Tlr11 toll-like receptor 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlr11provided by MGI
Official Full Name: toll-like receptor 11provided by MGI
Primary source: MGI:MGI:3045226
See related: Ensembl:ENSMUSG00000051969 AllianceGenome:MGI:3045226
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm287
Summary: Predicted to enable signaling receptor activity. Acts upstream of or within response to bacterium. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 1.4), mammary gland adult (RPKM 1.0) and 11 other tissues See more
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Genomic context

Location:: 14 C1; 14 26.07 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (50595371..50601120)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (50357914..50363663)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study demonstrates the important role of GRA15 and GRA24 in activating the innate immune response in hosts lacking TLR11.
Title: Toxoplasma GRA15 and GRA24 are important activators of the host innate immune response in the absence of TLR11.
TLR11 or TLR12 silencing reduces parasite burden and increases IFN-gamma, but reduces IL-4, production indicating that TLR11 and TLR12 play a pro-leishmanial role.
Title: TLR11 or TLR12 silencing reduces Leishmania major infection.
mechanisms of interaction with flagellin and profilin
Title: Toll-Like Receptor 11 (TLR11) Interacts with Flagellin and Profilin through Disparate Mechanisms.
Data show that TLR11 expression is induced in astrocytes, neurons, and microglia in the immune response to T. gondii infection
Title: Astrocytes, microglia/macrophages, and neurons expressing Toll-like receptor 11 contribute to innate immunity against encephalitic Toxoplasma gondii infection.
TLR11 mediates innate immune function of male germ cells in response to T. gondii profilin and uropathogenic escherichia coli stimulations.
Title: Toll-like receptor 11-initiated innate immune response in male mouse germ cells.
Biochemical experiments revealed that TLR11 and TLR12 directly bind to Toxoplasma gondii profilin and are capable of forming a heterodimer complex.
Title: Cooperation of TLR12 and TLR11 in the IRF8-dependent IL-12 response to Toxoplasma gondii profilin.
Selective elimination of neutrophils in TLR11-deficient mice infected with Toxoplasma gondii results in acute susceptibility similar to that observed in IFN-gamma-deficient mice.
Title: TLR-independent neutrophil-derived IFN-γ is important for host resistance to intracellular pathogens.
While parasite RNA and DNA activate innate immune responses via TLR7 and TLR9, TLR11 and TLR12 heterodimers are required for sensing and responding to Toxoplasma profilin infection.
Title: Combined action of nucleic acid-sensing Toll-like receptors and TLR11/TLR12 heterodimers imparts resistance to Toxoplasma gondii in mice.
a potentially important role for TLR11 in preventing murine intestinal infection and modulating antigen transportation in the gut and imply an important role for various TLRs in cooperation with tight control of pathogens penetrating into Peyer patches.
Title: Toll-like receptor 11 (TLR11) prevents Salmonella penetration into the murine Peyer patches.
association with UNC93B1 and the intracellular localization of TLRs are not unique features of nucleic acid-sensing TLRs but is also essential for TLR11-dependent recognition of T. gondii profilin and for host protection against this parasite
Title: UNC93B1 is essential for TLR11 activation and IL-12-dependent host resistance to Toxoplasma gondii.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	IMP Inferred from Mutant Phenotype more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: toll-like receptor 11

Names: toll-like receptor 12

NP_991388.2

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205819.3 → NP_991388.2 toll-like receptor 11

Status: VALIDATED

Source sequence(s)

AC135188, AI646605, AY510704

Consensus CDS

CCDS27012.2

UniProtKB/Swiss-Prot

Q6R5P0

UniProtKB/TrEMBL

V9GWT0

Related

ENSMUSP00000138814.2, ENSMUST00000185091.2

Conserved Domains (4) summary

cd00116
Location:184 → 427

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:224 → 246

LRR_RI; leucine-rich repeat [structural motif]

pfam13676
Location:781 → 861

TIR_2; TIR domain

pfam13855
Location:366 → 426

LRR_8; Leucine rich repeat