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Cdh24 cadherin-like 24 [ Mus musculus (house mouse) ]

Gene ID: 239096, updated on 11-Apr-2024

Summary

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Official Symbol
Cdh24provided by MGI
Official Full Name
cadherin-like 24provided by MGI
Primary source
MGI:MGI:1928330
See related
Ensembl:ENSMUSG00000059674 AllianceGenome:MGI:1928330
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1700040A22Rik
Summary
Predicted to enable several functions, including alpha-catenin binding activity; beta-catenin binding activity; and delta-catenin binding activity. Predicted to be involved in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell morphogenesis; and cell-cell junction organization. Predicted to act upstream of or within cell-cell adhesion. Predicted to be located in cell-cell junction. Predicted to be part of catenin complex. Predicted to be active in adherens junction. Is expressed in brain and retina. Orthologous to human CDH24 (cadherin 24). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 40.1), whole brain E14.5 (RPKM 18.9) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Cdh24 in Genome Data Viewer
Location:
14 C2; 14 27.87 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (54868688..54878853, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (54631231..54642067, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr14:55236824-55237125 Neighboring gene proteasome (prosome, macropain) subunit, beta type 5 Neighboring gene microRNA 686 Neighboring gene proteasome (prosome, macropain) subunit, beta type, 11 Neighboring gene microRNA 6948 Neighboring gene apoptotic chromatin condensation inducer 1 Neighboring gene RIKEN cDNA 4930579G18 gene Neighboring gene STARR-positive B cell enhancer ABC_E1473

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Multiple cadherin mRNA expression and developmental regulation of a novel cadherin in the developing mouse eye. Faulkner-Jones BE, et al. Exp Neurol, 1999 Apr. PMID 10328938
  2. Comparative analysis of type II classic cadherin mRNA distribution patterns in the developing and adult mouse somatosensory cortex and hippocampus suggests significant functional redundancy. Lefkovics K, et al. J Comp Neurol, 2012 May 1. PMID 22102170
  3. Differential Spatiotemporal Expression of Type I and Type II Cadherins Associated With the Segmentation of the Central Nervous System and Formation of Brain Nuclei in the Developing Mouse. Polanco J, et al. Front Mol Neurosci, 2021. PMID 33833667, Free PMC Article
  4. Type II cadherins guide assembly of a direction-selective retinal circuit. Duan X, et al. Cell, 2014 Aug 14. PMID 25126785
  5. A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. Bibollet-Bahena O, et al. PLoS One, 2017. PMID 28558017, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC67331

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables delta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cadherin-24
Names
EY-cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199470.3 → NP_955764.1  cadherin-24 precursor

    See identical proteins and their annotated locations for NP_955764.1

    Status: VALIDATED

    Source sequence(s)
    CT009512
    Consensus CDS
    CCDS36923.1
    UniProtKB/Swiss-Prot
    Q6PFX6
    Related
    ENSMUSP00000066005.7, ENSMUST00000067784.8
    Conserved Domains (4) summary
    cd11304
    Location:378 → 475
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:70 → 148
    CA; Cadherin repeats
    cl29226
    Location:485 → 577
    Cadherin; Cadherin domain
    pfam01049
    Location:625 → 776
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    54868688..54878853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247794.2 → XP_030103654.1  cadherin-24 isoform X2

    Conserved Domains (2) summary
    cd11304
    Location:154 → 255
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:70 → 148
    CA; Cadherin repeats

  2. XM_006518975.5 → XP_006519038.1  cadherin-24 isoform X3

    Conserved Domains (2) summary
    cd11304
    Location:154 → 255
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:70 → 148
    CA; Cadherin repeats
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFX6.1 GenPept UniProtKB/Swiss-Prot:Q6PFX6

Gene LinkOut

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