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Arhgap22 Rho GTPase activating protein 22 [ Mus musculus (house mouse) ]

Gene ID: 239027, updated on 11-Apr-2024

Summary

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Official Symbol
Arhgap22provided by MGI
Official Full Name
Rho GTPase activating protein 22provided by MGI
Primary source
MGI:MGI:2443418
See related
Ensembl:ENSMUSG00000063506 AllianceGenome:MGI:2443418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RHOGAP2; p68RacGAP; B230341L19Rik
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and regulation of postsynapse organization. Predicted to act upstream of or within angiogenesis and cell differentiation. Predicted to be located in cytoplasm and nucleus. Predicted to be active in glutamatergic synapse. Orthologous to human ARHGAP22 (Rho GTPase activating protein 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 3.9), ovary adult (RPKM 3.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Arhgap22 in Genome Data Viewer
Location:
14 B; 14 20.15 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (32935952..33091893)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33213994..33369936)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36348 Neighboring gene predicted gene, 25498 Neighboring gene predicted pseudogene 6340 Neighboring gene predicted gene, 41130 Neighboring gene STARR-seq mESC enhancer starr_36351 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene STARR-seq mESC enhancer starr_36353 Neighboring gene FERM and PDZ domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation. Aitsebaomo J, et al. J Biol Chem, 2004 Apr 23. PMID 14966113
  2. Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice. Longatti A, et al. Mol Neurobiol, 2021 Dec. PMID 34455539, Free PMC Article
  3. OTX2 Transcription Factor Controls Regional Patterning within the Medial Ganglionic Eminence and Regional Identity of the Septum. Hoch RV, et al. Cell Rep, 2015 Jul 21. PMID 26166575, Free PMC Article
  4. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Pilot-Storck F, et al. Mol Cell Proteomics, 2010 Jul. PMID 20368287, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice.
    Title: Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice.
  2. a multifunctional regulatory protein with Rac1-specific GTPase-activating activity; regulates transcriptional activity of the endothelin-1 promoter; involved in the signal transduction pathway regulating endothelial cell capillary tube formation
    Title: p68RacGAP is a novel GTPase-activating protein that interacts with vascular endothelial zinc finger-1 and modulates endothelial cell capillary formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC47316

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho GTPase-activating protein 22
Names
rho-type GTPase-activating protein 22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153800.4 → NP_722495.3  rho GTPase-activating protein 22

    See identical proteins and their annotated locations for NP_722495.3

    Status: VALIDATED

    Source sequence(s)
    AK046097, AK078218, BB370610
    Consensus CDS
    CCDS26926.2
    UniProtKB/Swiss-Prot
    Q6QHH6, Q8BL80, Q8BVH4, Q8CHY5
    Related
    ENSMUSP00000107587.3, ENSMUST00000111956.9
    Conserved Domains (4) summary
    cd04390
    Location:157 → 355
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:602 → 683
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:493 → 683
    Macoilin; Macoilin family
    cl17171
    Location:42 → 157
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    32935952..33091893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518956.5 → XP_006519019.1  rho GTPase-activating protein 22 isoform X3

    Conserved Domains (3) summary
    cd04390
    Location:173 → 371
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    TIGR02168
    Location:610 → 698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:42 → 157
    PH-like; Pleckstrin homology-like domain

  2. XM_011245053.4 → XP_011243355.1  rho GTPase-activating protein 22 isoform X5

    See identical proteins and their annotated locations for XP_011243355.1

    UniProtKB/Swiss-Prot
    Q6QHH6, Q8BL80, Q8BVH4, Q8CHY5
    Conserved Domains (4) summary
    cd04390
    Location:157 → 355
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:602 → 683
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:493 → 683
    Macoilin; Macoilin family
    cl17171
    Location:42 → 157
    PH-like; Pleckstrin homology-like domain

  3. XM_036158588.1 → XP_036014481.1  rho GTPase-activating protein 22 isoform X3

    Conserved Domains (3) summary
    cd04390
    Location:173 → 371
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    TIGR02168
    Location:610 → 698
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl17171
    Location:42 → 157
    PH-like; Pleckstrin homology-like domain

  4. XM_006518957.5 → XP_006519020.1  rho GTPase-activating protein 22 isoform X4

    Conserved Domains (4) summary
    cd04390
    Location:167 → 365
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:612 → 693
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:503 → 693
    Macoilin; Macoilin family
    cl17171
    Location:36 → 151
    PH-like; Pleckstrin homology-like domain

