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Gtf2h2 general transcription factor II H, polypeptide 2 [ Mus musculus (house mouse) ]

Gene ID: 23894, updated on 11-Apr-2024

Summary

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Official Symbol
Gtf2h2provided by MGI
Official Full Name
general transcription factor II H, polypeptide 2provided by MGI
Primary source
MGI:MGI:1345669
See related
Ensembl:ENSMUSG00000021639 AllianceGenome:MGI:1345669
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p44; 44kDa; Btf2p44; BTF2 p44; BTF2-p44
Summary
Predicted to enable RNA polymerase II general transcription initiation factor activity and protein N-terminus binding activity. Predicted to be involved in nucleotide-excision repair and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within DNA repair. Predicted to be located in nuclear speck. Predicted to be part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and nervous system. Orthologous to several human genes including GTF2H2C (GTF2H2 family member C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.7), limb E14.5 (RPKM 9.8) and 28 other tissues See more
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Genomic context

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See Gtf2h2 in Genome Data Viewer
Location:
13 D1; 13 53.21 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100596726..100629123, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100460218..100492609, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 38 pseudogene Neighboring gene ribosomal protein L31, pseudogene 13 Neighboring gene NLR family, apoptosis inhibitory protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1467 Neighboring gene occludin Neighboring gene predicted gene, 57598 Neighboring gene eukaryotic translation initiation factor 4, gamma 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structural characterization of the cysteine-rich domain of TFIIH p44 subunit. Fribourg S, et al. J Biol Chem, 2000 Oct 13. PMID 10882739
  2. TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus. Le May N, et al. Cell, 2004 Feb 20. PMID 14980221
  3. Human and mouse RAD17 genes: identification, localization, genomic structure and histological expression pattern in normal testis and seminoma. von Deimling F, et al. Hum Genet, 1999 Jul-Aug. PMID 10480350
  4. Genomic sequence analysis of the mouse Naip gene array. Endrizzi MG, et al. Genome Res, 2000 Aug. PMID 10958627, Free PMC Article
  5. Evolutionary divergence of the mouse and human Lgn1/SMA repeat structures. Growney JD, et al. Genomics, 2000 Feb 15. PMID 10708519

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleotide-excision repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of core TFIIH complex portion of holo TFIIH complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH core complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIIH holo complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIH holo complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
general transcription factor IIH subunit 2
Names
TFIIH basal transcription factor complex p44 subunit
basal transcription factor 2, p44 subunit
basic transcription factor 2 44 kDa subunit
general transcription factor II H, polypeptide 2 (44 kDa subunit)
general transcription factor IIH, polypeptide 2 (44 kDa subunit)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360706.1 → NP_001347635.1  general transcription factor IIH subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158536
    UniProtKB/TrEMBL
    Q7TPV0
    Conserved Domains (2) summary
    cl06838
    Location:289 → 389
    C1_4; TFIIH C1-like domain
    pfam04056
    Location:64 → 255
    Ssl1; Ssl1-like

  2. NM_022011.4 → NP_071294.3  general transcription factor IIH subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_071294.3

    Status: VALIDATED

    Source sequence(s)
    BC053382, BY277671, BY480509, DV662169
    Consensus CDS
    CCDS26730.1
    UniProtKB/Swiss-Prot
    Q9JIB4
    UniProtKB/TrEMBL
    Q7TPV0
    Related
    ENSMUSP00000065228.8, ENSMUST00000066984.14
    Conserved Domains (2) summary
    pfam04056
    Location:64 → 255
    Ssl1; Ssl1-like
    cl06838
    Location:289 → 389
    C1_4; TFIIH C1-like domain

RNA

  1. NR_153794.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158536
    Related
    ENSMUST00000145266.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100596726..100629123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517662.3 → XP_006517725.1  general transcription factor IIH subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_006517725.1

    UniProtKB/TrEMBL
    Q7TPV0
    Conserved Domains (2) summary
    cl06838
    Location:289 → 389
    C1_4; TFIIH C1-like domain
    pfam04056
    Location:64 → 255
    Ssl1; Ssl1-like

RNA

  1. XR_873756.4 RNA Sequence

  2. XR_873759.4 RNA Sequence

  3. XR_004938028.1 RNA Sequence

  4. XR_004938029.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JIB4.1 GenPept UniProtKB/Swiss-Prot:Q9JIB4

Gene LinkOut

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