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Tmem74 transmembrane protein 74 [ Mus musculus (house mouse) ]

Gene ID: 239408, updated on 5-Mar-2024

Summary

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Official Symbol
Tmem74provided by MGI
Official Full Name
transmembrane protein 74provided by MGI
Primary source
MGI:MGI:2443417
See related
Ensembl:ENSMUSG00000054409 AllianceGenome:MGI:2443417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230382K22Rik
Summary
Predicted to be involved in macroautophagy. Predicted to act upstream of or within autophagy. Predicted to be located in cytoplasmic vesicle; lysosome; and membrane. Predicted to be integral component of membrane. Orthologous to human TMEM74 (transmembrane protein 74). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 1.9), whole brain E14.5 (RPKM 1.1) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B3.2; 15 16.82 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (43726741..43733462, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (43863345..43870059, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38554 Neighboring gene predicted gene, 53880 Neighboring gene predicted gene, 41316 Neighboring gene ER membrane protein complex subunit 2 Neighboring gene STARR-seq mESC enhancer starr_38556 Neighboring gene STARR-seq mESC enhancer starr_38557 Neighboring gene STARR-seq mESC enhancer starr_38558 Neighboring gene STARR-seq mESC enhancer starr_38559 Neighboring gene SUMO-conjugating enzyme UBC9 pseudogene Neighboring gene STARR-seq mESC enhancer starr_38560 Neighboring gene STARR-seq mESC enhancer starr_38561 Neighboring gene STARR-seq mESC enhancer starr_38563 Neighboring gene STARR-seq mESC enhancer starr_38565 Neighboring gene STARR-seq mESC enhancer starr_38567 Neighboring gene thyrotropin releasing hormone receptor Neighboring gene predicted gene, 33793

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons. Shao LX, et al. Mol Psychiatry, 2019 Oct. PMID 30886335
  2. CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Yu C, et al. Science, 2013 Dec 20. PMID 24357321
  3. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within general adaptation syndrome, behavioral process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within general adaptation syndrome, behavioral process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of cation channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transmembrane protein 74

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175502.3 → NP_780711.1  transmembrane protein 74

    See identical proteins and their annotated locations for NP_780711.1

    Status: PROVISIONAL

    Source sequence(s)
    AK046420
    Consensus CDS
    CCDS27454.1
    UniProtKB/Swiss-Prot
    Q8BQU7
    Related
    ENSMUSP00000070748.5, ENSMUST00000067469.6
    Conserved Domains (1) summary
    pfam14927
    Location:177 → 262
    Neurensin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    43726741..43733462 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520908.5 → XP_006520971.2  transmembrane protein 74 isoform X1

    UniProtKB/Swiss-Prot
    Q8BQU7
    Conserved Domains (1) summary
    pfam14927
    Location:177 → 262
    Neurensin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BQU7.1 GenPept UniProtKB/Swiss-Prot:Q8BQU7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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