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98183466..98194395, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98285585..98296515, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily AD member 1B Neighboring gene STARR-seq mESC enhancer starr_39658 Neighboring gene H1.7 linker histone Neighboring gene predicted gene, 33967 Neighboring gene STARR-seq mESC enhancer starr_39659 Neighboring gene olfactory receptor family 8 subfamily S member 16 Neighboring gene STARR-seq mESC enhancer starr_39660 Neighboring gene STARR-seq mESC enhancer starr_39661 Neighboring gene olfactory receptor family 8 subfamily S member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. An atlas of combinatorial transcriptional regulation in mouse and man. Ravasi T, et al. Cell, 2010 Mar 5. PMID 20211142, Free PMC Article
  2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 641

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358068.1 → NP_001344997.1  zinc finger protein 641 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC105982
    Consensus CDS
    CCDS88831.1
    Related
    ENSMUSP00000023722.6, ENSMUST00000023722.12
    Conserved Domains (4) summary
    PLN03206
    Location:2 → 118
    PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
    smart00349
    Location:91 → 141
    KRAB; krueppel associated box
    COG5048
    Location:223 → 393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 258
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_173769.4 → NP_776130.1  zinc finger protein 641 isoform 1

    See identical proteins and their annotated locations for NP_776130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC105982
    Consensus CDS
    CCDS27789.1
    UniProtKB/Swiss-Prot
    Q14DN8, Q8BZ34
    Related
    ENSMUSP00000133212.2, ENSMUST00000169721.3
    Conserved Domains (4) summary
    PLN03206
    Location:2 → 90
    PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
    smart00349
    Location:95 → 155
    KRAB; krueppel associated box
    COG5048
    Location:237 → 407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252 → 272
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    98183466..98194395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316604.3 → XP_017172093.1  zinc finger protein 641 isoform X2

    UniProtKB/Swiss-Prot
    Q8BZ34
    Conserved Domains (4) summary
    PLN03206
    Location:2 → 118
    PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
    smart00349
    Location:91 → 141
    KRAB; krueppel associated box
    COG5048
    Location:223 → 393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 258
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006520970.5 → XP_006521033.1  zinc finger protein 641 isoform X1

    See identical proteins and their annotated locations for XP_006521033.1

    UniProtKB/Swiss-Prot
    Q14DN8, Q8BZ34
    Conserved Domains (4) summary
    PLN03206
    Location:2 → 90
    PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
    smart00349
    Location:95 → 155
    KRAB; krueppel associated box
    COG5048
    Location:237 → 407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252 → 272
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_036159406.1 → XP_036015299.1  zinc finger protein 641 isoform X5

    Conserved Domains (3) summary
    COG5048
    Location:229 → 290
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:128 → 148
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:154 → 176
    zf-C2H2; Zinc finger, C2H2 type

  4. XM_006520971.5 → XP_006521034.1  zinc finger protein 641 isoform X2

    See identical proteins and their annotated locations for XP_006521034.1

    UniProtKB/Swiss-Prot
    Q8BZ34
    Conserved Domains (4) summary
    PLN03206
    Location:2 → 118
    PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
    smart00349
    Location:91 → 141
    KRAB; krueppel associated box
    COG5048
    Location:223 → 393
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:238 → 258
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_011245627.4 → XP_011243929.1  zinc finger protein 641 isoform X1

    See identical proteins and their annotated locations for XP_011243929.1

    UniProtKB/Swiss-Prot
    Q14DN8, Q8BZ34
    Conserved Domains (4) summary
    PLN03206
    Location:2 → 90
    PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
    smart00349
    Location:95 → 155
    KRAB; krueppel associated box
    COG5048
    Location:237 → 407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252 → 272
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_006520969.5 → XP_006521032.1  zinc finger protein 641 isoform X1

    See identical proteins and their annotated locations for XP_006521032.1

    UniProtKB/Swiss-Prot
    Q14DN8, Q8BZ34
    Conserved Domains (4) summary
    PLN03206
    Location:2 → 90
    PLN03206; phosphoribosylformylglycinamidine synthase; Provisional
    smart00349
    Location:95 → 155
    KRAB; krueppel associated box
    COG5048
    Location:237 → 407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:252 → 272
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_006520974.4 → XP_006521037.1  zinc finger protein 641 isoform X4

    Conserved Domains (3) summary
    smart00349
    Location:48 → 99
    KRAB; krueppel associated box
    COG5048
    Location:181 → 351
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196 → 216
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_006520973.5 → XP_006521036.1  zinc finger protein 641 isoform X3

    Conserved Domains (3) summary
    smart00349
    Location:53 → 113
    KRAB; krueppel associated box
    COG5048
    Location:195 → 365
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:210 → 230
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_875298.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BZ34.1 GenPept UniProtKB/Swiss-Prot:Q8BZ34

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