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Ly6h lymphocyte antigen 6 family member H [ Mus musculus (house mouse) ]

Gene ID: 23934, updated on 11-Apr-2024

Summary

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Official Symbol
Ly6hprovided by MGI
Official Full Name
lymphocyte antigen 6 family member Hprovided by MGI
Primary source
MGI:MGI:1346030
See related
Ensembl:ENSMUSG00000022577 AllianceGenome:MGI:1346030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables acetylcholine receptor binding activity and acetylcholine receptor inhibitor activity. Acts upstream of or within acetylcholine receptor signaling pathway. Predicted to be located in membrane. Predicted to be anchored component of membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; dorsal root ganglion; and sensory organ. Orthologous to human LY6H (lymphocyte antigen 6 family member H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 141.2), whole brain E14.5 (RPKM 99.2) and 7 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 34.52 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75436594..75439114, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75564745..75569470, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34593 Neighboring gene predicted gene, 34646 Neighboring gene GPI-anchored HDL-binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1174 Neighboring gene zinc finger protein 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ly6h regulates trafficking of alpha7 nicotinic acetylcholine receptors and nicotine-induced potentiation of glutamatergic signaling. Puddifoot CA, et al. J Neurosci, 2015 Feb 25. PMID 25716842, Free PMC Article
  2. Identification of mouse Ly6H and its expression in normal tissue. Apostolopoulos J, et al. Immunogenetics, 1999 Oct. PMID 10501842
  3. Endogenous neurotoxin-like protein Ly6H inhibits alpha7 nicotinic acetylcholine receptor currents at the plasma membrane. Moriwaki Y, et al. Sci Rep, 2020 Jul 20. PMID 32686737, Free PMC Article
  4. Mouse Ly-6 proteins and their extended family: markers of cell differentiation and regulators of cell signaling. Bamezai A. Arch Immunol Ther Exp (Warsz), 2004 Jul-Aug. PMID 15467490
  5. Identification of lynx2, a novel member of the ly-6/neurotoxin superfamily, expressed in neuronal subpopulations during mouse development. Dessaud E, et al. Mol Cell Neurosci, 2006 Feb. PMID 16236524

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endogenous neurotoxin-like protein Ly6H inhibits alpha7 nicotinic acetylcholine receptor currents at the plasma membrane.
    Title: Endogenous neurotoxin-like protein Ly6H inhibits alpha7 nicotinic acetylcholine receptor currents at the plasma membrane.
  2. Ly6h regulates alpha7 nAChRs cell-surface expression and nicotine-induced potentiation of glutamatergic mEPSC.
    Title: Ly6h regulates trafficking of alpha7 nicotinic acetylcholine receptors and nicotine-induced potentiation of glutamatergic signaling.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylcholine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetylcholine receptor inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetylcholine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acetylcholine receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lymphocyte antigen 6H
Names
ly-6H
lymphocyte antigen 6 complex, locus H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135688.2 → NP_001129160.1  lymphocyte antigen 6H isoform b precursor

    See identical proteins and their annotated locations for NP_001129160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 5 and 6 encode the same isoform (b).
    Source sequence(s)
    AC121359
    Consensus CDS
    CCDS49640.1
    UniProtKB/Swiss-Prot
    Q9WUC3
    UniProtKB/TrEMBL
    Q544M1
    Related
    ENSMUSP00000070646.9, ENSMUST00000065417.15
    Conserved Domains (1) summary
    pfam00021
    Location:28 → 110
    UPAR_LY6; u-PAR/Ly-6 domain

  2. NM_001135689.2 → NP_001129161.1  lymphocyte antigen 6H isoform b precursor

    See identical proteins and their annotated locations for NP_001129161.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 5 and 6 encode the same isoform (b).
    Source sequence(s)
    AC121359
    Consensus CDS
    CCDS49640.1
    UniProtKB/Swiss-Prot
    Q9WUC3
    UniProtKB/TrEMBL
    Q544M1
    Related
    ENSMUSP00000023241.6, ENSMUST00000023241.12
    Conserved Domains (1) summary
    pfam00021
    Location:28 → 110
    UPAR_LY6; u-PAR/Ly-6 domain

  3. NM_001411856.1 → NP_001398785.1  lymphocyte antigen 6H isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1 and 4 encode the same isoform (a).
    Source sequence(s)
    AC121359
    UniProtKB/TrEMBL
    Q8K356
    Related
    ENSMUSP00000122878.2, ENSMUST00000156032.2

  4. NM_001411857.1 → NP_001398786.1  lymphocyte antigen 6H isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 5 and 6 encode the same isoform (b).
    Source sequence(s)
    AC121359
    UniProtKB/Swiss-Prot
    Q9WUC3
    UniProtKB/TrEMBL
    Q544M1

  5. NM_001411858.1 → NP_001398787.1  lymphocyte antigen 6H isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1, resulting in an isoform (b) that is shorter at the N-terminus, compared to isoform a. Variants 2, 3, 5 and 6 encode the same isoform (b).
    Source sequence(s)
    AC121359
    UniProtKB/Swiss-Prot
    Q9WUC3
    UniProtKB/TrEMBL
    Q544M1

  6. NM_011837.4 → NP_035967.1  lymphocyte antigen 6H isoform a precursor

    See identical proteins and their annotated locations for NP_035967.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 4 encode the same isoform (a).
    Source sequence(s)
    AC121359
    Consensus CDS
    CCDS27544.1
    UniProtKB/TrEMBL
    Q8K356
    Related
    ENSMUSP00000122061.2, ENSMUST00000127095.8
    Conserved Domains (1) summary
    pfam00021
    Location:49 → 131
    UPAR_LY6; u-PAR/Ly-6 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75436594..75439114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248535.1 → XP_030104395.1  lymphocyte antigen 6H isoform X3

    UniProtKB/Swiss-Prot
    Q9WUC3
    UniProtKB/TrEMBL
    Q544M1
    Conserved Domains (1) summary
    pfam00021
    Location:28 → 110
    UPAR_LY6; u-PAR/Ly-6 domain

  2. XM_030248536.2 → XP_030104396.1  lymphocyte antigen 6H isoform X3

    UniProtKB/Swiss-Prot
    Q9WUC3
    UniProtKB/TrEMBL
    Q544M1
    Conserved Domains (1) summary
    pfam00021
    Location:28 → 110
    UPAR_LY6; u-PAR/Ly-6 domain

  3. XM_006520901.2 → XP_006520964.1  lymphocyte antigen 6H isoform X3

    See identical proteins and their annotated locations for XP_006520964.1

    UniProtKB/Swiss-Prot
    Q9WUC3
    UniProtKB/TrEMBL
    Q544M1
    Conserved Domains (1) summary
    pfam00021
    Location:28 → 110
    UPAR_LY6; u-PAR/Ly-6 domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUC3.2 GenPept UniProtKB/Swiss-Prot:Q9WUC3

Gene LinkOut

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