Lamc3 laminin gamma 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lamc3provided by MGI
Official Full Name: laminin gamma 3provided by MGI
Primary source: MGI:MGI:1344394
See related: Ensembl:ENSMUSG00000026840 AllianceGenome:MGI:1344394
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110064A23Rik
Summary: Acts upstream of or within several processes, including astrocyte development; retina development in camera-type eye; and visual perception. Located in basement membrane. Is expressed in central nervous system; lower jaw molar epithelium; oral region gland; retina; and vibrissa. Orthologous to human LAMC3 (laminin subunit gamma 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in ovary adult (RPKM 25.0), adrenal adult (RPKM 10.6) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 B

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (31777293..31839095)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (31887281..31949083)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Lamb2 and Lamc3 genes affects astrocyte migration and spatial patterning in the retina.
Title: Laminins containing the β2 and γ3 chains regulate astrocyte migration and angiogenesis in the retina.
gamma3-containing laminins are expressed in a wide variety of basement membranes. gamma3 is expressed in CNS but not peripheral vascular basement membranes.
Title: The γ3 chain of laminin is widely but differentially expressed in murine basement membranes: expression and functional studies.
a strong impact of laminin beta2 and gamma3 subunits on the expression and function of both aquaporin-4 and Kir4.1, two important membrane proteins in Muller cells.
Title: Genetic deletion of laminin isoforms β2 and γ3 induces a reduction in Kir4.1 and aquaporin-4 expression and function in the retina.
In human but not mouse fetal brain, LAMC3 is enriched in postmitotic cortical plate neurons, localizing primarily to the somatodendritic compartment.
Title: Recessive LAMC3 mutations cause malformations of occipital cortical development.
netrin-4 is a component of basement membranes and is integrated into the laminin polymer via interactions with the laminin gamma1 andgamma3 short arms
Title: Binding of netrin-4 to laminin short arms regulates basement membrane assembly.
Laminin gamma3 chain, located in murine basement membranes, binds to nidogen
Title: Laminin gamma3 chain binds to nidogen and is located in murine basement membranes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI562206 (e-PCR)
- UniSTS:165160

AW240805 (e-PCR)
- UniSTS:178601

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within astrocyte development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual perception	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info

General protein information

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Preferred Names: laminin subunit gamma-3

Names: laminin-12 subunit gamma; laminin-14 subunit gamma; laminin-15 subunit gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011836.4 → NP_035966.2 laminin subunit gamma-3 precursor

See identical proteins and their annotated locations for NP_035966.2

Status: VALIDATED

Source sequence(s)

AL928893, BX511243

Consensus CDS

CCDS15903.1

UniProtKB/Swiss-Prot

Q4VAI3, Q9R0B6, Q9WTW6

UniProtKB/TrEMBL

A2ATM9

Related

ENSMUSP00000028187.7, ENSMUST00000028187.7

Conserved Domains (6) summary

cd00055
Location:391 → 437

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00052
Location:550 → 669

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:928 → 976

Laminin_EGF; Laminin EGF domain

pfam00055
Location:53 → 278

Laminin_N; Laminin N-terminal (Domain VI)

pfam06008
Location:1225 → 1470

Laminin_I; Laminin Domain I

cl14813
Location:1433 → 1506

GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)