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Ogdhl oxoglutarate dehydrogenase-like [ Mus musculus (house mouse) ]

Gene ID: 239017, updated on 11-Apr-2024

Summary

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Official Symbol
Ogdhlprovided by MGI
Official Full Name
oxoglutarate dehydrogenase-likeprovided by MGI
Primary source
MGI:MGI:3616088
See related
Ensembl:ENSMUSG00000021913 AllianceGenome:MGI:3616088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable oxoglutarate dehydrogenase (succinyl-transferring) activity. Predicted to be involved in 2-oxoglutarate metabolic process and tricarboxylic acid cycle. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Predicted to be active in mitochondrion. Orthologous to human OGDHL (oxoglutarate dehydrogenase L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 30.8), cerebellum adult (RPKM 18.6) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 B; 14 19.4 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (32043941..32070108)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (32321982..32348151)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene poly (ADP-ribose) glycohydrolase Neighboring gene tetratricopeptide repeat domain 35 pseudogene Neighboring gene STARR-seq mESC enhancer starr_36341 Neighboring gene predicted gene, 48914 Neighboring gene predicted gene, 52134 Neighboring gene RIKEN cDNA 1700024G13 gene Neighboring gene STARR-seq mESC enhancer starr_36344 Neighboring gene choline acetyltransferase Neighboring gene solute carrier family 18 (vesicular monoamine), member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Osteopontin Promotes Left Ventricular Diastolic Dysfunction Through a Mitochondrial Pathway. Yousefi K, et al. J Am Coll Cardiol, 2019 Jun 4. PMID 31146816, Free PMC Article
  2. The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development. Xu M, et al. Development, 2021 Apr 15. PMID 33913477
  3. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
  4. Characterization of the Cardiac Overexpression of HSPB2 Reveals Mitochondrial and Myogenic Roles Supported by a Cardiac HspB2 Interactome. Grose JH, et al. PLoS One, 2015. PMID 26465331, Free PMC Article
  5. Interactome Analysis Reveals Regulator of G Protein Signaling 14 (RGS14) is a Novel Calcium/Calmodulin (Ca(2+)/CaM) and CaM Kinase II (CaMKII) Binding Partner. Evans PR, et al. J Proteome Res, 2018 Apr 6. PMID 29518331, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables oxoglutarate dehydrogenase (succinyl-transferring) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in 2-oxoglutarate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tricarboxylic acid cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tricarboxylic acid cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oxoglutarate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
2-oxoglutarate dehydrogenase-like, mitochondrial
NP_001074599.2
XP_030103646.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081130.2 → NP_001074599.2  2-oxoglutarate dehydrogenase-like, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    AC167565, BC157970
    Consensus CDS
    CCDS36866.2
    UniProtKB/TrEMBL
    B2RXT3, E9Q7L0
    Related
    ENSMUSP00000154185.2, ENSMUST00000228529.2
    Conserved Domains (1) summary
    PRK09404
    Location:45 → 1001
    sucA; 2-oxoglutarate dehydrogenase E1 component; Reviewed

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    32043941..32070108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247786.2 → XP_030103646.1  2-oxoglutarate dehydrogenase-like, mitochondrial isoform X1

    Conserved Domains (1) summary
    cl39092
    Location:45 → 714
    SucA; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version

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