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Lrp12 low density lipoprotein-related protein 12 [ Mus musculus (house mouse) ]

Gene ID: 239393, updated on 5-Mar-2024

Summary

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Official Symbol
Lrp12provided by MGI
Official Full Name
low density lipoprotein-related protein 12provided by MGI
Primary source
MGI:MGI:2443132
See related
Ensembl:ENSMUSG00000022305 AllianceGenome:MGI:2443132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LRP-12; C820005L12Rik
Summary
Acts upstream of or within neuron migration and neuron projection development. Predicted to be integral component of plasma membrane. Is expressed in nervous system; renal vasculature; sensory organ; and turbinate bone primordium. Orthologous to human LRP12 (LDL receptor related protein 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 8.6), whole brain E14.5 (RPKM 7.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 B3.1; 15 15.59 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (39733985..39807417, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (39870589..39944015, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene dihydropyrimidinase Neighboring gene predicted gene 16291 Neighboring gene predicted gene, 53879 Neighboring gene expressed sequence AU022793 Neighboring gene STARR-seq mESC enhancer starr_38497 Neighboring gene STARR-seq mESC enhancer starr_38498 Neighboring gene STARR-seq mESC enhancer starr_38499 Neighboring gene predicted gene, 33251

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization. Grote A, et al. Neurobiol Dis, 2016 Feb. PMID 26639854
  2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LRP12 is an endogenous transmembrane inactivator of alpha4 integrins.
    Title: LRP12 is an endogenous transmembrane inactivator of α4 integrins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347036.2 → NP_001333965.1  low-density lipoprotein receptor-related protein 12 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    BC039793, BC058345
    Consensus CDS
    CCDS84168.1
    UniProtKB/Swiss-Prot
    Q8BUJ9
    Related
    ENSMUSP00000105934.3, ENSMUST00000110305.3

  2. NM_172814.4 → NP_766402.1  low-density lipoprotein receptor-related protein 12 isoform 1 precursor

    See identical proteins and their annotated locations for NP_766402.1

    Status: VALIDATED

    Source sequence(s)
    AC101945, AC158567
    Consensus CDS
    CCDS27446.1
    UniProtKB/Swiss-Prot
    Q8BUJ9, Q8BWM9
    Related
    ENSMUSP00000022916.6, ENSMUST00000022916.13
    Conserved Domains (2) summary
    cd00041
    Location:56 → 158
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:451 → 485
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    39733985..39807417 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006520903.5 → XP_006520966.1  low-density lipoprotein receptor-related protein 12 isoform X2

    Conserved Domains (3) summary
    cd00041
    Location:249 → 353
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:433 → 467
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00431
    Location:28 → 137
    CUB; CUB domain

  2. XM_006520902.4 → XP_006520965.1  low-density lipoprotein receptor-related protein 12 isoform X1

    Conserved Domains (3) summary
    cd00041
    Location:268 → 372
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:452 → 486
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00431
    Location:47 → 156
    CUB; CUB domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BUJ9.2 GenPept UniProtKB/Swiss-Prot:Q8BUJ9

Gene LinkOut

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