  5. XM_030247787.2 → XP_030103647.1  rho GTPase-activating protein 22 isoform X6

    Conserved Domains (4) summary
    cd04390
    Location:151 → 349
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:596 → 677
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:487 → 677
    Macoilin; Macoilin family
    cl17171
    Location:36 → 151
    PH-like; Pleckstrin homology-like domain

  6. XM_006518954.5 → XP_006519017.1  rho GTPase-activating protein 22 isoform X1

    Conserved Domains (4) summary
    cd04390
    Location:193 → 391
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:638 → 719
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:529 → 719
    Macoilin; Macoilin family
    cl17171
    Location:62 → 177
    PH-like; Pleckstrin homology-like domain

  7. XM_017316004.3 → XP_017171493.1  rho GTPase-activating protein 22 isoform X2

    Conserved Domains (4) summary
    cd04390
    Location:177 → 375
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:622 → 703
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:513 → 703
    Macoilin; Macoilin family
    cl17171
    Location:62 → 177
    PH-like; Pleckstrin homology-like domain

  8. XM_017316006.3 → XP_017171495.1  rho GTPase-activating protein 22 isoform X7

    Conserved Domains (4) summary
    cd04390
    Location:134 → 332
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:579 → 660
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:470 → 660
    Macoilin; Macoilin family
    cl17171
    Location:62 → 147
    PH-like; Pleckstrin homology-like domain

  9. XM_006518959.3 → XP_006519022.1  rho GTPase-activating protein 22 isoform X8

    UniProtKB/TrEMBL
    D3Z1Y5
    Conserved Domains (4) summary
    cd04390
    Location:77 → 275
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:522 → 603
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:413 → 603
    Macoilin; Macoilin family
    cl17171
    Location:18 → 61
    PH-like; Pleckstrin homology-like domain

  10. XM_006518961.5 → XP_006519024.1  rho GTPase-activating protein 22 isoform X10

    UniProtKB/TrEMBL
    D3Z1Y5
    Related
    ENSMUSP00000107586.2, ENSMUST00000111955.2
    Conserved Domains (4) summary
    cd04390
    Location:61 → 259
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:506 → 587
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:397 → 587
    Macoilin; Macoilin family
    cl17171
    Location:18 → 61
    PH-like; Pleckstrin homology-like domain

  11. XM_036158589.1 → XP_036014482.1  rho GTPase-activating protein 22 isoform X13

    UniProtKB/TrEMBL
    D3Z1Y5
    Conserved Domains (2) summary
    cd04390
    Location:18 → 216
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    TIGR02168
    Location:455 → 543
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  12. XM_006518960.4 → XP_006519023.1  rho GTPase-activating protein 22 isoform X9

    UniProtKB/TrEMBL
    D3Z1Y5
    Conserved Domains (4) summary
    cd04390
    Location:77 → 275
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:522 → 603
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:413 → 603
    Macoilin; Macoilin family
    cl17171
    Location:18 → 61
    PH-like; Pleckstrin homology-like domain

  13. XM_006518962.4 → XP_006519025.1  rho GTPase-activating protein 22 isoform X11

    UniProtKB/TrEMBL
    D3Z1Y5
    Related
    ENSMUST00000137590.8
    Conserved Domains (4) summary
    cd04390
    Location:61 → 259
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:506 → 587
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:397 → 587
    Macoilin; Macoilin family
    cl17171
    Location:18 → 61
    PH-like; Pleckstrin homology-like domain

  14. XM_006518963.5 → XP_006519026.1  rho GTPase-activating protein 22 isoform X12

    UniProtKB/TrEMBL
    D3Z1Y5
    Conserved Domains (3) summary
    cd04390
    Location:33 → 231
    RhoGAP_ARHGAP22_24_25; GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for ...
    pfam07111
    Location:478 → 559
    HCR; Alpha helical coiled-coil rod protein (HCR)
    pfam09726
    Location:369 → 559
    Macoilin; Macoilin family

  15. XM_011245054.1 → XP_011243356.1  rho GTPase-activating protein 22 isoform X14

    Conserved Domains (3) summary
    TIGR02168
    Location:286 → 374
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam09726
    Location:185 → 375
    Macoilin; Macoilin family
    cl02570
    Location:1 → 47
    RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...

RNA

  1. XR_004938394.1 RNA Sequence

  2. XR_003950847.2 RNA Sequence

  3. XR_004938393.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BL80.2 GenPept UniProtKB/Swiss-Prot:Q8BL80

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