Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Adamts12provided by MGI
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 12provided by MGI
Primary source: MGI:MGI:2146046
See related: Ensembl:ENSMUSG00000047497 AllianceGenome:MGI:2146046
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ADAMTS-12
Summary: This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Mice lacking the encoded protein exhibit increased angiogenic response and tumor invasion in different models of angiogenesis and, severe inflammation and delayed recovery when subjected to experimental conditions that induce colitis, endotoxic sepsis and pancreatitis. [provided by RefSeq, Jul 2016]
Expression: Biased expression in mammary gland adult (RPKM 5.1), subcutaneous fat pad adult (RPKM 4.1) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 A1; 15 5.43 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (11064781..11349321)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (11064773..11349232)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2 and ADAMTS-12.
Title: Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2 and ADAMTS-12.
ADAMTS12 is a stromal modulator in chronic liver disease.
Title: ADAMTS12 is a stromal modulator in chronic liver disease.
Identification of relevant genetic alterations in cancer using topological data analysis.
Title: Identification of relevant genetic alterations in cancer using topological data analysis.
Adamts7-/- Adamts12-/- mice, but not corresponding single-gene mutants, develop progressive heterotopic ossification (HO) in tendons with abnormal collagen fibrils, accompanied by reduced levels of the small leucine-rich proteoglycans which regulate collagen fibrillogenesis. These results suggest that Adamts7 and Adamts12 drive an innate pathway protective against hindlimb HO in mice.
Title: The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification.
This study provides evidence that ADAMTS-12 is a critical regulator of inflammatory arthritis and that this is mediated, at least in part, through control of CTGF turnover.
Title: Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor.
ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review]
Title: ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation.
ADAMTS-12 is implicated in the inflammatory response by modulating normal neutrophil apoptosis.
Title: ADAMTS-12 metalloprotease is necessary for normal inflammatory response.
ADAMTS-12 plays protective roles acting against the development of asthma phenotype upon experimental allergen exposure, interfering with immunological processes leading to inflammation and airway hyperresponsiveness.
Title: Control of allergen-induced inflammation and hyperresponsiveness by the metalloproteinase ADAMTS-12.
Results define a break point in mouse chromosome 15qA1 to a 27-kb region containing ADAMTS12, and show that the break is likely between exons 2 and 3 of ADAMTS12.
Title: The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene.
Absence of Adamts-12 is associated with the increase in angiogenic response and tumor invasion into host tissue.
Title: Higher sensitivity of Adamts12-deficient mice to tumor growth and angiogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation
Targeted (2) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Adamts12 (e-PCR), detects polymorphism
- UniSTS:532640

AI605170 (e-PCR)
- UniSTS:164572

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-1	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in collagen fibril organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cellular response to hepatocyte growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hepatocyte growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ossification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ossification involved in bone maturation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteoglycan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of endothelial tube morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of inflammatory response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: A disintegrin and metalloproteinase with thrombospondin motifs 12

Names: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175501.3 → NP_780710.2 A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein

See identical proteins and their annotated locations for NP_780710.2

Status: REVIEWED

Source sequence(s)

AC159963, AI605170, AJ537452, AK028459, AK028812, AK135354, BB839765

Consensus CDS

CCDS27384.1

UniProtKB/Swiss-Prot

E9QKD6, Q811B3, Q8BK92, Q8BKY1

Related

ENSMUSP00000057796.8, ENSMUST00000061318.9

Conserved Domains (6) summary

smart00209
Location:549 → 600

TSP1; Thrombospondin type 1 repeats

cd04273
Location:250 → 457

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam01421
Location:250 → 460

Reprolysin; Reprolysin (M12B) family zinc metalloprotease

pfam01562
Location:80 → 196

Pep_M12B_propep; Reprolysin family propeptide

pfam05986
Location:706 → 816

ADAM_spacer1; ADAM-TS Spacer 1

cl15456
Location:519 → 680

ADAM_CR; ADAM cysteine-rich

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

11064781..11349321

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159390.1 → XP_036015283.1 A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X1

Conserved Domains (7) summary

smart00209
Location:549 → 600

TSP1; Thrombospondin type 1 repeats

cd04273
Location:250 → 457

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:706 → 816

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:53 → 197

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:472 → 536

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:1433 → 1489

TSP1_ADAMTS; Thrombospondin type 1 domain

cl15456
Location:519 → 680

ADAM_CR; ADAM cysteine-rich
XM_036159391.1 → XP_036015284.1 A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X2

Conserved Domains (7) summary

smart00209
Location:549 → 600

TSP1; Thrombospondin type 1 repeats

cd04273
Location:250 → 457

ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...

pfam05986
Location:706 → 816

ADAM_spacer1; ADAM-TS Spacer 1

pfam01562
Location:53 → 197

Pep_M12B_propep; Reprolysin family propeptide

pfam17771
Location:472 → 536

ADAM_CR_2; ADAM cysteine-rich domain

pfam19030
Location:1421 → 1477

TSP1_ADAMTS; Thrombospondin type 1 domain

cl15456
Location:519 → 680

ADAM_CR; ADAM cysteine-rich
XM_036159392.1 → XP_036015285.1 A disintegrin and metalloproteinase with thrombospondin motifs 12 isoform X3

Conserved Domains (2) summary

pfam05986
Location:150 → 260

ADAM_spacer1; ADAM-TS Spacer 1

pfam19030
Location:925 → 981

TSP1_ADAMTS; Thrombospondin type 1 domain