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Mapk7 mitogen-activated protein kinase 7 [ Mus musculus (house mouse) ]

Gene ID: 23939, updated on 16-Apr-2024

Summary

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Official Symbol
Mapk7provided by MGI
Official Full Name
mitogen-activated protein kinase 7provided by MGI
Primary source
MGI:MGI:1346347
See related
Ensembl:ENSMUSG00000001034 AllianceGenome:MGI:1346347
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BMK1; ERK5; BMK-1; ERK-5; PRKM7; Erk5-T; b2b2346Clo
Summary
Enables protein serine/threonine kinase activity. Involved in protein phosphorylation. Acts upstream of or within several processes, including negative regulation of intracellular signal transduction; peptidyl-serine phosphorylation; and regulation of angiogenesis. Located in cytosol and nucleus. Is expressed in several structures, including cardiovascular system; early conceptus; ganglia; genitourinary system; and salivary gland. Orthologous to human MAPK7 (mitogen-activated protein kinase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 31.7), whole brain E14.5 (RPKM 29.9) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B2; 11 37.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61379638..61385101, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61488812..61494267, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 112 Neighboring gene STARR-positive B cell enhancer ABC_E6995 Neighboring gene microfibrillar-associated protein 4 Neighboring gene B9 protein domain 1, opposite strand Neighboring gene B9 protein domain 1 Neighboring gene epsin 2 Neighboring gene STARR-seq mESC enhancer starr_29682

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling. Jiang Y, et al. Diabetes Obes Metab, 2022 Sep. PMID 35546452
  2. Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood. Horie T, et al. Stem Cells, 2022 Apr 29. PMID 35304894
  3. ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum. Nakagawasai O, et al. J Pharmacol Sci, 2022 Mar. PMID 35177212
  4. Fluid Shear Stress Suppresses Osteoclast Differentiation in RAW264.7 Cells through Extracellular Signal-Regulated Kinase 5 (ERK5) Signaling Pathway. Ma C, et al. Med Sci Monit, 2020 Jan 8. PMID 31914120, Free PMC Article
  5. Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype. Cameron SJ, et al. Arterioscler Thromb Vasc Biol, 2018 Jul. PMID 29724818, Free PMC Article

See all (145) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
    Title: HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
  2. Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation.
    Title: Aerobic Exercise Alters the Melanoma Microenvironment and Modulates ERK5 S496 Phosphorylation.
  3. An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis.
    Title: An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis.
  4. Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling.
    Title: Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling.
  5. Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood.
    Title: Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood.
  6. ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum.
    Title: ERK5 inhibitor BIX02189 attenuates methamphetamine-induced hyperactivity by modulating microglial activation in the striatum.
  7. ERK5 negatively regulates Kruppel-like factor 4 and promotes osteogenic lineage cell proliferation in response to MEK5 overexpression or fluid shear stress.
    Title: ERK5 negatively regulates Kruppel-like factor 4 and promotes osteogenic lineage cell proliferation in response to MEK5 overexpression or fluid shear stress.
  8. An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.
    Title: An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.
  9. MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression.
    Title: MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression.
  10. Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner.
    Title: Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner.
Submit: New GeneRIF Correction See all GeneRIFs (108)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERK5 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to laminar fluid shear stress ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of smooth muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 7
Names
MAPK 7
big MAP kinase 1
extracellular signal-regulated kinase 5
NP_001277962.1
NP_001277963.1
NP_001277964.1
NP_001277965.1
NP_001277966.1
NP_001348918.1
NP_035971.1
XP_006533340.1
XP_006533343.1
XP_006533347.1
XP_006533348.1
XP_006533349.1
XP_030101845.1
XP_030101846.1
XP_030101847.1
XP_030101848.1
XP_030101849.1
XP_030101850.1
XP_030101851.1
XP_030101853.1
XP_036012575.1
XP_036012576.1
XP_036012577.1
XP_036012578.1
XP_036012579.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291033.1 → NP_001277962.1  mitogen-activated protein kinase 7 isoform b

    See identical proteins and their annotated locations for NP_001277962.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR uses an alternate start codon, compared to variant 1. The encoded isoform (b) has a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AF126160, AY534740, BY207876
    Consensus CDS
    CCDS70205.1
    UniProtKB/Swiss-Prot
    Q9WVS8
    Related
    ENSMUSP00000104354.2, ENSMUST00000108714.2
    Conserved Domains (1) summary
    cd07855
    Location:6 → 315
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  2. NM_001291034.1 → NP_001277963.1  mitogen-activated protein kinase 7 isoform a

    See identical proteins and their annotated locations for NP_001277963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AY534740, BC100398, BY207876
    Consensus CDS
    CCDS24814.1
    UniProtKB/Swiss-Prot
    Q3U2N7, Q3UG52, Q497T0, Q5NCN6, Q5NCN7, Q5NCN9, Q6QLU8, Q9R1D9, Q9WVF3, Q9WVF4, Q9WVS8
    Conserved Domains (1) summary
    cd07855
    Location:49 → 384
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  3. NM_001291035.1 → NP_001277964.1  mitogen-activated protein kinase 7 isoform c

