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Tenm1 teneurin transmembrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 23963, updated on 2-Apr-2024

Summary

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Official Symbol
Tenm1provided by MGI
Official Full Name
teneurin transmembrane protein 1provided by MGI
Primary source
MGI:MGI:1345185
See related
Ensembl:ENSMUSG00000016150 AllianceGenome:MGI:1345185
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Odz1; Odz2; ten-1; TCAP-1; Ten-m1
Summary
Enables protein heterodimerization activity and protein homodimerization activity. Involved in positive regulation of cellular component biogenesis; positive regulation of protein phosphorylation; and regulation of transcription by RNA polymerase III. Located in several cellular components, including extracellular region; nucleus; and perinuclear region of cytoplasm. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human TENM1 (teneurin transmembrane protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 5.4), CNS E18 (RPKM 3.6) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A4; X 23.21 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (41616743..42518045, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (42527866..43429168, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47067 Neighboring gene STARR-seq mESC enhancer starr_47068 Neighboring gene TEX13 family member D Neighboring gene SH2 domain containing 1A Neighboring gene predicted gene, 23705 Neighboring gene STARR-seq mESC enhancer starr_47070 Neighboring gene predicted gene, 46667 Neighboring gene predicted gene 14578 Neighboring gene STARR-seq mESC enhancer starr_47071 Neighboring gene predicted gene, 24763 Neighboring gene STARR-seq mESC enhancer starr_47072 Neighboring gene STARR-seq mESC enhancer starr_47073 Neighboring gene predicted gene 14579 Neighboring gene TEX13 family member C1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells. Trubiani G, et al. Brain Res, 2007 Oct 24. PMID 17900539
  2. Regulation of neurite growth in immortalized mouse hypothalamic neurons and rat hippocampal primary cultures by teneurin C-terminal-associated peptide-1. Al Chawaf A, et al. Neuroscience, 2007 Feb 23. PMID 17174479
  3. Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity. Wang L, et al. Brain Res Mol Brain Res, 2005 Feb 18. PMID 15710242
  4. A role for TENM1 mutations in congenital general anosmia. Alkelai A, et al. Clin Genet, 2016 Sep. PMID 27040985
  5. C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells. Chand D, et al. Mol Cell Neurosci, 2013 Jan. PMID 23026563

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results of our study, that describes a new Tenm1 mouse, agree with the hypothesis that TENM1 has a role in olfaction. However, additional studies should be done in larger Congenital general anosmia (CGA) cohorts, to provide statistical evidence that loss-of-function mutations in TENM1 can solely cause the disease in our and other CGA cases
    Title: A role for TENM1 mutations in congenital general anosmia.
  2. Our data provides novel evidence that TCAP-1 is structurally and functionally distinct from the larger teneurins
    Title: C-terminal processing of the teneurin proteins: independent actions of a teneurin C-terminal associated peptide in hippocampal cells.
  3. Our data provides novel evidence that functionally links the teneurin and dystroglycan systems and provides new insight into the molecular mechanisms by which TCAP-1 regulates cytoskeletal dynamics in hippocampal neurons
    Title: C-Terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an extracellular signal-regulated kinase-dependent stathmin- and filamin A-mediated mechanism in hippocampal cells.
  4. The TCAP-1 induces a significant decline in BDNF transcription and protein labeling in embyronic mouse immortalized hypothalamic neurons.
    Title: Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells.
  5. TCAP-1 attenuated the corticotropin-releasing factor (CRF)-induced increase in c-Fos expression in the limbic system: TCAP-1 may play a potential role in the stress regulation by blocking CRF-mediated activity in stress-sensitive areas of the brain
    Title: Teneurin C-terminal associated peptide (TCAP)-1 attenuates corticotropin-releasing factor (CRF)-induced c-Fos expression in the limbic system and modulates anxiety behavior in male Wistar rats.
  6. Thus, the TCAP-teneurin system may be part of a mechanism to protect neurons during trauma, such as hypoxia and ischemia.
    Title: Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells.
  7. These data suggest that TCAP acts, in part, as a functional region of the teneurins to regulate neurite and axonal growth of neurons.
    Title: Regulation of neurite growth in immortalized mouse hypothalamic neurons and rat hippocampal primary cultures by teneurin C-terminal-associated peptide-1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein heterodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
teneurin-1
Names
protein Odd Oz/ten-m homolog 1
tenascin-M1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011855.4 → NP_035985.2  teneurin-1

