Neu2 neuraminidase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Neu2provided by MGI
Official Full Name: neuraminidase 2provided by MGI
Primary source: MGI:MGI:1344417
See related: Ensembl:ENSMUSG00000079434 AllianceGenome:MGI:1344417
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MBS; MSS; MTS
Summary: Enables exo-alpha-(2->3)-sialidase activity and exo-alpha-(2->8)-sialidase activity. Involved in ganglioside catabolic process and oligosaccharide catabolic process. Predicted to be located in cytosol. Predicted to be part of catalytic complex. Predicted to be active in cytoplasm; intracellular membrane-bounded organelle; and membrane. Is expressed in brain. Orthologous to human NEU2 (neuraminidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 11.9), kidney adult (RPKM 6.1) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 44.44 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (87501749..87525567)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (87574027..87597845)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lactate promotes myogenesis via activating H3K9 lactylation-dependent up-regulation of Neu2 expression.
Title: Lactate promotes myogenesis via activating H3K9 lactylation-dependent up-regulation of Neu2 expression.
Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects Skeletal Muscle Development.
Title: Downregulation of Zebrafish Cytosolic Sialidase Neu3.2 Affects Skeletal Muscle Development.
Defect in cytosolic Neu2 sialidase abrogates lipid metabolism and impairs muscle function in vivo.
Title: Defect in cytosolic Neu2 sialidase abrogates lipid metabolism and impairs muscle function in vivo.
Neu2 from thymus exhibited sialidase activity with fetuin at pH 7.0.
Title: Possible association of Neu2 with plasma membrane fraction from mouse thymus exhibited sialidase activity with fetuin at pH 7.0 but not at pH 4.5.
30-40% of B and C forms of Neu2 activity was located in the crude membrane-fraction, and hydrolyzed ganglioside effectively, while both soluble fraction showed particular behavior with substrate specificity.
Title: Specific expression of Neu2 type B in mouse thymus and the existence of a membrane-bound form in COS cells.
the lack of soluble sialidase activity in the SM/J mouse thymus is due to the thymus-specific low expression level of the Neu2 gene
Title: Low expression of Neu2 sialidase in the thymus of SM/J mice-existence of neuraminidase positive cells "Neu-medullocyte" in the murine thymus.
Our data demonstrate that IGF-1-induced myoblast differentiation and hypertrophy are driven, at least in part, by Neu2 upregulation and further support the significant role of cytosolic sialidase in myoblasts.
Title: Insulin-like growth factor 1 signaling regulates cytosolic sialidase Neu2 expression during myoblast differentiation and hypertrophy.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Neu2 (e-PCR), detects polymorphism
- UniSTS:508013

NoName (e-PCR)
- UniSTS:485038

NoName (e-PCR)
- UniSTS:234169

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables exo-alpha-(2->3)-sialidase activity	IDA Inferred from Direct Assay more info	PubMed
enables exo-alpha-(2->3)-sialidase activity	ISO Inferred from Sequence Orthology more info
enables exo-alpha-(2->6)-sialidase activity	IEA Inferred from Electronic Annotation more info
enables exo-alpha-(2->8)-sialidase activity	IDA Inferred from Direct Assay more info	PubMed
enables exo-alpha-(2->8)-sialidase activity	ISO Inferred from Sequence Orthology more info
enables exo-alpha-sialidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables exo-alpha-sialidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ganglioside catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ganglioside catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ganglioside catabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycoprotein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in oligosaccharide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in oligosaccharide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of catalytic complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sialidase-2

Names: N-acetyl-alpha-neuraminidase 2; brain sialidase; cystolic sialidase; cytosolic sialidase; murine thymic sialidase; skeletal muscle sialidase

NP_001153635.2

EC 3.2.1.18

NP_001153636.1

EC 3.2.1.18

NP_001153637.2

EC 3.2.1.18

NP_001407607.1

EC 3.2.1.18

NP_001407608.1

EC 3.2.1.18

NP_056565.1

EC 3.2.1.18

XP_006529587.1

EC 3.2.1.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.