    See identical proteins and their annotated locations for NP_001277964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in its 5' UTR uses a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AY534740, BC082315, BY207876
    UniProtKB/Swiss-Prot
    Q9WVS8
    Related
    ENSMUST00000152755.8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001291036.1 → NP_001277965.1  mitogen-activated protein kinase 7 isoform c

    See identical proteins and their annotated locations for NP_001277965.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in its 5' UTR uses a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a. Both variants 4 and 5 encode the same isoform.
    Source sequence(s)
    AY534740, BY207876, CA320276
    UniProtKB/Swiss-Prot
    Q9WVS8
    Related
    ENSMUST00000125840.8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001291037.1 → NP_001277966.1  mitogen-activated protein kinase 7 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR, uses an alternate start codon, and uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AF126161, AY534740, BC058096, BY207876
    Consensus CDS
    CCDS78963.1
    UniProtKB/TrEMBL
    Q5NCN8
    Related
    ENSMUSP00000098646.3, ENSMUST00000101085.9
    Conserved Domains (2) summary
    smart00220
    Location:8 → 277
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:8 → 314
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  6. NM_001361989.1 → NP_001348918.1  mitogen-activated protein kinase 7 isoform c

    Status: VALIDATED

    Source sequence(s)
    AY534740, BB868535, BC082315, CA315160
    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  7. NM_011841.2 → NP_035971.1  mitogen-activated protein kinase 7 isoform a

    See identical proteins and their annotated locations for NP_035971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AY534740, BY207876
    Consensus CDS
    CCDS24814.1
    UniProtKB/Swiss-Prot
    Q3U2N7, Q3UG52, Q497T0, Q5NCN6, Q5NCN7, Q5NCN9, Q6QLU8, Q9R1D9, Q9WVF3, Q9WVF4, Q9WVS8
    Related
    ENSMUSP00000078087.7, ENSMUST00000079080.13
    Conserved Domains (1) summary
    cd07855
    Location:49 → 384
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61379638..61385101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006533277.5 → XP_006533340.1  mitogen-activated protein kinase 7 isoform X1

    See identical proteins and their annotated locations for XP_006533340.1

    UniProtKB/Swiss-Prot
    Q3U2N7, Q3UG52, Q497T0, Q5NCN6, Q5NCN7, Q5NCN9, Q6QLU8, Q9R1D9, Q9WVF3, Q9WVF4, Q9WVS8
    Conserved Domains (1) summary
    cd07855
    Location:49 → 384
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  2. XM_030245986.2 → XP_030101846.1  mitogen-activated protein kinase 7 isoform X2

    Conserved Domains (1) summary
    cd07855
    Location:6 → 315
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  3. XM_030245993.2 → XP_030101853.1  mitogen-activated protein kinase 7 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  4. XM_030245989.2 → XP_030101849.1  mitogen-activated protein kinase 7 isoform X3

    Conserved Domains (1) summary
    cd07855
    Location:8 → 314
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  5. XM_006533285.5 → XP_006533348.1  mitogen-activated protein kinase 7 isoform X4

    See identical proteins and their annotated locations for XP_006533348.1

    UniProtKB/Swiss-Prot
    Q9WVS8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  6. XM_036156683.1 → XP_036012576.1  mitogen-activated protein kinase 7 isoform X3

    Conserved Domains (1) summary
    cd07855
    Location:8 → 314
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  7. XM_006533284.5 → XP_006533347.1  mitogen-activated protein kinase 7 isoform X4

    See identical proteins and their annotated locations for XP_006533347.1

    UniProtKB/Swiss-Prot
    Q9WVS8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  8. XM_030245987.2 → XP_030101847.1  mitogen-activated protein kinase 7 isoform X3

    Conserved Domains (1) summary
    cd07855
    Location:8 → 314
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  9. XM_036156684.1 → XP_036012577.1  mitogen-activated protein kinase 7 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  10. XM_030245988.2 → XP_030101848.1  mitogen-activated protein kinase 7 isoform X3

    Conserved Domains (1) summary
    cd07855
    Location:8 → 314
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  11. XM_006533286.5 → XP_006533349.1  mitogen-activated protein kinase 7 isoform X4

    See identical proteins and their annotated locations for XP_006533349.1

    UniProtKB/Swiss-Prot
    Q9WVS8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  12. XM_036156686.1 → XP_036012579.1  mitogen-activated protein kinase 7 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  13. XM_030245985.2 → XP_030101845.1  mitogen-activated protein kinase 7 isoform X2

    Conserved Domains (1) summary
    cd07855
    Location:6 → 315
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  14. XM_036156685.1 → XP_036012578.1  mitogen-activated protein kinase 7 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  15. XM_036156682.1 → XP_036012575.1  mitogen-activated protein kinase 7 isoform X3

    Conserved Domains (1) summary
    cd07855
    Location:8 → 314
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  16. XM_030245990.2 → XP_030101850.1  mitogen-activated protein kinase 7 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  17. XM_030245991.2 → XP_030101851.1  mitogen-activated protein kinase 7 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain

  18. XM_006533280.5 → XP_006533343.1  mitogen-activated protein kinase 7 isoform X4

    See identical proteins and their annotated locations for XP_006533343.1

    UniProtKB/Swiss-Prot
    Q9WVS8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 245
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVS8.1 GenPept UniProtKB/Swiss-Prot:Q9WVS8

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