Insrr insulin receptor-related receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Insrrprovided by MGI
Official Full Name: insulin receptor-related receptorprovided by MGI
Primary source: MGI:MGI:1346037
See related: Ensembl:ENSMUSG00000005640 AllianceGenome:MGI:1346037
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Irr
Summary: Predicted to enable insulin receptor substrate binding activity and insulin-activated receptor activity. Involved in cellular response to alkaline pH and protein autophosphorylation. Acts upstream of or within male sex determination. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of insulin receptor complex. Predicted to be active in axon. Predicted to be integral component of plasma membrane. Is expressed in brain; ganglia; metanephros; and pancreas. Orthologous to human INSRR (insulin receptor related receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in kidney adult (RPKM 10.4), colon adult (RPKM 3.5) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 38.7 cM

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (87704215..87723408)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (87796908..87816101)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Changes in the Expression of the gapdh Gene in the Organs of insrr Knockout Mice.
Title: Changes in the Expression of the gapdh Gene in the Organs of insrr Knockout Mice.
The obtained data suggest that the IRR gene inactivation results in disturbances of the aggressive-defensive behavior typical of the parental mouse strain c57bl.
Title: [Behavioral Phenotype of Mice with Alkali Sensor IRR Gene Knockout].
The activation of IRR by alkali might be part of a local loop of signaling between the exocrine and endocrine parts of the pancreas where alkalinization of the juice facilitate insulin release that increases the volume of secreted juice to control its pH and bicabonate content.
Title: Alkaline pH induces IRR-mediated phosphorylation of IRS-1 and actin cytoskeleton remodeling in a pancreatic beta cell line.
Disruption of insulin receptor-related receptor in mice impairs the renal response to alkali loading attested by development of metabolic alkalosis and decreased urinary bicarbonate excretion in response to this challenge
Title: Insulin receptor-related receptor as an extracellular alkali sensor.
Insulin receptor substrates 1 and 2 (IRS-1 and IRS-2) were targeted and compared as central distributors of the insulin signal, the insulin receptor, the insulin-like growth factor 1 receptor, and the insulin receptor-related receptor.
Title: The phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.
the insulin receptor tyrosine kinase family, comprising Ir, Igf1r and Irr, is required for the appearance of male gonads and thus for male sexual differentiation
Title: Testis determination requires insulin receptor family function in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Insrr (e-PCR), detects polymorphism
- UniSTS:525498

Insrr (e-PCR), detects polymorphism
- UniSTS:525248

AB007135 (e-PCR)
- UniSTS:163312

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor substrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to alkaline pH	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to alkaline pH	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male sex determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
part_of insulin receptor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: insulin receptor-related protein

Names: IR-related receptor

NP_035962.2

EC 2.7.10.1

XP_006501514.1

EC 2.7.10.1

XP_006501515.1

EC 2.7.10.1

XP_006501516.1

EC 2.7.10.1

XP_006501517.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011832.2 → NP_035962.2 insulin receptor-related protein precursor

See identical proteins and their annotated locations for NP_035962.2

Status: VALIDATED

Source sequence(s)

AB007135, AK142578

Consensus CDS

CCDS17454.1

UniProtKB/Swiss-Prot

B2RQC5, Q9WTL4

Related

ENSMUSP00000029711.3, ENSMUST00000029711.9

Conserved Domains (6) summary

cd05032
Location:972 → 1248

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:819 → 908

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:228 → 275

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:173 → 326

Furin-like; Furin-like cysteine rich region

pfam01030
Location:346 → 460

Recep_L_domain; Receptor L domain

pfam07714
Location:979 → 1246

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

87704215..87723408

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006501451.1 → XP_006501514.1 insulin receptor-related protein isoform X1

Conserved Domains (4) summary

cd05032
Location:972 → 1261

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:819 → 908

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:173 → 329

Furin-like; Furin-like cysteine rich region

pfam01030
Location:346 → 459

Recep_L_domain; Receptor L domain
XM_006501454.1 → XP_006501517.1 insulin receptor-related protein isoform X4

UniProtKB/TrEMBL

Q3UQC8

Conserved Domains (3) summary

cd00063
Location:819 → 861

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:173 → 329

Furin-like; Furin-like cysteine rich region

pfam01030
Location:346 → 459

Recep_L_domain; Receptor L domain
XM_006501453.1 → XP_006501516.1 insulin receptor-related protein isoform X3

UniProtKB/TrEMBL

Q3UQC8

Conserved Domains (3) summary

cd00063
Location:819 → 858

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:173 → 329

Furin-like; Furin-like cysteine rich region

pfam01030
Location:346 → 459

Recep_L_domain; Receptor L domain
XM_006501452.3 → XP_006501515.1 insulin receptor-related protein isoform X2

Conserved Domains (4) summary

cd05032
Location:853 → 1142

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:700 → 789

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:54 → 210

Furin-like; Furin-like cysteine rich region

pfam01030
Location:227 → 340

Recep_L_domain; Receptor L domain