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Foxred2 FAD-dependent oxidoreductase domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 239554, updated on 11-Apr-2024

Summary

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Official Symbol
Foxred2provided by MGI
Official Full Name
FAD-dependent oxidoreductase domain containing 2provided by MGI
Primary source
MGI:MGI:106315
See related
Ensembl:ENSMUSG00000016552 AllianceGenome:MGI:106315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm304; D15Bwg0759e; A430097D04Rik
Summary
Predicted to enable flavin adenine dinucleotide binding activity. Predicted to be involved in ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum lumen. Is expressed in brain; eye; gonad; and submandibular gland. Orthologous to human FOXRED2 (FAD dependent oxidoreductase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 11.3), cerebellum adult (RPKM 5.3) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See Foxred2 in Genome Data Viewer
Location:
15 E1; 15 36.92 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (77824722..77842701, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (77940522..77958503, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53901 Neighboring gene STARR-seq mESC enhancer starr_39132 Neighboring gene STARR-positive B cell enhancer ABC_E479 Neighboring gene thioredoxin 2 Neighboring gene STARR-positive B cell enhancer ABC_E3146 Neighboring gene eukaryotic translation initiation factor 3, subunit D Neighboring gene calcium channel, voltage-dependent, gamma subunit 2 Neighboring gene predicted gene, 46520 Neighboring gene STARR-seq mESC enhancer starr_39138

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
  
enables monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum lumen IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FAD-dependent oxidoreductase domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017983.3 → NP_001017983.2  FAD-dependent oxidoreductase domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_001017983.2

    Status: VALIDATED

    Source sequence(s)
    AL583886, AL589650
    Consensus CDS
    CCDS27607.1
    UniProtKB/Swiss-Prot
    Q3TCC4, Q3USW5, Q5RJH0
    Related
    ENSMUSP00000016696.7, ENSMUST00000016696.13
    Conserved Domains (1) summary
    pfam13738
    Location:25 → 240
    Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase

  2. NM_001168260.2 → NP_001161732.1  FAD-dependent oxidoreductase domain-containing protein 2 precursor

    See identical proteins and their annotated locations for NP_001161732.1

    Status: VALIDATED

    Source sequence(s)
    AL583886, AL589650
    Consensus CDS
    CCDS27607.1
    UniProtKB/Swiss-Prot
    Q3TCC4, Q3USW5, Q5RJH0
    Related
    ENSMUSP00000113403.2, ENSMUST00000117725.2
    Conserved Domains (1) summary
    pfam13738
    Location:25 → 240
    Pyr_redox_3; Pyridine nucleotide-disulphide oxidoreductase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    77824722..77842701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520943.5 → XP_006521006.1  FAD-dependent oxidoreductase domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    cl21454
    Location:26 → 311
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_036159400.1 → XP_036015293.1  FAD-dependent oxidoreductase domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    cl21454
    Location:31 → 373
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_006520945.4 → XP_006521008.1  FAD-dependent oxidoreductase domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    cl21454
    Location:26 → 311
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_004938836.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3USW5.1 GenPept UniProtKB/Swiss-Prot:Q3USW5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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