    See identical proteins and their annotated locations for NP_035985.2

    Status: VALIDATED

    Source sequence(s)
    AL831716, BC138860, BY729750
    Consensus CDS
    CCDS40953.1
    UniProtKB/Swiss-Prot
    Q8CAT1, Q9WTS4
    UniProtKB/TrEMBL
    A2ANM0
    Related
    ENSMUSP00000016294.8, ENSMUST00000016294.8
    Conserved Domains (8) summary
    COG3209
    Location:1824 → 2393
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1196 → 1235
    NHL; NHL repeat [structural motif]
    pfam07974
    Location:662 → 689
    EGF_2; EGF-like domain
    cl18310
    Location:1196 → 1527
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:709 → 751
    DSL; Delta serrate ligand
    pfam05593
    Location:1643 → 1677
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23 → 317
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2647 → 2724
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    41616743..42518045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318483.2 → XP_017173972.1  teneurin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q8CAT1, Q9WTS4
    UniProtKB/TrEMBL
    A2ANM0
    Conserved Domains (8) summary
    COG3209
    Location:1824 → 2393
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1196 → 1235
    NHL; NHL repeat [structural motif]
    pfam07974
    Location:662 → 689
    EGF_2; EGF-like domain
    cl18310
    Location:1196 → 1527
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:709 → 751
    DSL; Delta serrate ligand
    pfam05593
    Location:1643 → 1677
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23 → 317
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2647 → 2724
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  2. XM_011251006.4 → XP_011249308.1  teneurin-1 isoform X1

    See identical proteins and their annotated locations for XP_011249308.1

    UniProtKB/Swiss-Prot
    Q8CAT1, Q9WTS4
    UniProtKB/TrEMBL
    A2ANM0
    Related
    ENSMUSP00000110711.2, ENSMUST00000115059.8
    Conserved Domains (8) summary
    COG3209
    Location:1824 → 2393
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1196 → 1235
    NHL; NHL repeat [structural motif]
    pfam07974
    Location:662 → 689
    EGF_2; EGF-like domain
    cl18310
    Location:1196 → 1527
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:709 → 751
    DSL; Delta serrate ligand
    pfam05593
    Location:1643 → 1677
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23 → 317
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2647 → 2724
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  3. XM_006541491.5 → XP_006541554.1  teneurin-1 isoform X2

    Conserved Domains (8) summary
    COG3209
    Location:1823 → 2392
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1195 → 1234
    NHL; NHL repeat [structural motif]
    pfam07974
    Location:661 → 688
    EGF_2; EGF-like domain
    cl18310
    Location:1195 → 1526
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:708 → 750
    DSL; Delta serrate ligand
    pfam05593
    Location:1642 → 1676
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23 → 317
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2646 → 2723
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  4. XM_006541492.5 → XP_006541555.1  teneurin-1 isoform X3

    UniProtKB/TrEMBL
    A2ANL9
    Related
    ENSMUSP00000110710.2, ENSMUST00000115058.8
    Conserved Domains (8) summary
    COG3209
    Location:1817 → 2386
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1196 → 1225
    NHL; NHL repeat [structural motif]
    pfam07974
    Location:662 → 689
    EGF_2; EGF-like domain
    cl18310
    Location:1196 → 1520
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:709 → 751
    DSL; Delta serrate ligand
    pfam05593
    Location:1636 → 1670
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23 → 317
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2640 → 2717
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  5. XM_011251005.4 → XP_011249307.1  teneurin-1 isoform X1

    See identical proteins and their annotated locations for XP_011249307.1

    UniProtKB/Swiss-Prot
    Q8CAT1, Q9WTS4
    UniProtKB/TrEMBL
    A2ANM0
    Conserved Domains (8) summary
    COG3209
    Location:1824 → 2393
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1196 → 1235
    NHL; NHL repeat [structural motif]
    pfam07974
    Location:662 → 689
    EGF_2; EGF-like domain
    cl18310
    Location:1196 → 1527
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:709 → 751
    DSL; Delta serrate ligand
    pfam05593
    Location:1643 → 1677
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23 → 317
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2647 → 2724
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  6. XM_017318484.3 → XP_017173973.1  teneurin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q8CAT1, Q9WTS4
    UniProtKB/TrEMBL
    A2ANM0
    Conserved Domains (8) summary
    COG3209
    Location:1824 → 2393
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1196 → 1235
    NHL; NHL repeat [structural motif]
    pfam07974
    Location:662 → 689
    EGF_2; EGF-like domain
    cl18310
    Location:1196 → 1527
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:709 → 751
    DSL; Delta serrate ligand
    pfam05593
    Location:1643 → 1677
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23 → 317
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2647 → 2724
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin

  7. XM_011251007.4 → XP_011249309.1  teneurin-1 isoform X1

    See identical proteins and their annotated locations for XP_011249309.1

    UniProtKB/Swiss-Prot
    Q8CAT1, Q9WTS4
    UniProtKB/TrEMBL
    A2ANM0
    Conserved Domains (8) summary
    COG3209
    Location:1824 → 2393
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:1196 → 1235
    NHL; NHL repeat [structural motif]
    pfam07974
    Location:662 → 689
    EGF_2; EGF-like domain
    cl18310
    Location:1196 → 1527
    NHL; NHL repeat unit of beta-propeller proteins
    pfam01414
    Location:709 → 751
    DSL; Delta serrate ligand
    pfam05593
    Location:1643 → 1677
    RHS_repeat; RHS Repeat
    pfam06484
    Location:23 → 317
    Ten_N; Teneurin Intracellular Region
    pfam15636
    Location:2647 → 2724
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WTS4.1 GenPept UniProtKB/Swiss-Prot:Q9WTS4

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