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Slc2a13 solute carrier family 2 (facilitated glucose transporter), member 13 [ Mus musculus (house mouse) ]

Gene ID: 239606, updated on 11-Apr-2024

Summary

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Official Symbol
Slc2a13provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 13provided by MGI
Primary source
MGI:MGI:2146030
See related
Ensembl:ENSMUSG00000036298 AllianceGenome:MGI:2146030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm308; 6530403A04; A630029G22Rik
Summary
Enables protease binding activity. Predicted to be involved in myo-inositol transport and positive regulation of amyloid-beta formation. Located in organelle membrane. Is expressed in several structures, including brain; jaw; and thoracic segment skeleton. Orthologous to human SLC2A13 (solute carrier family 2 member 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 10.3), frontal lobe adult (RPKM 7.6) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Slc2a13 in Genome Data Viewer
Location:
15 E3; 15 46.05 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (91151894..91457467, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (91267691..91573261, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39495 Neighboring gene STARR-seq mESC enhancer starr_39496 Neighboring gene ATP-binding cassette, sub-family D member 2 Neighboring gene regulator of DNA class I crossover intermediates 1 Neighboring gene STARR-seq mESC enhancer starr_39497 Neighboring gene STARR-seq mESC enhancer starr_39498 Neighboring gene STARR-seq mESC enhancer starr_39499 Neighboring gene STARR-seq mESC enhancer starr_39500 Neighboring gene STARR-seq mESC enhancer starr_39501 Neighboring gene olfactomedin-like 2A pseudogene Neighboring gene tripartite motif-containing 59 pseudogene Neighboring gene STARR-seq mESC enhancer starr_39502 Neighboring gene STARR-positive B cell enhancer ABC_E8606 Neighboring gene STARR-positive B cell enhancer ABC_E4147 Neighboring gene leucine-rich repeat kinase 2 Neighboring gene STARR-seq mESC enhancer starr_39505 Neighboring gene RAS related protein 1b pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Regulated exocytosis of an H+/myo-inositol symporter at synapses and growth cones. Uldry M, et al. EMBO J, 2004 Feb 11. PMID 14749729, Free PMC Article
  2. Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH. Fu H, et al. Neurochem Int, 2012 Jul. PMID 22564531
  3. Evaluation of expression and function of the H+/myo-inositol transporter HMIT. Di Daniel E, et al. BMC Cell Biol, 2009 Jul 16. PMID 19607714, Free PMC Article
  4. Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage. Teranishi Y, et al. FEBS J, 2015 Sep. PMID 26094765
  5. Nutrient Transporter Gene Expression in the Early Conceptus-Implications From Two Mouse Models of Diabetic Pregnancy. Kappen C, et al. Front Cell Dev Biol, 2022. PMID 35478964, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC2A13 is a novel gamma-secretase associated protein that regulates amyloid beta production without affecting Notch cleavage.
    Title: Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage.
  2. astrocytes obtained directly from the brain express HMIT and is expressed in neurons
    Title: Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH.
  3. Inositol transport and homeostasis were unaffected in H+/myo-inositol transporter targeted null-mutant mice.
    Title: Evaluation of expression and function of the H+/myo-inositol transporter HMIT.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables myo-inositol transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables myo-inositol:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables myo-inositol:proton symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables protease binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in myo-inositol transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myo-inositol transport ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in astrocyte end-foot ISO
Inferred from Sequence Orthology
more info
  
located_in cell body ISO
Inferred from Sequence Orthology
more info
  
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
NOT located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
NOT located_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in organelle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proton myo-inositol cotransporter
Names
h(+)-myo-inositol cotransporter
h(+)-myo-inositol symporter
hmit
solute carrier family 2 member 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033633.3 → NP_001028805.2  proton myo-inositol cotransporter

    See identical proteins and their annotated locations for NP_001028805.2

    Status: VALIDATED

    Source sequence(s)
    AK039571, AK147341, BB429800
    Consensus CDS
    CCDS27761.2
    UniProtKB/Swiss-Prot
    Q3UHK1
    UniProtKB/TrEMBL
    Q0VDP1
    Related
    ENSMUSP00000104906.2, ENSMUST00000109283.2
    Conserved Domains (2) summary
    cd06174
    Location:75 → 580
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:78 → 598
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    91151894..91457467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004938837.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHK1.2 GenPept UniProtKB/Swiss-Prot:Q3UHK1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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