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Rhof ras homolog family member F (in filopodia) [ Mus musculus (house mouse) ]

Gene ID: 23912, updated on 11-Apr-2024

Summary

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Official Symbol
Rhofprovided by MGI
Official Full Name
ras homolog family member F (in filopodia)provided by MGI
Primary source
MGI:MGI:1345629
See related
Ensembl:ENSMUSG00000029449 AllianceGenome:MGI:1345629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rif; Arhf; Ifld1
Summary
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; regulation of actin cytoskeleton organization; and regulation of cell shape. Predicted to be located in cytoplasm and membrane. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Orthologous to human RHOF (ras homolog family member F, filopodia associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 35.2), small intestine adult (RPKM 26.9) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Rhof in Genome Data Viewer
Location:
5 F; 5 62.77 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (123256243..123270692, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (123118180..123141808, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr5:123489053-123489354 Neighboring gene predicted gene, 42023 Neighboring gene MORN repeat containing 3 Neighboring gene STARR-seq mESC enhancer starr_14309 Neighboring gene STARR-positive B cell enhancer ABC_E6376 Neighboring gene predicted gene 6444 Neighboring gene transmembrane protein 120B Neighboring gene STARR-seq mESC enhancer starr_14311 Neighboring gene STARR-seq mESC enhancer starr_14312 Neighboring gene STARR-positive B cell enhancer ABC_E10349 Neighboring gene STARR-positive B cell enhancer ABC_E4788 Neighboring gene STARR-positive B cell enhancer ABC_E6377 Neighboring gene STARR-positive B cell enhancer ABC_E1060 Neighboring gene STARR-positive B cell enhancer ABC_E8079 Neighboring gene STARR-seq mESC enhancer starr_14314 Neighboring gene expressed sequence AI480526 Neighboring gene STARR-positive B cell enhancer ABC_E2763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123591600-123591709 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123599408-123599706 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:123599709-123599818 Neighboring gene STARR-positive B cell enhancer ABC_E6378 Neighboring gene SET domain containing 1B Neighboring gene predicted gene, 54284

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rhof promotes murine marginal zone B cell development. Kishimoto M, et al. Nagoya J Med Sci, 2014 Aug. PMID 25741038, Free PMC Article
  2. The small GTPase Rif is dispensable for platelet filopodia generation in mice. Goggs R, et al. PLoS One, 2013. PMID 23359340, Free PMC Article
  3. KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF. Shaverdashvili K, et al. PLoS One, 2019. PMID 30998758, Free PMC Article
  4. Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors. Goh WI, et al. J Biol Chem, 2011 Apr 15. PMID 21339294, Free PMC Article
  5. The Rho family GTPase Rif induces filopodia through mDia2. Pellegrin S, et al. Curr Biol, 2005 Jan 26. PMID 15668168

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RHOF is required for NFkappaB activation by KLF4 in esophageal keratinocytes and is also important for esophageal keratinocyte proliferation and migration.
    Title: KLF4 activates NFκB signaling and esophageal epithelial inflammation via the Rho-related GTP-binding protein RHOF.
  2. small GTPase Rif does not appear to be critical for platelet function in mice. Functional overlap between Rif and other small GTPases may be responsible for the non-essential role of Rif in platelets
    Title: The small GTPase Rif is dispensable for platelet filopodia generation in mice.
  3. Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors.
    Title: Rif-mDia1 interaction is involved in filopodium formation independent of Cdc42 and Rac effectors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rho-related GTP-binding protein RhoF
Names
induced in fatty liver dystrophy 1
ras homolog gene family, member f (in filopodia)
NP_780301.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175092.3 → NP_780301.1  rho-related GTP-binding protein RhoF

    See identical proteins and their annotated locations for NP_780301.1

    Status: VALIDATED

    Source sequence(s)
    AC158114, CK617811, DV646753
    Consensus CDS
    CCDS39263.1
    UniProtKB/Swiss-Prot
    Q8BYP3
    UniProtKB/TrEMBL
    Q4VA10
    Related
    ENSMUSP00000031401.6, ENSMUST00000031401.6
    Conserved Domains (1) summary
    cd04132
    Location:17 → 211
    Rho4_like; Ras homology family 4 (Rho4) of small guanosine triphosphatases (GTPases)-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    123256243..123270692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYP3.1 GenPept UniProtKB/Swiss-Prot:Q8BYP3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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