Pde4d phosphodiesterase 4D, cAMP specific [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pde4dprovided by MGI
Official Full Name: phosphodiesterase 4D, cAMP specificprovided by MGI
Primary source: MGI:MGI:99555
See related: Ensembl:ENSMUSG00000021699 AllianceGenome:MGI:99555
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dpde3; 9630011N22Rik
Summary: Enables 3',5'-cyclic-AMP phosphodiesterase activity; ATPase binding activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of heart contraction; and regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; neutrophil chemotaxis; and smooth muscle contraction. Located in centrosome. Part of potassium channel complex and voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acrodysostosis. Orthologous to human PDE4D (phosphodiesterase 4D). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 2.7), thymus adult (RPKM 2.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.1; 13 59.69 cM

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (108790711..110092503)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (108654177..109955969)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PDE4D mediates impaired beta-adrenergic receptor signalling in the sinoatrial node in mice with hypertensive heart disease.
Title: PDE4D mediates impaired β-adrenergic receptor signalling in the sinoatrial node in mice with hypertensive heart disease.
Genetic deletion of phosphodiesterase 4D in the liver improves kidney damage in high-fat fed mice: liver-kidney crosstalk.
Title: Genetic deletion of phosphodiesterase 4D in the liver improves kidney damage in high-fat fed mice: liver-kidney crosstalk.
Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory.
Title: Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory.
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-beta pathology.
Title: Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology.
Circ_0101874 overexpression strengthens PDE4D expression by targeting miR-335-5p to promote neuronal injury in ischemic stroke.
Title: Circ_0101874 overexpression strengthens PDE4D expression by targeting miR-335-5p to promote neuronal injury in ischemic stroke.
Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis.
Title: Phosphodiesterase 4D contributes to angiotensin II-induced abdominal aortic aneurysm through smooth muscle cell apoptosis.
Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior.
Title: Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior.
Upregulation of miR-219a-5p Decreases Cerebral Ischemia/Reperfusion Injury In Vitro by Targeting Pde4d.
Title: Upregulation of miR-219a-5p Decreases Cerebral Ischemia/Reperfusion Injury In Vitro by Targeting Pde4d.
Proteomics identified the PP2A regulatory subunit B55alpha as the factor recruiting PP2A to PDE4D5. The B55alpha-PP2A complex localized to adhesions and directly dephosphorylated PDE4D5.
Title: Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis.
Long-term memory is enhanced by retrosplenial and hippocampal knockdown (KD) of the cAMP specific phosphodiesterase Pde4d.
Title: PDE4D regulates Spine Plasticity and Memory in the Retrosplenial Cortex.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:224785

D13Mit148 (e-PCR), detects polymorphism
- UniSTS:116556

AI481207 (e-PCR)
- UniSTS:160344

AI452195 (e-PCR)
- UniSTS:160345

BB520687 (e-PCR)
- UniSTS:208991

D13Mill1 (e-PCR), detects polymorphism
- UniSTS:141930

D13Mill2 (e-PCR), detects polymorphism
- UniSTS:141931

RH124824 (e-PCR)
- UniSTS:161646

D13Mit289 (e-PCR), detects polymorphism
- UniSTS:127108

D13Mit317 (e-PCR), detects polymorphism
- UniSTS:127136

T25635 (e-PCR)
- UniSTS:125632

13.MMHAP86FRE7.seq (e-PCR)
- UniSTS:186310

PMC56953P1 (e-PCR)
- UniSTS:273361

Pde4d (e-PCR), detects polymorphism
- UniSTS:507124

AW532750 (e-PCR)
- UniSTS:260604

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables 3',5'-cyclic-AMP phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables 3',5'-cyclic-GMP phosphodiesterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3',5'-cyclic-nucleotide phosphodiesterase activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables beta-2 adrenergic receptor binding	ISO Inferred from Sequence Orthology more info
enables cAMP binding	ISO Inferred from Sequence Orthology more info
enables calcium channel regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cyclic-nucleotide phosphodiesterase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heterocyclic compound binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor regulator activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cAMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cAMP-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in cAMP-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cellular response to epinephrine stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to epinephrine stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of relaxation of cardiac muscle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ovulation from ovarian follicle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of cAMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle cell contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell communication by electrical coupling involved in cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smooth muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in myofibril	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of potassium channel complex	IPI Inferred from Physical Interaction more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 3',5'-cyclic-AMP phosphodiesterase 4D

Names: cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cyclic AMP specific phosphodiesterase PDE4D5A; dunce

NP_001389812.1

EC 3.1.4.53

NP_001389813.1

EC 3.1.4.53

NP_001389814.1

EC 3.1.4.53

NP_001389815.1

EC 3.1.4.53

NP_001389816.1

EC 3.1.4.53

NP_001389817.1

EC 3.1.4.53

NP_035186.1

EC 3.1.4.53

XP_030103122.1

EC 3.1.4.53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001402883.1 → NP_001389812.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 2

Status: VALIDATED

Source sequence(s)

AC102805, AC161585, AC163650

UniProtKB/TrEMBL

E9PVU7

Related

ENSMUSP00000112991.2, ENSMUST00000120671.8
NM_001402884.1 → NP_001389813.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 3

Status: VALIDATED

Source sequence(s)

AC154756, AC161585, AC163650

Related

ENSMUSP00000121592.2, ENSMUST00000153234.8
NM_001402885.1 → NP_001389814.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 4

Status: VALIDATED

Source sequence(s)

AC161585, AC163650, CT033775

UniProtKB/TrEMBL

B2KF84

Related

ENSMUSP00000114089.2, ENSMUST00000119507.8
NM_001402886.1 → NP_001389815.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 5

Status: VALIDATED

Source sequence(s)

AC161585, AC163650

Related

ENSMUSP00000073742.6, ENSMUST00000074103.12
NM_001402887.1 → NP_001389816.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 6

Status: VALIDATED

Source sequence(s)

AC163650

UniProtKB/TrEMBL

A6XDA7

Related

ENSMUSP00000113024.2, ENSMUST00000120664.8
NM_001402888.1 → NP_001389817.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 7

Status: VALIDATED

Source sequence(s)

AC163650

UniProtKB/TrEMBL

A6XDB0

Related

ENSMUSP00000113610.2, ENSMUST00000117420.8
NM_011056.3 → NP_035186.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform 1

See identical proteins and their annotated locations for NP_035186.1

Status: VALIDATED

Source sequence(s)

AC156571, AC161585, AC163650, AC174458, CT025614

Consensus CDS

CCDS49359.1

UniProtKB/Swiss-Prot

B2KF58, Q01063, Q6TRH9, Q8C4Q7, Q8CG05

UniProtKB/TrEMBL

A2RSH1, B1PSD9

Related

ENSMUSP00000113488.2, ENSMUST00000122041.8

Conserved Domains (1) summary

pfam00233
Location:400 → 641

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

108790711..110092503

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247262.2 → XP_030103122.1 3',5'-cyclic-AMP phosphodiesterase 4D isoform X4

UniProtKB/TrEMBL

B2KF57

Related

ENSMUSP00000119583.2, ENSMUST00000135275.8

Conserved Domains (2) summary

pfam00233
Location:339 → 580

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

pfam18100
Location:101 → 217

PDE4_UCR; Phosphodiesterase 4 upstream conserved regions (UCR)